3pgf - Revision history

OCA at 09:54, 6 September 2023

2023-09-06T09:54:16Z

← Older revision		Revision as of 09:54, 6 September 2023
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	<StructureSection load='3pgf' size='340' side='right'caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pgf' size='340' side='right'caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><~~/td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">malE, b4034, JW3994 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [https://pdbe.org/3pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [https://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [https://pdbe.org/3pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [https://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoli~~]]		[[Category: Escherichia coli K-12]]
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Duguid~~, E M~~]]		[[Category: Duguid EM]]
	[[Category: Kossiakoff~~, A A~~]]		[[Category: Kossiakoff AA]]
	[[Category: Sandstrom, A]]		[[Category: Sandstrom A]]
	~~[[Category: Antibody fragment]]~~
	~~[[Category: Engineered binding protein]]~~
	~~[[Category: Fab]]~~
	~~[[Category: Maltodextrin binding protein]]~~
	~~[[Category: Maltodextrin binding protein-de novo protein complex~~]]

OCA at 08:38, 25 May 2022

2022-05-25T08:38:41Z

← Older revision		Revision as of 08:38, 25 May 2022
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	==Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)==		==Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)==
	<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pgf' size='340' side='right'caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [~~http~~://pdbe.org/3pgf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [https://pdbe.org/3pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [https://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3pgf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pgf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Ecoli]]		[[Category: Ecoli]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Duguid, E M]]		[[Category: Duguid, E M]]
	[[Category: Kossiakoff, A A]]		[[Category: Kossiakoff, A A]]

OCA at 08:59, 8 November 2017

2017-11-08T08:59:20Z

← Older revision		Revision as of 08:59, 8 November 2017
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	<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://pdbe.org/3pgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://pdbe.org/3pgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 3pgf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pgf" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Maltose-binding protein\|Maltose-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Ecoli]]
			[[Category: Human]]
	[[Category: Duguid, E M]]		[[Category: Duguid, E M]]
	[[Category: Kossiakoff, A A]]		[[Category: Kossiakoff, A A]]

OCA at 08:52, 3 August 2017

2017-08-03T08:52:19Z

← Older revision		Revision as of 08:52, 3 August 2017
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	<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://pdbe.org/3pgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://pdbe.org/3pgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Ecoli]]~~
	~~[[Category: Human]]~~
	[[Category: Duguid, E M]]		[[Category: Duguid, E M]]
	[[Category: Kossiakoff, A A]]		[[Category: Kossiakoff, A A]]

OCA at 21:26, 5 August 2016

2016-08-05T21:26:20Z

← Older revision		Revision as of 21:26, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)==		==Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)==
	<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~]), DKFZp686P15220, ighg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), igk, IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), DKFZp686P15220, ighg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), igk, IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://pdbe.org/3pgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3pgf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli~~]]		[[Category: Ecoli]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Duguid, E M]]		[[Category: Duguid, E M]]
	[[Category: Kossiakoff, A A]]		[[Category: Kossiakoff, A A]]

OCA at 22:01, 25 December 2014

2014-12-25T22:01:42Z

← Older revision		Revision as of 22:01, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:18, 9 December 2014

2014-12-09T11:18:23Z

← Older revision		Revision as of 11:18, 9 December 2014
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	[[~~Image~~:~~3pgf~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)==
			<StructureSection load='3pgf' size='340' side='right' caption='[[3pgf]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGF FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), DKFZp686P15220, ighg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), igk, IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pgf RCSB], [http://www.ebi.ac.uk/pdbsum/3pgf PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We describe a phage display methodology for engineering synthetic antigen binders (sABs) that recognize either the apo or the ligand-bound conformation of maltose-binding protein (MBP). sABs that preferentially recognize the maltose-bound form of MBP act as positive allosteric effectors by substantially increasing the affinity for maltose. A crystal structure of a sAB bound to the closed form of MBP reveals the basis for this allosteric effect. We show that sABs that recognize the bound form of MBP can rescue the function of a binding-deficient mutant by restoring its natural affinity for maltose. Furthermore, the sABs can enhance maltose binding in vivo, as they provide a growth advantage to bacteria under low-maltose conditions. The results demonstrate that structure-specific sABs can be engineered to dynamically control ligand-binding affinities by modulating the transition between different conformations.

	~~{{STRUCTURE_3pgf\| PDB=3pgf \| SCENE= }}~~		Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.,Rizk SS, Paduch M, Heithaus JH, Duguid EM, Sandstrom A, Kossiakoff AA Nat Struct Mol Biol. 2011 Apr;18(4):437-42. Epub 2011 Mar 6. PMID:21378967<ref>PMID:21378967</ref>

	~~===Crystal structure~~ of ~~maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_21378967}}~~

	~~==About this Structure==~~
	~~[[3pgf]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli] and [http://en~~.~~wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].~~

	==See Also==		==See Also==
	*[[Maltose-binding protein\|Maltose-binding protein]]		*[[Maltose-binding protein\|Maltose-binding protein]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:021378967<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Duguid, E M.]]		[[Category: Duguid, E M]]
	[[Category: Kossiakoff, A A.]]		[[Category: Kossiakoff, A A]]
	[[Category: Sandstrom, A.]]		[[Category: Sandstrom, A]]
	[[Category: Antibody fragment]]		[[Category: Antibody fragment]]
	[[Category: Engineered binding protein]]		[[Category: Engineered binding protein]]

OCA at 22:10, 20 October 2012

2012-10-20T22:10:13Z

← Older revision		Revision as of 22:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3pgf]] is a 3 chain structure ~~of [[Maltose-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].		[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].

	==See Also==		==See Also==

OCA at 15:27, 27 July 2012

2012-07-27T15:27:15Z

← Older revision		Revision as of 15:27, 27 July 2012
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	[[Image:3pgf.png\|left\|200px]]		[[Image:3pgf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3pgf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3pgf\| PDB=3pgf \| SCENE= }}		{{STRUCTURE_3pgf\| PDB=3pgf \| SCENE= }}

	===Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)===		===Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21378967}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 21378967 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_21378967}}		{{ABSTRACT_PUBMED_21378967}}

	==About this Structure==		==About this Structure==
	[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].		[[3pgf]] is a 3 chain structure of [[Maltose-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].

			==See Also==
			*[[Maltose-binding protein\|Maltose-binding protein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~21378967~~</ref><references group="xtra"/>		<ref group="xtra">PMID:021378967</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 28:		Line 20:
	[[Category: Kossiakoff, A A.]]		[[Category: Kossiakoff, A A.]]
	[[Category: Sandstrom, A.]]		[[Category: Sandstrom, A.]]
			[[Category: Antibody fragment]]
			[[Category: Engineered binding protein]]
			[[Category: Fab]]
			[[Category: Maltodextrin binding protein]]
			[[Category: Maltodextrin binding protein-de novo protein complex]]

OCA at 09:55, 21 April 2011

2011-04-21T09:55:57Z

← Older revision		Revision as of 09:55, 21 April 2011
Line 1:		Line 1:
	[[Image:3pgf.~~jpg~~\|left\|200px]]		[[Image:3pgf.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)===		===Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_21378967}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 21378967 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_21378967}}

	==About this Structure==		==About this Structure==
	[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].		[[3pgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGF OCA].

			==Reference==
			<ref group="xtra">PMID:21378967</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]