3phb - Revision history

OCA at 10:40, 21 February 2024

2024-02-21T10:40:53Z

← Older revision		Revision as of 10:40, 21 February 2024
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	<StructureSection load='3phb' size='340' side='right'caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3phb' size='340' side='right'caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [https://pdbe.org/3phb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [https://www.ebi.ac.uk/pdbsum/3phb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [https://pdbe.org/3phb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [https://www.ebi.ac.uk/pdbsum/3phb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>		[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

	==See Also==		==See Also==
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Purine-nucleoside phosphorylase]]~~		[[Category: Almo SC]]
	[[Category: Almo~~, S C~~]]		[[Category: Cassera MB]]
	[[Category: Cassera~~, M B~~]]		[[Category: Ho M]]
	[[Category: Ho, M]]		[[Category: Murkin AS]]
	[[Category: Murkin~~, A S~~]]		[[Category: Schramm VL]]
	[[Category: Schramm~~, V L]]~~
	~~[[Category: Immucillin]]~~
	~~[[Category: Pnp]]~~
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 08:39, 25 May 2022

2022-05-25T08:39:22Z

← Older revision		Revision as of 08:39, 25 May 2022
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	==Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG==		==Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG==
	<StructureSection load='3phb' size='340' side='right' caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3phb' size='340' side='right'caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [~~http~~://pdbe.org/3phb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3phb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3phb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [https://pdbe.org/3phb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [https://www.ebi.ac.uk/pdbsum/3phb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[~~http~~://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>		[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

			==See Also==
			*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 08:59, 8 November 2017

2017-11-08T08:59:45Z

← Older revision		Revision as of 08:59, 8 November 2017
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>		[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

	~~==See Also==~~
	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:54, 11 August 2016

2016-08-11T07:54:34Z

← Older revision		Revision as of 07:54, 11 August 2016
Line 1:		Line 1:

	==Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG==		==Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG==
	<StructureSection load='3phb' size='340' side='right' caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3phb' size='340' side='right' caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [http://www.ebi.ac.uk/pdbsum/3phb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [http://pdbe.org/3phb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [http://www.ebi.ac.uk/pdbsum/3phb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3phb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 13:25, 6 November 2014

2014-11-06T13:25:32Z

← Older revision		Revision as of 13:25, 6 November 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3phb~~\| ~~PDB~~=3phb \| ~~SCENE~~= }}		==Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG==
	===~~Crystal Structure~~ of ~~human~~ purine nucleoside phosphorylase in ~~complex with DADMe-ImmG~~===		<StructureSection load='3phb' size='340' side='right' caption='[[3phb]], [[Resolution\|resolution]] 2.30Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PHB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM5:2-AMINO-7-{[(3R,4R)-3-HYDROXY-4-(HYDROXYMETHYL)PYRROLIDIN-1-YL]METHYL}-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>IM5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNP, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3phb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3phb RCSB], [http://www.ebi.ac.uk/pdbsum/3phb PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

	==~~Disease~~==		==See Also==
	[[~~http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine~~ nucleoside phosphorylase ~~deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179~~]]~~. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>~~		*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
			== References ==
	==~~Function~~==		<references/>
	[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</~~ref~~>		__TOC__
			</StructureSection>
	~~==About this Structure==~~
	[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA].

	~~==Reference==~~
	<~~references group="xtra"/><references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C]]
	[[Category: Cassera, M B.]]		[[Category: Cassera, M B]]
	[[Category: Ho, M.]]		[[Category: Ho, M]]
	[[Category: Murkin, A S.]]		[[Category: Murkin, A S]]
	[[Category: Schramm, V L.]]		[[Category: Schramm, V L]]
	[[Category: Immucillin]]		[[Category: Immucillin]]
	[[Category: Pnp]]		[[Category: Pnp]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:14, 24 March 2013

2013-03-24T10:14:41Z

← Older revision		Revision as of 10:14, 24 March 2013
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	~~[[Image:3phb.png\|left\|200px]]~~

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	{{STRUCTURE_3phb\| PDB=3phb \| SCENE= }}		{{STRUCTURE_3phb\| PDB=3phb \| SCENE= }}
			===Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG===

	===~~Crystal Structure~~ of ~~human~~ purine nucleoside phosphorylase in ~~complex with DADMe-ImmG===~~		==Disease==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

	==About this Structure==		==About this Structure==
	[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA].		[[3phb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHB OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]

OCA at 10:34, 14 December 2011

2011-12-14T10:34:09Z

← Older revision		Revision as of 10:34, 14 December 2011
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	[[Image:3phb.~~jpg~~\|left\|200px]]		[[Image:3phb.png\|left\|200px]]

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OCA at 11:45, 9 November 2011

2011-11-09T11:45:41Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3phb.jpg|left|200px]]
-The entry 3phb is ON HOLD  until Nov 09 2012
+<!--
-Authors: Ho, M., Cassera, M.B., Murkin, A.S., Almo, S.C., Schramm, V.L.
+===Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG===
-Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG

OCA at 05:22, 21 September 2011

2011-09-21T05:22:57Z

← Older revision		Revision as of 05:22, 21 September 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3phb is ON HOLD until ~~Paper Publication~~		The entry 3phb is ON HOLD until Nov 09 2012

	Authors: Ho, M., Cassera, M.B., Murkin, A.S., Almo, S.C., Schramm, V.L.		Authors: Ho, M., Cassera, M.B., Murkin, A.S., Almo, S.C., Schramm, V.L.

	Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG		Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG

OCA at 05:17, 16 February 2011

2011-02-16T05:17:28Z

← Older revision		Revision as of 05:17, 16 February 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3phb is ON HOLD until ~~sometime in the future~~		The entry 3phb is ON HOLD until Paper Publication

	Authors: Ho, M., Cassera, M.B., Murkin, A.S., Almo, S.C., Schramm, V.L.		Authors: Ho, M., Cassera, M.B., Murkin, A.S., Almo, S.C., Schramm, V.L.

	Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG		Description: Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG