3nit - Revision history

OCA at 08:32, 20 March 2024

2024-03-20T08:32:31Z

← Older revision		Revision as of 08:32, 20 March 2024
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	<StructureSection load='3nit' size='340' side='right'caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3nit' size='340' side='right'caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIT FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3nih\|3nih]], [[3nii\|3nii]], [[3nij\|3nij]], [[3nik\|3nik]], [[3nil\|3nil]], [[3nim\|3nim]], [[3nin\|3nin]], [[3nis\|3nis]]~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [~~http~~://pdbe.org/3nit PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nit PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nit ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [https://pdbe.org/3nit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [https://www.ebi.ac.uk/pdbsum/3nit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST]] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.		[https://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nit ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nit ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The N-end rule pathway is a regulated proteolytic system that targets proteins containing destabilizing N-terminal residues (N-degrons) for ubiquitination and proteasomal degradation in eukaryotes. The N-degrons of type 1 substrates contain an N-terminal basic residue that is recognized by the UBR box domain of the E3 ubiquitin ligase UBR1. We describe structures of the UBR box of Saccharomyces cerevisiae UBR1 alone and in complex with N-degron peptides, including that of the cohesin subunit Scc1, which is cleaved and targeted for degradation at the metaphase-anaphase transition. The structures reveal a previously unknown protein fold that is stabilized by a novel binuclear zinc center. N-terminal arginine, lysine or histidine side chains of the N-degron are coordinated in a multispecific binding pocket. Unexpectedly, the structures together with our in vitro biochemical and in vivo pulse-chase analyses reveal a previously unknown modulation of binding specificity by the residue at position 2 of the N-degron.

	Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.,Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240<ref>PMID:20835240</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]		*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Choi~~, W S~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Jeong, B C]]		[[Category: Choi WS]]
	[[Category: Lee, M R]]		[[Category: Jeong B-C]]
	[[Category: Song~~, H K]]~~		[[Category: Lee M-R]]
	~~[[Category: E3 ubiquitin ligase]]~~		[[Category: Song HK]]
	~~[[Category: Ligase]]~~
	~~[[Category: Metal binding protein]]~~
	~~[[Category: N-end rule]]~~
	~~[[Category: Ubr box]]~~
	~~[[Category: Zinc-binding protein~~]]

OCA at 18:05, 14 August 2019

2019-08-14T18:05:59Z

← Older revision		Revision as of 18:05, 14 August 2019
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	==The structure of UBR box (native1)==		==The structure of UBR box (native1)==
	<StructureSection load='3nit' size='340' side='right' caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3nit' size='340' side='right'caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIT FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3nit_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3nit_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Choi, W S]]		[[Category: Choi, W S]]
	[[Category: Jeong, B C]]		[[Category: Jeong, B C]]

OCA at 08:30, 8 November 2017

2017-11-08T08:30:36Z

← Older revision		Revision as of 08:30, 8 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:03, 4 August 2016

2016-08-04T22:03:54Z

← Older revision		Revision as of 22:03, 4 August 2016
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	==The structure of UBR box (native1)==		==The structure of UBR box (native1)==
	<StructureSection load='3nit' size='340' side='right' caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3nit' size='340' side='right' caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nih\|3nih]], [[3nii\|3nii]], [[3nij\|3nij]], [[3nik\|3nik]], [[3nil\|3nil]], [[3nim\|3nim]], [[3nin\|3nin]], [[3nis\|3nis]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nih\|3nih]], [[3nii\|3nii]], [[3nij\|3nij]], [[3nik\|3nik]], [[3nil\|3nil]], [[3nim\|3nim]], [[3nin\|3nin]], [[3nis\|3nis]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [http://www.ebi.ac.uk/pdbsum/3nit PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [http://pdbe.org/3nit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [http://www.ebi.ac.uk/pdbsum/3nit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nit ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3nit" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Choi, W S]]		[[Category: Choi, W S]]
	[[Category: Jeong, B C]]		[[Category: Jeong, B C]]

OCA at 13:31, 25 December 2014

2014-12-25T13:31:12Z

← Older revision		Revision as of 13:31, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [http://www.ebi.ac.uk/pdbsum/3nit PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [http://www.ebi.ac.uk/pdbsum/3nit PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST]] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:21, 18 December 2014

