3o7a - Revision history

OCA at 09:30, 6 September 2023

2023-09-06T09:30:04Z

← Older revision		Revision as of 09:30, 6 September 2023
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	<StructureSection load='3o7a' size='340' side='right'caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='3o7a' size='340' side='right'caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O7A FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.67Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[3o70\|3o70]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [https://pdbe.org/3o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [https://www.ebi.ac.uk/pdbsum/3o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7a ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [~~http~~://pdbe.org/3o7a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3o7a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PHF13_HUMAN PHF13_HUMAN]] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>		[https://www.uniprot.org/uniprot/PHF13_HUMAN PHF13_HUMAN] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Xenopus laevis]]
	[[Category: Bian~~, C B~~]]		[[Category: Arrowsmith CH]]
	[[Category: Bochkarev, A]]		[[Category: Bian CB]]
	[[Category: Bountra, C]]		[[Category: Bochkarev A]]
	[[Category: Edwards~~, A M~~]]		[[Category: Bountra C]]
	[[Category: Lam, R]]		[[Category: Edwards AM]]
	[[Category: Min, J]]		[[Category: Lam R]]
	~~[[Category: Structural genomic~~]]		[[Category: Min J]]
	[[Category: Weigelt, J]]		[[Category: Weigelt J]]
	[[Category: Xu, C]]		[[Category: Xu C]]
	~~[[Category: Nuclear protein]]~~
	~~[[Category: Phd domain]]~~
	~~[[Category: Phf13]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Zinc finger~~]]

OCA at 08:10, 4 November 2020

2020-11-04T08:10:33Z

← Older revision		Revision as of 08:10, 4 November 2020
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	==Crystal structure of PHF13 in complex with H3K4me3==		==Crystal structure of PHF13 in complex with H3K4me3==
	<StructureSection load='3o7a' size='340' side='right' caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='3o7a' size='340' side='right'caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3O7A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://pdbe.org/3o7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://pdbe.org/3o7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bian, C B]]		[[Category: Bian, C B]]

OCA at 10:14, 30 January 2019

2019-01-30T10:14:58Z

← Older revision		Revision as of 10:14, 30 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/3o7a_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/3o7a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Lam, R]]		[[Category: Lam, R]]
	[[Category: Min, J]]		[[Category: Min, J]]
			[[Category: Structural genomic]]
	[[Category: Weigelt, J]]		[[Category: Weigelt, J]]
	[[Category: Xu, C]]		[[Category: Xu, C]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Sgc]]		[[Category: Sgc]]
	~~[[Category: Structural genomic]]~~
	[[Category: Zinc finger]]		[[Category: Zinc finger]]

OCA at 02:31, 13 July 2016

2016-07-13T02:31:25Z

← Older revision		Revision as of 02:31, 13 July 2016
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://pdbe.org/3o7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://pdbe.org/3o7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:51, 23 June 2016

2016-06-23T15:51:38Z

← Older revision		Revision as of 15:51, 23 June 2016
Line 1:		Line 1:

	==Crystal structure of PHF13 in complex with H3K4me3==		==Crystal structure of PHF13 in complex with H3K4me3==
	<StructureSection load='3o7a' size='340' side='right' caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='3o7a' size='340' side='right' caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O7A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://pdbe.org/3o7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~Q59FB6_HUMAN Q59FB6_HUMAN~~]] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>		[[http://www.uniprot.org/uniprot/PHF13_HUMAN PHF13_HUMAN]] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o7a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			PHF13 is a chromatin affiliated protein with a functional role in differentiation, cell division, DNA damage response and higher chromatin order. To gain insight into PHF13's ability to modulate these processes, we elucidate the mechanisms targeting PHF13 to chromatin, its genome wide localization and its molecular chromatin context. Size exclusion chromatography, mass spectrometry, X-ray crystallography and ChIP sequencing demonstrate that PHF13 binds chromatin in a multivalent fashion via direct interactions with H3K4me2/3 and DNA, and indirectly via interactions with PRC2 and RNA PolII. Furthermore, PHF13 depletion disrupted the interactions between PRC2, RNA PolII S5P, H3K4me3 and H3K27me3 and resulted in the up and down regulation of genes functionally enriched in transcriptional regulation, DNA binding, cell cycle, differentiation and chromatin organization. Together our findings argue that PHF13 is an H3K4me2/3 molecular reader and transcriptional co-regulator, affording it the ability to impact different chromatin processes.

			PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.,Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, Di Croce L, Min J, Will H, Kinkley S Elife. 2016 May 25;5. pii: e10607. doi: 10.7554/eLife.10607. PMID:27223324<ref>PMID:27223324</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 3o7a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bian, C B]]		[[Category: Bian, C B]]

OCA at 05:04, 25 December 2014

2014-12-25T05:04:18Z

← Older revision		Revision as of 05:04, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q59FB6_HUMAN Q59FB6_HUMAN]] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:09, 19 December 2014

2014-12-19T07:09:32Z

← Older revision		Revision as of 07:09, 19 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3o7a\| PDB=3o7a \| SCENE= }}~~		==Crystal structure of PHF13 in complex with H3K4me3==
	===Crystal structure of PHF13 in complex with H3K4me3===		<StructureSection load='3o7a' size='340' side='right' caption='[[3o7a]], [[Resolution\|resolution]] 1.67Å' scene=''>
			== Structural highlights ==
	==~~Function~~==		<table><tr><td colspan='2'>[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O7A FirstGlance]. <br>
	[[~~http://www.uniprot.org/uniprot/Q59FB6_HUMAN Q59FB6_HUMAN~~]] ~~Modulates chromatin structure~~. ~~Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref~~>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	==~~About this Structure~~==		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3o70\|3o70]]</td></tr>
	[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA].		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o7a RCSB], [http://www.ebi.ac.uk/pdbsum/3o7a PDBsum]</span></td></tr>
			</table>
	==~~Reference~~==		== Evolutionary Conservation ==
	<~~references group~~="~~xtra~~"/><~~references~~/>		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/3o7a_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Bian, C B.]]		[[Category: Bian, C B]]
	[[Category: Bochkarev, A.]]		[[Category: Bochkarev, A]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Lam, R.]]		[[Category: Lam, R]]
	[[Category: Min, J.]]		[[Category: Min, J]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Xu, C.]]		[[Category: Xu, C]]
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Phd domain]]		[[Category: Phd domain]]
Line 26:		Line 36:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Zinc finger]]		[[Category: Zinc finger]]

OCA: Protected "3o7a" [edit=sysop:move=sysop]

2013-04-24T11:51:14Z

Protected "3o7a" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:51, 24 April 2013
(No difference)

OCA at 11:51, 24 April 2013

2013-04-24T11:51:09Z

← Older revision		Revision as of 11:51, 24 April 2013
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	~~{{Seed}}~~
	~~[[Image:3o7a.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3o7a", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3o7a\| PDB=3o7a \| SCENE= }}		{{STRUCTURE_3o7a\| PDB=3o7a \| SCENE= }}

	===Crystal structure of PHF13 in complex with H3K4me3===		===Crystal structure of PHF13 in complex with H3K4me3===

			==Function==
			[[http://www.uniprot.org/uniprot/Q59FB6_HUMAN Q59FB6_HUMAN]] Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<ref>PMID:19638409</ref>

	==About this Structure==		==About this Structure==
	~~3O7A~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA].		[[3o7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7A OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 33:		Line 28:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Zinc finger]]		[[Category: Zinc finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:07:45 2010''~~

OCA at 02:58, 6 October 2010

2010-10-06T02:58:15Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3o7a is ON HOLD  until Paper Publication
+<!--
-Authors: Bian, C.B., Lam, R., Xu, C., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bochkarev, A., Min, J.
+===Crystal structure of PHF13 in complex with H3K4me3===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:55:34 2010''
+==About this Structure==