3ppd - Revision history

OCA at 10:42, 21 February 2024

2024-02-21T10:42:29Z

← Older revision		Revision as of 10:42, 21 February 2024
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	<StructureSection load='3ppd' size='340' side='right'caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3ppd' size='340' side='right'caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [https://pdbe.org/3ppd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [https://www.ebi.ac.uk/pdbsum/3ppd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [https://pdbe.org/3ppd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [https://www.ebi.ac.uk/pdbsum/3ppd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>		[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils are associated with numerous pathologies as well as with normal cellular functions, and frequently form during protein denaturation. Inhibitors of pathological amyloid fibril formation could be useful in the development of therapeutics, provided that the inhibitors were specific enough to avoid interfering with normal processes. Here we show that computer-aided, structure-based design can yield highly specific peptide inhibitors of amyloid formation. Using known atomic structures of segments of amyloid fibrils as templates, we have designed and characterized an all-d-amino-acid inhibitor of the fibril formation of the tau protein associated with Alzheimer's disease, and a non-natural l-amino-acid inhibitor of an amyloid fibril that enhances sexual transmission of human immunodeficiency virus. Our results indicate that peptides from structure-based designs can disrupt the fibril formation of full-length proteins, including those, such as tau protein, that lack fully ordered native structures. Because the inhibiting peptides have been designed on structures of dual-beta-sheet 'steric zippers', the successful inhibition of amyloid fibril formation strengthens the hypothesis that amyloid spines contain steric zippers.

	Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.,Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Munch J, Baker D, Eisenberg D Nature. 2011 Jun 15. doi: 10.1038/nature10154. PMID:21677644<ref>PMID:21677644</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3ppd" style="background-color:#fffaf0;"></div~~>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg D]]
	[[Category: Sawaya~~, M R~~]]		[[Category: Sawaya MR]]
	[[Category: Zhao, A]]		[[Category: Zhao A]]
	~~[[Category: Amyloid fibril]]~~
	~~[[Category: Amyloid-like protofibril]]~~
	~~[[Category: Protein fibril~~]]

OCA at 08:49, 25 May 2022

2022-05-25T08:49:18Z

← Older revision		Revision as of 08:49, 25 May 2022
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	==GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection==		==GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection==
	<StructureSection load='3ppd' size='340' side='right' caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3ppd' size='340' side='right'caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PPD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [~~http~~://pdbe.org/3ppd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ppd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [https://pdbe.org/3ppd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [https://www.ebi.ac.uk/pdbsum/3ppd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>		[[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 19:14, 4 August 2016

2016-08-04T19:14:42Z

← Older revision		Revision as of 19:14, 4 August 2016
Line 1:		Line 1:

	==GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection==		==GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection==
	<StructureSection load='3ppd' size='340' side='right' caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3ppd' size='340' side='right' caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [http://www.ebi.ac.uk/pdbsum/3ppd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [http://pdbe.org/3ppd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [http://www.ebi.ac.uk/pdbsum/3ppd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ppd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:18, 25 December 2014

2014-12-25T12:18:57Z

← Older revision		Revision as of 12:18, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [http://www.ebi.ac.uk/pdbsum/3ppd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [http://www.ebi.ac.uk/pdbsum/3ppd PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:22, 19 December 2014

2014-12-19T10:22:33Z

← Older revision		Revision as of 10:22, 19 December 2014
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	~~{{STRUCTURE_3ppd\| PDB=3ppd \| SCENE= }}~~		==GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection==
	===GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection===		<StructureSection load='3ppd' size='340' side='right' caption='[[3ppd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_21677644}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3ppd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppd RCSB], [http://www.ebi.ac.uk/pdbsum/3ppd PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils are associated with numerous pathologies as well as with normal cellular functions, and frequently form during protein denaturation. Inhibitors of pathological amyloid fibril formation could be useful in the development of therapeutics, provided that the inhibitors were specific enough to avoid interfering with normal processes. Here we show that computer-aided, structure-based design can yield highly specific peptide inhibitors of amyloid formation. Using known atomic structures of segments of amyloid fibrils as templates, we have designed and characterized an all-d-amino-acid inhibitor of the fibril formation of the tau protein associated with Alzheimer's disease, and a non-natural l-amino-acid inhibitor of an amyloid fibril that enhances sexual transmission of human immunodeficiency virus. Our results indicate that peptides from structure-based designs can disrupt the fibril formation of full-length proteins, including those, such as tau protein, that lack fully ordered native structures. Because the inhibiting peptides have been designed on structures of dual-beta-sheet 'steric zippers', the successful inhibition of amyloid fibril formation strengthens the hypothesis that amyloid spines contain steric zippers.

	~~==Function==~~		Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.,Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Munch J, Baker D, Eisenberg D Nature. 2011 Jun 15. doi: 10.1038/nature10154. PMID:21677644<ref>PMID:21677644</ref>
	~~[[http://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A~~ non-~~specific tyrosine phosphatase that dephosphorylates a diverse number~~ of ~~substrates under acidic conditions (pH 4-6) including alkyl~~, ~~aryl~~, ~~and acyl orthophosphate monoesters and phosphorylated proteins~~. ~~Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma~~.~~<ref>PMID~~:~~15280042<~~/ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. ~~Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>~~PMID:~~18083097</ref> <ref>PMID:19403677</ref>~~ <ref>PMID:~~20498373~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3ppd]] is~~ a ~~1 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3PPD OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:021677644</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
	[[Category: Eisenberg, D.]]		</StructureSection>
	[[Category: Sawaya, M R.]]		[[Category: Eisenberg, D]]
	[[Category: Zhao, A.]]		[[Category: Sawaya, M R]]
			[[Category: Zhao, A]]
	[[Category: Amyloid fibril]]		[[Category: Amyloid fibril]]
	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA at 07:56, 16 May 2013

2013-05-16T07:56:21Z

← Older revision		Revision as of 07:56, 16 May 2013
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	~~[[Image:3ppd.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ppd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3ppd\| PDB=3ppd \| SCENE= }}		{{STRUCTURE_3ppd\| PDB=3ppd \| SCENE= }}

	===GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection===		===GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection===
			{{ABSTRACT_PUBMED_21677644}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21677644}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21677644 is~~ the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_21677644}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:021677644</ref><references group="xtra"/>		<ref group="xtra">PMID:021677644</ref><references group="xtra"/><references/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]

OCA at 08:02, 13 July 2011

2011-07-13T08:02:11Z

← Older revision		Revision as of 08:02, 13 July 2011
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	[[Image:3ppd.~~jpg~~\|left\|200px]]		[[Image:3ppd.png\|left\|200px]]

	<!--		<!--

OCA at 06:10, 29 June 2011

2011-06-29T06:10:20Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3ppd.jpg|left|200px]]
-The entry 3ppd is ON HOLD  until Paper Publication
+<!--
-Authors: Zhao, A., Sawaya, M.R., Eisenberg, D.
+===GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection===
-Description: GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection

OCA: Protected "3ppd" [edit=sysop:move=sysop]

2011-01-19T05:48:56Z

Protected "3ppd" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:48, 19 January 2011
(No difference)

OCA at 05:48, 19 January 2011

2011-01-19T05:48:55Z

← Older revision		Revision as of 05:48, 19 January 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3ppd is ON HOLD		The entry 3ppd is ON HOLD until Paper Publication

	Authors: Zhao, A., Sawaya, M.R., Eisenberg, D.		Authors: Zhao, A., Sawaya, M.R., Eisenberg, D.

	Description: GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection		Description: GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection

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