3ouk - Revision history

OCA at 11:18, 21 February 2024

2024-02-21T11:18:53Z

← Older revision		Revision as of 11:18, 21 February 2024
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	<StructureSection load='3ouk' size='340' side='right'caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='3ouk' size='340' side='right'caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OUK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OUK FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.402Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MT4029, Rv3910 ([https://www.ncbi.nlm~~.~~nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83332 MYCTU])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [https://pdbe.org/3ouk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [https://www.ebi.ac.uk/pdbsum/3ouk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [https://pdbe.org/3ouk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [https://www.ebi.ac.uk/pdbsum/3ouk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~MVIN_MYCTO MVIN_MYCTO]~~] Essential for cell growth and peptidoglycan synthesis.		[https://www.uniprot.org/uniprot/MVINL_MYCTU MVINL_MYCTU] Essential for cell growth and peptidoglycan synthesis.<ref>PMID:22275220</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms regulating this dynamic process remain obscure. Here, we describe a phosphorylation-dependent regulatory complex that controls peptidoglycan (PG) biosynthesis in Mycobacterium tuberculosis. We found that PknB, a PG-responsive Ser-Thr protein kinase (STPK), initiates complex assembly by phosphorylating a kinase-like domain in the essential PG biosynthetic protein, MviN. This domain was structurally diverged from active kinases and did not mediate phosphotransfer. Threonine phosphorylation of the pseudokinase domain recruited the FhaA protein through its forkhead-associated (FHA) domain. The crystal structure of this phosphorylated pseudokinase-FHA domain complex revealed the basis of FHA domain recognition, which included unexpected contacts distal to the phosphorylated threonine. Conditional degradation of these proteins in mycobacteria demonstrated that MviN was essential for growth and PG biosynthesis and that FhaA regulated these processes at the cell poles and septum. Controlling this spatially localized PG regulatory complex is only one of several cellular roles ascribed to PknB, suggesting that the capacity to coordinate signaling across multiple processes is an important feature conserved between eukaryotic and prokaryotic STPK networks.

	A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.,Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T Sci Signal. 2012 Jan 24;5(208):ra7. PMID:22275220<ref>PMID:22275220</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3ouk" style="background-color:#fffaf0;"></div~~>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Myctu~~]]		[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Alber, T]]		[[Category: Alber T]]
	[[Category: Gee~~, C L]]~~		[[Category: Gee CL]]
	~~[[Category: Membrane protein]]~~
	~~[[Category: Peptidoglycan]]~~
	~~[[Category: Pseudokinase]]~~
	~~[[Category: Regulation]]~~
	~~[[Category: Ser/thr kinase]]~~
	~~[[Category: Transferase~~]]

OCA at 10:57, 18 May 2022

2022-05-18T10:57:56Z

← Older revision		Revision as of 10:57, 18 May 2022
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	==Crystal structure of Rv3910 from Mycobacterium Tuberculosis==		==Crystal structure of Rv3910 from Mycobacterium Tuberculosis==
	<StructureSection load='3ouk' size='340' side='right' caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='3ouk' size='340' side='right'caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OUK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OUK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [~~http~~://pdbe.org/3ouk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ouk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [https://pdbe.org/3ouk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [https://www.ebi.ac.uk/pdbsum/3ouk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MVIN_MYCTO MVIN_MYCTO]] Essential for cell growth and peptidoglycan synthesis.		[[https://www.uniprot.org/uniprot/MVIN_MYCTO MVIN_MYCTO]] Essential for cell growth and peptidoglycan synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Alber, T]]		[[Category: Alber, T]]

OCA at 01:29, 5 August 2016

2016-08-05T01:29:02Z

← Older revision		Revision as of 01:29, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of Rv3910 from Mycobacterium Tuberculosis==		==Crystal structure of Rv3910 from Mycobacterium Tuberculosis==
	<StructureSection load='3ouk' size='340' side='right' caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='3ouk' size='340' side='right' caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [http://www.ebi.ac.uk/pdbsum/3ouk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [http://pdbe.org/3ouk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [http://www.ebi.ac.uk/pdbsum/3ouk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ouk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~O05435_MYCTU O05435_MYCTU~~]] Essential for cell growth and peptidoglycan synthesis.		[[http://www.uniprot.org/uniprot/MVIN_MYCTO MVIN_MYCTO]] Essential for cell growth and peptidoglycan synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ouk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium tuberculosis~~]]		[[Category: Myctu]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Gee, C L]]		[[Category: Gee, C L]]

