3mud - Revision history

OCA at 09:01, 6 September 2023

2023-09-06T09:01:36Z

← Older revision		Revision as of 09:01, 6 September 2023
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	<StructureSection load='3mud' size='340' side='right'caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mud' size='340' side='right'caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MUD FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3mtu\|3mtu]]~~, ~~[[2g9j\|2g9j]]~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [~~http~~://pdbe.org/3mud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [https://pdbe.org/3mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [https://www.ebi.ac.uk/pdbsum/3mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mud ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[[http://www.uniprot.org/uniprot/TPM1_HUMAN TPM1_HUMAN]] Left ventricular noncompaction;Familial isolated hypertrophic cardiomyopathy;Familial isolated dilated cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> [[~~http~~://www.uniprot.org/uniprot/~~TPM1_HUMAN TPM1_HUMAN]~~] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.		[https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> [https://www.uniprot.org/uniprot/TPM1_CHICK TPM1_CHICK] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Gallus gallus]]
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Frye, J]]		[[Category: Frye J]]
	[[Category: Klenchin~~, V A~~]]		[[Category: Klenchin VA]]
	[[Category: Rayment, I]]		[[Category: Rayment I]]
	~~[[Category: Coiled-coil]]~~
	~~[[Category: Contractile protein]]~~
	~~[[Category: Overlap complex]]~~
	~~[[Category: Tropomysoin~~]]

OCA at 16:39, 28 August 2019

2019-08-28T16:39:00Z

← Older revision		Revision as of 16:39, 28 August 2019
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	==Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle==		==Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle==
	<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mud' size='340' side='right'caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/3mud_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/3mud_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Frye, J]]		[[Category: Frye, J]]
	[[Category: Klenchin, V A]]		[[Category: Klenchin, V A]]

OCA at 11:08, 3 August 2017

2017-08-03T11:08:03Z

← Older revision		Revision as of 11:08, 3 August 2017
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	<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mtu\|3mtu]], [[2g9j\|2g9j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mtu\|3mtu]], [[2g9j\|2g9j]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">XRCC4, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAPRE1, RCJMB04_6l6, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://pdbe.org/3mud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://pdbe.org/3mud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mud ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/TPM1_HUMAN TPM1_HUMAN]] Left ventricular noncompaction;Familial isolated hypertrophic cardiomyopathy;Familial isolated dilated cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> [[http://www.uniprot.org/uniprot/~~TPM1_CHICK TPM1_CHICK~~]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.		[[http://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> [[http://www.uniprot.org/uniprot/TPM1_HUMAN TPM1_HUMAN]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Chick]]~~
	~~[[Category: Human]]~~
	[[Category: Frye, J]]		[[Category: Frye, J]]
	[[Category: Klenchin, V A]]		[[Category: Klenchin, V A]]

OCA at 20:22, 5 August 2016

2016-08-05T20:22:09Z

← Older revision		Revision as of 20:22, 5 August 2016
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	==Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle==		==Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle==
	<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mtu\|3mtu]], [[2g9j\|2g9j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mtu\|3mtu]], [[2g9j\|2g9j]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">XRCC4, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~9031 Gallus gallus~~]), MAPRE1, RCJMB04_6l6, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~9606 Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">XRCC4, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAPRE1, RCJMB04_6l6, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://pdbe.org/3mud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mud ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3mud" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Gallus gallus~~]]		[[Category: Chick]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Frye, J]]		[[Category: Frye, J]]
	[[Category: Klenchin, V A]]		[[Category: Klenchin, V A]]

OCA at 21:36, 25 December 2014

2014-12-25T21:36:13Z

← Older revision		Revision as of 21:36, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> [[http://www.uniprot.org/uniprot/TPM1_CHICK TPM1_CHICK]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:35, 18 December 2014

2014-12-18T08:35:27Z

← Older revision		Revision as of 08:35, 18 December 2014
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	~~{{STRUCTURE_3mud~~\| ~~PDB~~=3mud \| ~~SCENE~~= }}		==Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle==
	===~~Structure~~ of the ~~Tropomyosin Overlap Complex~~ from ~~Chicken Smooth Muscle~~===		<StructureSection load='3mud' size='340' side='right' caption='[[3mud]], [[Resolution\|resolution]] 2.20Å' scene=''>
	~~{{ABSTRACT_PUBMED_20465283}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3mud]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mtu\|3mtu]], [[2g9j\|2g9j]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">XRCC4, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]), MAPRE1, RCJMB04_6l6, TPM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mud RCSB], [http://www.ebi.ac.uk/pdbsum/3mud PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/3mud_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tropomyosin is a stereotypical alpha-helical coiled coil that polymerizes to form a filamentous macromolecular assembly that lies on the surface of F-actin. The interaction between the C-terminal and N-terminal segments on adjacent molecules is known as the overlap region. We report here two X-ray structures of the chicken smooth muscle tropomyosin overlap complex. A novel approach was used to stabilize the C-terminal and N-terminal fragments. Globular domains from both the human DNA ligase binding protein XRCC4 and bacteriophage varphi29 scaffolding protein Gp7 were fused to 37 and 28 C-terminal amino acid residues of tropomyosin, respectively, whereas the 29 N-terminal amino acids of tropomyosin were fused to the C-terminal helix bundle of microtubule binding protein EB1. The structures of both the XRCC4 and Gp7 fusion proteins complexed with the N-terminal EB1 fusion contain a very similar helix bundle in the overlap region that encompasses approximately 15 residues. The C-terminal coiled coil opens to allow formation of the helix bundle, which is stabilized by hydrophobic interactions. These structures are similar to that observed in the NMR structure of the rat skeletal overlap complex [Greenfield, N. J., et al. (2006) J. Mol. Biol. 364, 80-96]. The interactions between the N- and C-terminal coiled coils of smooth muscle tropomyosin show significant curvature, which differs somewhat between the two structures and implies flexibility in the overlap complex, at least in solution. This is likely an important attribute that allows tropomyosin to assemble around the actin filaments. These structures provide a molecular explanation for the role of N-acetylation in the assembly of native tropomyosin.

	~~==About this~~ Structure==		Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition .,Frye J, Klenchin VA, Rayment I Biochemistry. 2010 Jun 15;49(23):4908-20. PMID:20465283<ref>PMID:20465283</ref>
	~~[[3mud]] is a 4 chain structure with sequence~~ from ~~[http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus] and [http~~:~~//en~~.~~wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3MUD OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Tropomyosin\|Tropomyosin]]		*[[Tropomyosin\|Tropomyosin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:020465283<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Frye, J.]]		[[Category: Frye, J]]
	[[Category: Klenchin, V A.]]		[[Category: Klenchin, V A]]
	[[Category: Rayment, I.]]		[[Category: Rayment, I]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: Overlap complex]]		[[Category: Overlap complex]]
	[[Category: Tropomysoin]]		[[Category: Tropomysoin]]

OCA at 09:58, 11 March 2013

2013-03-11T09:58:20Z

← Older revision		Revision as of 09:58, 11 March 2013
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	~~[[Image:3mud.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3mud", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3mud\| PDB=3mud \| SCENE= }}		{{STRUCTURE_3mud\| PDB=3mud \| SCENE= }}

	===Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle===		===Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20465283}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20465283 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_20465283}}		{{ABSTRACT_PUBMED_20465283}}

	==About this Structure==		==About this Structure==
	[[3mud]] is a 4 chain structure ~~of [[Tropomyosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus~~,_homo_sapiens~~ Gallus gallus~~, homo sapiens~~] and [http://en.wikipedia.org/wiki/Homo_sapiens~~,gallus_gallus~~ Homo sapiens~~,gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA].		[[3mud]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA].

	==See Also==		==See Also==
	*[[Tropomyosin]]		*[[Tropomyosin\|Tropomyosin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20465283~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020465283</ref><references group="xtra"/>
	[[Category: Gallus gallus~~, homo sapiens~~]]		[[Category: Gallus gallus]]
	[[Category: Homo sapiens~~,gallus gallus~~]]		[[Category: Homo sapiens]]
	[[Category: Frye, J.]]		[[Category: Frye, J.]]
	[[Category: Klenchin, V A.]]		[[Category: Klenchin, V A.]]

OCA: Protected "3mud" [edit=sysop:move=sysop]

2010-12-27T01:34:25Z

Protected "3mud" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:34, 27 December 2010
(No difference)

OCA at 01:34, 27 December 2010

2010-12-27T01:34:24Z

← Older revision		Revision as of 01:34, 27 December 2010
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	~~{{Seed}}~~		[[Image:3mud.png\|left\|200px]]
	[[Image:3mud.~~jpg~~\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	~~3MUD~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Gallus_gallus,_homo_sapiens Gallus gallus, homo sapiens] and [http://en.wikipedia.org/wiki/Homo_sapiens,gallus_gallus Homo sapiens,gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA].		[[3mud]] is a 4 chain structure of [[Tropomyosin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus,_homo_sapiens Gallus gallus, homo sapiens] and [http://en.wikipedia.org/wiki/Homo_sapiens,gallus_gallus Homo sapiens,gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUD OCA].

			==See Also==
			*[[Tropomyosin]]

	==Reference==		==Reference==
Line 33:		Line 35:
	[[Category: Overlap complex]]		[[Category: Overlap complex]]
	[[Category: Tropomysoin]]		[[Category: Tropomysoin]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:52:34 2010''~~

OCA at 04:47, 23 June 2010

2010-06-23T04:47:16Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3mud is ON HOLD
+<!--
-Authors: Klenchin, V.A., Frye, J., Rayment, I.
+===Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:47:30 2010''
+<!--