3pcb - Revision history

OCA at 09:48, 25 December 2024

2024-12-25T09:48:38Z

← Older revision		Revision as of 09:48, 25 December 2024
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	<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PCB FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=~~BME~~:~~BETA~~-~~MERCAPTOETHANOL~~'>~~BME~~</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [https://pdbe.org/3pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [https://www.ebi.ac.uk/pdbsum/3pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [https://pdbe.org/3pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [https://www.ebi.ac.uk/pdbsum/3pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcb ProSAT]</span></td></tr>
	</table>		</table>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/3pcb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/3pcb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:05, 27 September 2023

2023-09-27T07:05:23Z

← Older revision		Revision as of 07:05, 27 September 2023
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	<StructureSection load='3pcb' size='340' side='right'caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3pcb' size='340' side='right'caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [~~http~~://pdbe.org/3pcb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pcb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [https://pdbe.org/3pcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [https://www.ebi.ac.uk/pdbsum/3pcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PCXA_PSEPU PCXA_PSEPU~~]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway. [[http://www.uniprot.org/uniprot/PCXB_PSEPU PCXB_PSEPU]~~] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.		[https://www.uniprot.org/uniprot/PCXA_PSEPU PCXA_PSEPU] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Protocatechuate 3,4-dioxygenase]]~~
	[[Category: Pseudomonas putida]]		[[Category: Pseudomonas putida]]
	[[Category: Elango, N]]		[[Category: Elango N]]
	[[Category: Lipscomb~~, J D~~]]		[[Category: Lipscomb JD]]
	[[Category: Ohlendorf~~, D H~~]]		[[Category: Ohlendorf DH]]
	[[Category: Orville~~, A M]]~~		[[Category: Orville AM]]
	~~[[Category: Dioxygenase]]~~
	~~[[Category: Iron]]~~
	~~[[Category: Metalloprotein]]~~
	~~[[Category: Nonheme]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 13:51, 25 December 2019

2019-12-25T13:51:26Z

← Older revision		Revision as of 13:51, 25 December 2019
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	==STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE==		==STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE==
	<StructureSection load='3pcb' size='340' side='right' caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3pcb' size='340' side='right'caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PCB FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/3pcb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/3pcb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3pcb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pcb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Protocatechuate 3,4-dioxygenase]]		[[Category: Protocatechuate 3,4-dioxygenase]]
	[[Category: Pseudomonas putida]]		[[Category: Pseudomonas putida]]

OCA at 07:16, 29 November 2017

2017-11-29T07:16:52Z

← Older revision		Revision as of 07:16, 29 November 2017
Line 1:		Line 1:

	==STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE==		==STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE==
	<StructureSection load='3pcb' size='340' side='right' caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3pcb' size='340' side='right' caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://pdbe.org/3pcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://pdbe.org/3pcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3pcb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pcb" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Dioxygenase\|Dioxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:04, 10 February 2016

2016-02-10T03:04:52Z

← Older revision		Revision as of 03:04, 10 February 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://pdbe.org/3pcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3pcb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3pcb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:21, 25 December 2014

2014-12-25T11:21:40Z

← Older revision		Revision as of 11:21, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PCXA_PSEPU PCXA_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway. [[http://www.uniprot.org/uniprot/PCXB_PSEPU PCXB_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:55, 19 December 2014

2014-12-19T06:55:49Z

← Older revision		Revision as of 06:55, 19 December 2014
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	~~{{STRUCTURE_3pcb~~\| ~~PDB~~=3pcb \| ~~SCENE~~= }}		==STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE==
	===~~STRUCTURE OF PROTOCATECHUATE~~ 3,4-~~DIOXYGENASE COMPLEXED WITH~~ 3-~~HYDROXYBENZOATE~~===		<StructureSection load='3pcb' size='340' side='right' caption='[[3pcb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	~~{{ABSTRACT_PUBMED_9254599}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3pcb]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PCB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HB:3-HYDROXYBENZOIC+ACID'>3HB</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protocatechuate_3,4-dioxygenase Protocatechuate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.3 1.13.11.3] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pcb RCSB], [http://www.ebi.ac.uk/pdbsum/3pcb PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/3pcb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis, cis-muconate. Crystal structures of Pseudomonas putida3,4-PCD [quaternary structure of (alphabetaFe3+)12] complexed with seven competitive inhibitors [3-hydroxyphenylacetate (MHP), 4-hydroxyphenylacetate (PHP), 3-hydroxybenzoate (MHB), 4-hydroxybenzoate (PHB), 3-fluoro-4-hydroxybenzoate (FHB), 3-chloro-4-hydroxybenzoate (CHB), and 3-iodo-4-hydroxybenzoate (IHB)] are reported at 2.0-2.2 A resolution with R-factors of 0. 0.159-0.179. The inhibitors bind in a narrow active site crevasse lined with residues that provide a microenvironment that closely matches the chemical characteristics of the inhibitors. This results in as little as 20% solvent-exposed surface area for the higher-affinity inhibitors (PHB, CHB, and FHB). In uncomplexed 3,4-PCD, the active site Fe3+ is bound at the bottom of the active site crevasse by four endogenous ligands and a solvent molecule (Wat827). The orientations of the endogenous ligands are relatively unperturbed in each inhibitor complex, but the inhibitors themselves bind to or near the iron in a range of positions, all of which perturb the position of Wat827. The three lowest-affinity inhibitors (MHP, PHP, and IHB) yield distorted trigonal bipyramidal iron coordination geometry in which the inhibitor C4-phenolate group displaces the solvent ligand. MHB binds within the active site, but neither its C3-OH group nor the solvent molecule binds to the iron. The C4-phenolate group of the three highest-affinity inhibitors (PHB, CHB, and FHB) coordinates the Fe3+ adjacent to Wat827, resulting in a shift in its position to yield a six-coordinate distorted octahedral geometry. The range of inhibitor orientations may mimic the mechanistically significant stages of substrate binding to 3, 4-PCD. The structure of the final substrate complex is reported in the following paper [Orville, A. M., Lipscomb, J. D., & Ohlendorf, D. H. (1997) Biochemistry 36, 10052-10066].

	~~==Function==~~		Structures of competitive inhibitor complexes of protocatechuate 3,4-dioxygenase: multiple exogenous ligand binding orientations within the active site.,Orville AM, Elango N, Lipscomb JD, Ohlendorf DH Biochemistry. 1997 Aug 19;36(33):10039-51. PMID:9254599<ref>PMID:9254599</ref>
	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/PCXA_PSEPU PCXA_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta~~-~~ketoadipate pathway~~. ~~[[http~~:/~~/www.uniprot.org/uniprot/PCXB_PSEPU PCXB_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3pcb]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_putida Pseudomonas putida]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:009254599</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Dioxygenase\|Dioxygenase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Protocatechuate 3,4-dioxygenase]]		[[Category: Protocatechuate 3,4-dioxygenase]]
	[[Category: Pseudomonas putida]]		[[Category: Pseudomonas putida]]
	[[Category: Elango, N.]]		[[Category: Elango, N]]
	[[Category: Lipscomb, J D.]]		[[Category: Lipscomb, J D]]
	[[Category: Ohlendorf, D H.]]		[[Category: Ohlendorf, D H]]
	[[Category: Orville, A M.]]		[[Category: Orville, A M]]
	[[Category: Dioxygenase]]		[[Category: Dioxygenase]]
	[[Category: Iron]]		[[Category: Iron]]

OCA: Protected "3pcb" [edit=sysop:move=sysop]

2013-05-02T08:36:38Z

Protected "3pcb" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:36, 2 May 2013
(No difference)

OCA at 08:36, 2 May 2013

2013-05-02T08:36:36Z

← Older revision		Revision as of 08:36, 2 May 2013
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	~~{{Seed}}~~
	~~[[Image:3pcb.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3pcb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3pcb\| PDB=3pcb \| SCENE= }}		{{STRUCTURE_3pcb\| PDB=3pcb \| SCENE= }}

	===STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE===		===STRUCTURE OF PROTOCATECHUATE 3,4-DIOXYGENASE COMPLEXED WITH 3-HYDROXYBENZOATE===
			{{ABSTRACT_PUBMED_9254599}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/PCXA_PSEPU PCXA_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway. [[http://www.uniprot.org/uniprot/PCXB_PSEPU PCXB_PSEPU]] Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9254599}}, adds~~ the ~~Publication Abstract to~~ the ~~page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 9254599 is~~ the ~~PubMed ID number~~.
	~~-->~~
	~~{{ABSTRACT_PUBMED_9254599}}~~

	==About this Structure==		==About this Structure==
	~~3PCB~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA].		[[3pcb]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~9254599~~</ref><references group="xtra"/>		<ref group="xtra">PMID:009254599</ref><references group="xtra"/><references/>
	[[Category: Protocatechuate 3,4-dioxygenase]]		[[Category: Protocatechuate 3,4-dioxygenase]]
	[[Category: Pseudomonas putida]]		[[Category: Pseudomonas putida]]
Line 35:		Line 22:
	[[Category: Nonheme]]		[[Category: Nonheme]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:55:11 2009''~~

OCA at 12:55, 17 February 2009

2009-02-17T12:55:13Z

← Older revision		Revision as of 12:55, 17 February 2009
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	==About this Structure==		==About this Structure==
	3PCB is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA].		3PCB is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCB OCA].

	==Reference==		==Reference==
	Structures of competitive inhibitor complexes of protocatechuate 3,4-dioxygenase: multiple exogenous ligand binding orientations within the active site., Orville AM, Elango N, Lipscomb JD, Ohlendorf DH, Biochemistry. 1997 Aug 19;36(33):10039-51. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9254599 9254599]~~		<ref group="xtra">PMID:9254599</ref><references group="xtra"/>
	~~[[Category: Protein complex]]~~
	[[Category: Protocatechuate 3,4-dioxygenase]]		[[Category: Protocatechuate 3,4-dioxygenase]]
	[[Category: Pseudomonas putida]]		[[Category: Pseudomonas putida]]
Line 37:		Line 36:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 12~~:59:~~46 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:55:11 2009''