3mxv - Revision history

OCA at 06:31, 27 November 2024

2024-11-27T06:31:06Z

← Older revision		Revision as of 06:31, 27 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxv_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:03, 6 September 2023

2023-09-06T09:03:54Z

← Older revision		Revision as of 09:03, 6 September 2023
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	<StructureSection load='3mxv' size='340' side='right'caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3mxv' size='340' side='right'caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3MXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXV FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3mxw\|3mxw]]~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [~~http~~://pdbe.org/3mxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [https://pdbe.org/3mxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [https://www.ebi.ac.uk/pdbsum/3mxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Hymowitz~~, S G~~]]		[[Category: Hymowitz SG]]
	[[Category: Maun~~, H R]]~~		[[Category: Maun HR]]
	~~[[Category: Antibody]]~~
	~~[[Category: Chimera]]~~
	~~[[Category: Fab fragment]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Sonic hedgehog~~]]

OCA at 09:00, 21 October 2020

2020-10-21T09:00:03Z

← Older revision		Revision as of 09:00, 21 October 2020
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	==Crystal structure of fab fragment of anti-Shh 5E1 chimera==		==Crystal structure of fab fragment of anti-Shh 5E1 chimera==
	<StructureSection load='3mxv' size='340' side='right' caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3mxv' size='340' side='right'caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mxw\|3mxw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mxw\|3mxw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [http://pdbe.org/3mxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [http://www.ebi.ac.uk/pdbsum/3mxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [http://pdbe.org/3mxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [http://www.ebi.ac.uk/pdbsum/3mxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[Sandbox 20009\|Sandbox 20009]]
			*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hymowitz, S G]]		[[Category: Hymowitz, S G]]

OCA at 13:26, 16 January 2019

2019-01-16T13:26:27Z

← Older revision		Revision as of 13:26, 16 January 2019
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxv_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:53, 10 December 2016

2016-12-10T03:53:23Z

← Older revision		Revision as of 03:53, 10 December 2016
Line 1:		Line 1:

	==Crystal structure of fab fragment of anti-Shh 5E1 chimera==		==Crystal structure of fab fragment of anti-Shh 5E1 chimera==
	<StructureSection load='3mxv' size='340' side='right' caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3mxv' size='340' side='right' caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mxw\|3mxw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mxw\|3mxw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [http://www.ebi.ac.uk/pdbsum/3mxv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [http://pdbe.org/3mxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [http://www.ebi.ac.uk/pdbsum/3mxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mxv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3mxv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[~~Antibody~~\|~~Antibody~~]]		*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens]]~~		[[Category: Lk3 transgenic mice]]
	~~[[Category: Mus musculus~~]]
	[[Category: Hymowitz, S G]]		[[Category: Hymowitz, S G]]
	[[Category: Maun, H R]]		[[Category: Maun, H R]]

OCA at 09:32, 9 December 2014

2014-12-09T09:32:46Z

← Older revision		Revision as of 09:32, 9 December 2014
Line 1:		Line 1:
	[[Image:~~3mxv~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of fab fragment of anti-Shh 5E1 chimera==
			<StructureSection load='3mxv' size='340' side='right' caption='[[3mxv]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXV FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mxw\|3mxw]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxv RCSB], [http://www.ebi.ac.uk/pdbsum/3mxv PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxv_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration. Dysregulation of this pathway is associated with several types of cancer. The monoclonal antibody 5E1 is a Hh pathway inhibitor that has been extensively used to elucidate vertebrate Hh biology due to its ability to block binding of the three mammalian Hh homologs to the receptor, Patched1 (Ptc1). Here, we engineered a murine:human chimeric 5E1 (ch5E1) with similar Hh-binding properties to the original murine antibody. Using biochemical, biophysical, and x-ray crystallographic studies, we show that, like the regulatory receptors Cdon and Hedgehog-interacting protein (Hhip), ch5E1 binding to Sonic hedgehog (Shh) is enhanced by calcium ions. In the presence of calcium and zinc ions, the ch5E1 binding affinity increases 10-20-fold to tighter than 1 nm primarily because of a decrease in the dissociation rate. The co-crystal structure of Shh bound to the Fab fragment of ch5E1 reveals that 5E1 binds at the pseudo-active site groove of Shh with an epitope that largely overlaps with the binding site of its natural receptor antagonist Hhip. Unlike Hhip, the side chains of 5E1 do not directly coordinate the Zn(2+) cation in the pseudo-active site, despite the modest zinc-dependent increase in 5E1 affinity for Shh. Furthermore, to our knowledge, the ch5E1 Fab-Shh complex represents the first structure of an inhibitor antibody bound to a metalloprotease fold.

