3mod - Revision history

OCA at 08:57, 6 September 2023

2023-09-06T08:57:58Z

← Older revision		Revision as of 08:57, 6 September 2023
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	<StructureSection load='3mod' size='340' side='right'caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mod' size='340' side='right'caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MOD FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [https://pdbe.org/3mod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [https://www.ebi.ac.uk/pdbsum/3mod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [https://pdbe.org/3mod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [https://www.ebi.ac.uk/pdbsum/3mod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/ENV_HV1Z6 ENV_HV1Z6] The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide. Surface protein gp120 (SU) may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS (By similarity). The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they take up antigen, process it, and present it to T-cells following migration to lymphoid organs. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells. Virion capture also seems to lead to MHC-II-restricted viral antigen presentation, and probably to the activation of HIV-specific CD4+ cells (By similarity). The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity). The gp120-gp41 heterodimer seems to contribute to T-cell depletion during HIV-1 infection. The envelope glycoproteins expressed on the surface of infected cells induce apoptosis through an interaction with uninfected cells expressing the receptor (CD4) and the coreceptors CXCR4 or CCR5. This type of bystander killing may be obtained by at least three distinct mechanisms. First, the interaction between the 2 cells can induce cellular fusion followed by nuclear fusion within the syncytium. Syncytia are condemned to die from apoptosis. Second, the 2 interacting cells may not fuse entirely and simply exchange plasma membrane lipids, after a sort of hemifusion process, followed by rapid death. Third, it is possible that virus-infected cells, on the point of undergoing apoptosis, fuse with CD4-expressing cells, in which case apoptosis is rapidly transmitted from one cell to the other and thus occurs in a sort of contagious fashion (By similarity). The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Homo sapiens]]
			[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alam~~, S M~~]]		[[Category: Alam SM]]
	[[Category: Dennison~~, S M~~]]		[[Category: Dennison SM]]
	[[Category: Haynes~~, B F~~]]		[[Category: Haynes BF]]
	[[Category: Kelsoe, G]]		[[Category: Kelsoe G]]
	[[Category: Liao, H X]]		[[Category: Liao H-X]]
	[[Category: Nicely~~, N I]]~~		[[Category: Nicely NI]]
	~~[[Category: Fab antibody]]~~
	~~[[Category: Hiv gp41 mper]]~~
	~~[[Category: Hiv-1]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Z13~~]]

OCA at 18:31, 27 July 2022

2022-07-27T18:31:33Z

← Older revision		Revision as of 18:31, 27 July 2022
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	<StructureSection load='3mod' size='340' side='right'caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mod' size='340' side='right'caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3MOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MOD FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [~~http~~://pdbe.org/3mod PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mod PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [https://pdbe.org/3mod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [https://www.ebi.ac.uk/pdbsum/3mod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:58, 21 October 2020

2020-10-21T08:58:46Z

← Older revision		Revision as of 08:58, 21 October 2020
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	==Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide==		==Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide==
	<StructureSection load='3mod' size='340' side='right' caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mod' size='340' side='right'caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MOD FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [http://pdbe.org/3mod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [http://www.ebi.ac.uk/pdbsum/3mod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [http://pdbe.org/3mod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [http://www.ebi.ac.uk/pdbsum/3mod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>
	</table>		</table>

	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[3D structures of human antibody\|3D structures of human antibody]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Alam, S M]]		[[Category: Alam, S M]]
	[[Category: Dennison, S M]]		[[Category: Dennison, S M]]

OCA at 13:11, 16 January 2019

2019-01-16T13:11:14Z

← Older revision		Revision as of 13:11, 16 January 2019
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	==See Also==		==See Also==
	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:02, 4 August 2016

2016-08-04T10:02:39Z

← Older revision		Revision as of 10:02, 4 August 2016
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	==Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide==		==Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide==
	<StructureSection load='3mod' size='340' side='right' caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mod' size='340' side='right' caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [http://www.ebi.ac.uk/pdbsum/3mod PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [http://pdbe.org/3mod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [http://www.ebi.ac.uk/pdbsum/3mod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mod ProSAT]</span></td></tr>
	</table>		</table>

	==See Also==		==See Also==
	*[[~~Antibody~~\|~~Antibody~~]]		*[[3D structures of antibody\|3D structures of antibody]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:41, 21 December 2014

2014-12-21T16:41:56Z

← Older revision		Revision as of 16:41, 21 December 2014
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	~~{{STRUCTURE_3mod\| PDB=3mod \| SCENE= }}~~		==Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide==
	===Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide===		<StructureSection load='3mod' size='340' side='right' caption='[[3mod]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
	==~~About this Structure~~==		<table><tr><td colspan='2'>[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MOD FirstGlance]. <br>
	[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] ~~and~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Human Human~~]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~3MOD~~ OCA].		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mnv\|3mnv]], [[3mnw\|3mnw]], [[3mnz\|3mnz]], [[3mo1\|3mo1]], [[3moa\|3moa]], [[3mob\|3mob]], [[1tjh\|1tjh]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mod RCSB], [http://www.ebi.ac.uk/pdbsum/3mod PDBsum]</span></td></tr>
			</table>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
			__TOC__
			</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Alam, S M.]]		[[Category: Alam, S M]]
	[[Category: Dennison, S M.]]		[[Category: Dennison, S M]]
	[[Category: Haynes, B F.]]		[[Category: Haynes, B F]]
	[[Category: Kelsoe, G.]]		[[Category: Kelsoe, G]]
	[[Category: Liao, H X.]]		[[Category: Liao, H X]]
	[[Category: Nicely, N I~~.]]~~		[[Category: Nicely, N I]]
	~~[[Category: 13h11]]~~
	~~[[Category: 2f5]]~~
	~~[[Category: 4e10~~]]
	[[Category: Fab antibody]]		[[Category: Fab antibody]]
	[[Category: Hiv gp41 mper]]		[[Category: Hiv gp41 mper]]

OCA at 08:55, 5 February 2014

2014-02-05T08:55:10Z

← Older revision		Revision as of 08:55, 5 February 2014
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	==About this Structure==		==About this Structure==
	[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA].		[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA].

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Alam, S M.]]		[[Category: Alam, S M.]]
	[[Category: Dennison, S M.]]		[[Category: Dennison, S M.]]

OCA: Protected "3mod" [edit=sysop:move=sysop]

2013-04-17T21:04:28Z

Protected "3mod" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:04, 17 April 2013
(No difference)

OCA at 21:04, 17 April 2013

2013-04-17T21:04:25Z

← Older revision		Revision as of 21:04, 17 April 2013
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	~~{{Seed}}~~
	~~[[Image:3mod.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3mod", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3mod\| PDB=3mod \| SCENE= }}		{{STRUCTURE_3mod\| PDB=3mod \| SCENE= }}

	===Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide===		===Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide===

			==About this Structure==
			[[3mod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA].

	==~~About this Structure~~==		==See Also==
	~~3MOD is a 3 chains structure with sequences from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOD OCA~~].		*[[Antibody\|Antibody]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Alam, S M.]]		[[Category: Alam, S M.]]
Line 30:		Line 22:
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Z13]]		[[Category: Z13]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:50:21 2010''~~

OCA at 21:39, 17 November 2010

2010-11-17T21:39:07Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3mod is ON HOLD
+<!--
-Authors: Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F.
+===Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:27:48 2010''
+==About this Structure==