2014-12-18T15:21:58Z

← Older revision		Revision as of 15:21, 18 December 2014
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	~~{{STRUCTURE_3nit~~\| ~~PDB~~=3nit \| ~~SCENE~~= }}		==The structure of UBR box (native1)==
	===~~The~~ structure of ~~UBR box (native1)~~===		<StructureSection load='3nit' size='340' side='right' caption='[[3nit]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{ABSTRACT_PUBMED_20835240}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NIT FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nih\|3nih]], [[3nii\|3nii]], [[3nij\|3nij]], [[3nik\|3nik]], [[3nil\|3nil]], [[3nim\|3nim]], [[3nin\|3nin]], [[3nis\|3nis]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nit RCSB], [http://www.ebi.ac.uk/pdbsum/3nit PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3nit_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The N-end rule pathway is a regulated proteolytic system that targets proteins containing destabilizing N-terminal residues (N-degrons) for ubiquitination and proteasomal degradation in eukaryotes. The N-degrons of type 1 substrates contain an N-terminal basic residue that is recognized by the UBR box domain of the E3 ubiquitin ligase UBR1. We describe structures of the UBR box of Saccharomyces cerevisiae UBR1 alone and in complex with N-degron peptides, including that of the cohesin subunit Scc1, which is cleaved and targeted for degradation at the metaphase-anaphase transition. The structures reveal a previously unknown protein fold that is stabilized by a novel binuclear zinc center. N-terminal arginine, lysine or histidine side chains of the N-degron are coordinated in a multispecific binding pocket. Unexpectedly, the structures together with our in vitro biochemical and in vivo pulse-chase analyses reveal a previously unknown modulation of binding specificity by the residue at position 2 of the N-degron.

	~~==Function==~~		Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.,Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240<ref>PMID:20835240</ref>
	~~[[http://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST]] Ubiquitin ligase protein which is a component~~ of ~~the~~ N-end rule ~~pathway~~. ~~Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule~~, ~~leading to their ubiquitination and subsequent degradation~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3nit]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA].~~		</div>

	==See Also==		==See Also==
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]		*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:020835240</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Choi, W S.]]		[[Category: Choi, W S]]
	[[Category: Jeong, B C.]]		[[Category: Jeong, B C]]
	[[Category: Lee, M R.]]		[[Category: Lee, M R]]
	[[Category: Song, H K.]]		[[Category: Song, H K]]
	[[Category: E3 ubiquitin ligase]]		[[Category: E3 ubiquitin ligase]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA: Protected "3nit" [edit=sysop:move=sysop]

2013-04-24T11:47:44Z

Protected "3nit" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:47, 24 April 2013
(No difference)

OCA at 11:47, 24 April 2013

2013-04-24T11:47:41Z

← Older revision		Revision as of 11:47, 24 April 2013
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	~~{{Seed}}~~
	~~[[Image:3nit.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3nit", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3nit\| PDB=3nit \| SCENE= }}		{{STRUCTURE_3nit\| PDB=3nit \| SCENE= }}

	===The structure of UBR box (native1)===		===The structure of UBR box (native1)===
			{{ABSTRACT_PUBMED_20835240}}

			==Function==
			[[http://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST]] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

	~~<!--~~		==About this Structure==
	~~The line below~~ this ~~paragraph, {{ABSTRACT_PUBMED_20835240}}, adds the Publication Abstract to the page~~		[[3nit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA].
	~~(as it appears on PubMed at~~ http://~~www~~.~~pubmed~~.~~gov), where 20835240~~ is ~~the PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_20835240}}~~

	==~~About this Structure~~==		==See Also==
	~~3NIT is a 1 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA~~].		*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20835240~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020835240</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Choi, W S.]]		[[Category: Choi, W S.]]
Line 35:		Line 25:
	[[Category: Ubr box]]		[[Category: Ubr box]]
	[[Category: Zinc-binding protein]]		[[Category: Zinc-binding protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:16:09 2010''~~

OCA at 11:07, 22 September 2010

2010-09-22T11:07:10Z

← Older revision		Revision as of 11:07, 22 September 2010
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	{{Seed}}		{{Seed}}
	[[Image:3nit.~~jpg~~\|left\|200px]]		[[Image:3nit.png\|left\|200px]]

	<!--		<!--
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	===The structure of UBR box (native1)===		===The structure of UBR box (native1)===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20835240}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20835240 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_20835240}}

	==About this Structure==		==About this Structure==
	3NIT is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA].		3NIT is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIT OCA].

			==Reference==
			<ref group="xtra">PMID:20835240</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Choi, W S.]]		[[Category: Choi, W S.]]
Line 27:		Line 36:
	[[Category: Zinc-binding protein]]		[[Category: Zinc-binding protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~15 10~~:51:40 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:16:09 2010''

OCA at 07:42, 15 September 2010

2010-09-15T07:42:59Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3nit is ON HOLD  until Paper Publication
+<!--
-Authors: Choi, W.S., Jeong, B.-C., Lee, M.-R., Song, H.K.
+===The structure of UBR box (native1)===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:04:27 2010''
+==About this Structure==