	~~{{STRUCTURE_3mxv\| PDB=3mxv \| SCENE= }}~~		Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.,Maun HR, Wen X, Lingel A, de Sauvage FJ, Lazarus RA, Scales SJ, Hymowitz SG J Biol Chem. 2010 Aug 20;285(34):26570-80. Epub 2010 May 26. PMID:20504762<ref>PMID:20504762</ref>

	~~===Crystal structure of fab fragment~~ of ~~anti-Shh 5E1 chimera===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20504762}}~~

	~~==About this Structure==~~
	~~[[3mxv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].~~

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:020504762<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G]]
	[[Category: Maun, H R.]]		[[Category: Maun, H R]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Chimera]]		[[Category: Chimera]]

OCA at 16:25, 20 October 2012

2012-10-20T16:25:17Z

← Older revision		Revision as of 16:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3mxv]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus~~,_homo_sapiens~~ Mus musculus~~, homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].		[[3mxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:020504762</ref><references group="xtra"/>		<ref group="xtra">PMID:020504762</ref><references group="xtra"/>
	[[Category: Mus musculus~~, homo sapiens~~]]		[[Category: Homo sapiens]]
			[[Category: Mus musculus]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G.]]
	[[Category: Maun, H R.]]		[[Category: Maun, H R.]]

OCA: Protected "3mxv" [edit=sysop:move=sysop]

2012-07-26T21:38:11Z

Protected "3mxv" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:38, 26 July 2012
(No difference)

OCA at 21:38, 26 July 2012

2012-07-26T21:38:10Z

← Older revision		Revision as of 21:38, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3mxv.png\|left\|200px]]		[[Image:3mxv.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3mxv", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3mxv\| PDB=3mxv \| SCENE= }}		{{STRUCTURE_3mxv\| PDB=3mxv \| SCENE= }}

	===Crystal structure of fab fragment of anti-Shh 5E1 chimera===		===Crystal structure of fab fragment of anti-Shh 5E1 chimera===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20504762}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20504762 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20504762}}		{{ABSTRACT_PUBMED_20504762}}

	==About this Structure==		==About this Structure==
	~~3MXV~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].		[[3mxv]] is a 2 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].

			==See Also==
			*[[Antibody\|Antibody]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20504762~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020504762</ref><references group="xtra"/>
	[[Category: Mus musculus, homo sapiens]]		[[Category: Mus musculus, homo sapiens]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G.]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Sonic hedgehog]]		[[Category: Sonic hedgehog]]

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OCA at 20:05, 11 August 2010

2010-08-11T20:05:33Z

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	===Crystal structure of fab fragment of anti-Shh 5E1 chimera===		===Crystal structure of fab fragment of anti-Shh 5E1 chimera===


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			{{ABSTRACT_PUBMED_20504762}}

	==About this Structure==		==About this Structure==
	3MXV is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].		3MXV is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXV OCA].

			==Reference==
			<ref group="xtra">PMID:20504762</ref><references group="xtra"/>
	[[Category: Mus musculus, homo sapiens]]		[[Category: Mus musculus, homo sapiens]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G.]]
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	[[Category: Sonic hedgehog]]		[[Category: Sonic hedgehog]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 26 08~~:35:45 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:12:49 2010''