OCA at 22:43, 3 January 2015

2015-01-03T22:43:02Z

← Older revision		Revision as of 22:43, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [http://www.ebi.ac.uk/pdbsum/3ouk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [http://www.ebi.ac.uk/pdbsum/3ouk PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/O05435_MYCTU O05435_MYCTU]] Essential for cell growth and peptidoglycan synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.,Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T Sci Signal. 2012 Jan 24;5(208):ra7. PMID:22275220<ref>PMID:22275220</ref>		A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.,Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T Sci Signal. 2012 Jan 24;5(208):ra7. PMID:22275220<ref>PMID:22275220</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alber, T.]]		[[Category: Alber, T]]
	[[Category: Gee, C L.]]		[[Category: Gee, C L]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Peptidoglycan]]		[[Category: Peptidoglycan]]

OCA at 10:30, 28 May 2014

2014-05-28T10:30:39Z

← Older revision		Revision as of 10:30, 28 May 2014
Line 1:		Line 1:
	[[~~Image~~:~~3ouk~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Crystal structure of Rv3910 from Mycobacterium Tuberculosis==
			<StructureSection load='3ouk' size='340' side='right' caption='[[3ouk]], [[Resolution\|resolution]] 3.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3ouk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3otv\|3otv]], [[3oun\|3oun]], [[3uqc\|3uqc]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT4029, Rv3910 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ouk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ouk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ouk RCSB], [http://www.ebi.ac.uk/pdbsum/3ouk PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms regulating this dynamic process remain obscure. Here, we describe a phosphorylation-dependent regulatory complex that controls peptidoglycan (PG) biosynthesis in Mycobacterium tuberculosis. We found that PknB, a PG-responsive Ser-Thr protein kinase (STPK), initiates complex assembly by phosphorylating a kinase-like domain in the essential PG biosynthetic protein, MviN. This domain was structurally diverged from active kinases and did not mediate phosphotransfer. Threonine phosphorylation of the pseudokinase domain recruited the FhaA protein through its forkhead-associated (FHA) domain. The crystal structure of this phosphorylated pseudokinase-FHA domain complex revealed the basis of FHA domain recognition, which included unexpected contacts distal to the phosphorylated threonine. Conditional degradation of these proteins in mycobacteria demonstrated that MviN was essential for growth and PG biosynthesis and that FhaA regulated these processes at the cell poles and septum. Controlling this spatially localized PG regulatory complex is only one of several cellular roles ascribed to PknB, suggesting that the capacity to coordinate signaling across multiple processes is an important feature conserved between eukaryotic and prokaryotic STPK networks.

	~~<!--~~		A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.,Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T Sci Signal. 2012 Jan 24;5(208):ra7. PMID:22275220<ref>PMID:22275220</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3ouk"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter~~ (~~which sets the initial scene displayed when the page is loaded~~),
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3ouk\| PDB=3ouk \| SCENE= }}~~

	~~===Crystal structure~~ of ~~Rv3910 from Mycobacterium Tuberculosis===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22275220}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22275220 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22275220}}~~

	~~==About this Structure==~~
	~~[[3ouk]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUK OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022275220<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alber, T.]]		[[Category: Alber, T.]]

OCA: Protected "3ouk" [edit=sysop:move=sysop]

2012-02-08T06:32:12Z

Protected "3ouk" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:32, 8 February 2012
(No difference)

OCA at 06:32, 8 February 2012

2012-02-08T06:32:07Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3ouk.jpg|left|200px]]
-The entry 3ouk is ON HOLD  until Paper Publication
+<!--
-Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC)
+===Crystal structure of Rv3910 from Mycobacterium Tuberculosis===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 10:03:48 2010''
+<!--

OCA at 06:53, 3 November 2010

2010-11-03T06:53:08Z

← Older revision		Revision as of 06:53, 3 November 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3ouk is ON HOLD		The entry 3ouk is ON HOLD until Paper Publication

	Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC)		Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC)
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	Description: Crystal structure of Rv3910 from Mycobacterium Tuberculosis		Description: Crystal structure of Rv3910 from Mycobacterium Tuberculosis

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 22 14~~:35:10 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 10:03:48 2010''

OCA: New page: '''Unreleased structure''' The entry 3ouk is ON HOLD Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC) Description: Crystal structure of Rv3910 from Mycobacteriu...

2010-09-22T11:26:11Z

New page: '''Unreleased structure''' The entry 3ouk is ON HOLD Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC) Description: Crystal structure of Rv3910 from Mycobacteriu...

New page

'''Unreleased structure'''

The entry 3ouk is ON HOLD

Authors: Gee, C.L., Alber, T., TB Structural Genomics Consortium (TBSGC)

Description: Crystal structure of Rv3910 from Mycobacterium Tuberculosis

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:35:10 2010''