3ppf - Revision history

OCA at 09:58, 6 September 2023

2023-09-06T09:58:57Z

← Older revision		Revision as of 09:58, 6 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [https://pdbe.org/3ppf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [https://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [https://pdbe.org/3ppf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [https://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3ppf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ppf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Methionine synthase 3D structures\|Methionine synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:30, 30 September 2022

2022-09-30T04:30:51Z

← Older revision		Revision as of 04:30, 30 September 2022
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	<StructureSection load='3ppf' size='340' side='right'caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ppf' size='340' side='right'caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</div></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [https://pdbe.org/3ppf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [https://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [https://pdbe.org/3ppf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [https://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]		[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase~~]]		[[Category: Candida albicans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kavanagh, K]]		[[Category: Kavanagh K]]
	[[Category: Monzingo~~, A F~~]]		[[Category: Monzingo AF]]
	[[Category: Robertus~~, J D~~]]		[[Category: Robertus JD]]
	[[Category: Ubhi, D]]		[[Category: Ubhi D]]
	~~[[Category: Cobalamin-independent]]~~
	~~[[Category: Metalloproteinase]]~~
	~~[[Category: Methyltransferase]]~~
	~~[[Category: Surface entropy reduction]]~~
	~~[[Category: Transferase~~]]

OCA at 08:49, 25 May 2022

2022-05-25T08:49:28Z

← Older revision		Revision as of 08:49, 25 May 2022
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	==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc==		==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc==
	<StructureSection load='3ppf' size='340' side='right' caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ppf' size='340' side='right'caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [~~http~~://pdbe.org/3ppf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [https://pdbe.org/3ppf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [https://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]		[[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]		[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
			[[Category: Large Structures]]
	[[Category: Kavanagh, K]]		[[Category: Kavanagh, K]]
	[[Category: Monzingo, A F]]		[[Category: Monzingo, A F]]

OCA at 12:14, 5 August 2016

2016-08-05T12:14:37Z

← Older revision		Revision as of 12:14, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc==		==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc==
	<StructureSection load='3ppf' size='340' side='right' caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ppf' size='340' side='right' caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans Candida albicans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida ~~albicans~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [http://www.ebi.ac.uk/pdbsum/3ppf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [http://pdbe.org/3ppf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [http://www.ebi.ac.uk/pdbsum/3ppf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ppf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]		[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
	~~[[Category: Candida albicans]]~~
	[[Category: Kavanagh, K]]		[[Category: Kavanagh, K]]
	[[Category: Monzingo, A F]]		[[Category: Monzingo, A F]]

OCA at 22:56, 3 January 2015

2015-01-03T22:56:08Z

← Older revision		Revision as of 22:56, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [http://www.ebi.ac.uk/pdbsum/3ppf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [http://www.ebi.ac.uk/pdbsum/3ppf PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.,Ubhi D, Kavanagh KL, Monzingo AF, Robertus JD Arch Biochem Biophys. 2011 Sep 1;513(1):19-26. doi:, 10.1016/j.abb.2011.06.002. Epub 2011 Jun 12. PMID:21689631<ref>PMID:21689631</ref>		Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.,Ubhi D, Kavanagh KL, Monzingo AF, Robertus JD Arch Biochem Biophys. 2011 Sep 1;513(1):19-26. doi:, 10.1016/j.abb.2011.06.002. Epub 2011 Jun 12. PMID:21689631<ref>PMID:21689631</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]		[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Kavanagh, K.]]		[[Category: Kavanagh, K]]
	[[Category: Monzingo, A F.]]		[[Category: Monzingo, A F]]
	[[Category: Robertus, J D.]]		[[Category: Robertus, J D]]
	[[Category: Ubhi, D.]]		[[Category: Ubhi, D]]
	[[Category: Cobalamin-independent]]		[[Category: Cobalamin-independent]]
	[[Category: Metalloproteinase]]		[[Category: Metalloproteinase]]

OCA at 05:33, 4 June 2014

2014-06-04T05:33:09Z

← Older revision		Revision as of 05:33, 4 June 2014
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	[[~~Image~~:~~3ppf~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc==
			<StructureSection load='3ppf' size='340' side='right' caption='[[3ppf]], [[Resolution\|resolution]] 2.30Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3ppf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pph\|3pph]], [[3ppc\|3ppc]], [[3ppg\|3ppg]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppf RCSB], [http://www.ebi.ac.uk/pdbsum/3ppf PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Fungal methionine synthase, Met6p, transfers a methyl group from 5-methyl-tetrahydrofolate to homocysteine to generate methionine. The enzyme is essential to fungal growth and is a potential anti-fungal drug design target. We have characterized the enzyme from the pathogen Candida albicans but were unable to crystallize it in native form. We converted Lys103, Lys104, and Glu107 all to Tyr (Met6pY), Thr (Met6pT) and Ala (Met6pA). All variants showed wild-type kinetic activity and formed useful crystals, each with unique crystal packing. In each case the mutated residues participated in beneficial crystal contacts. We have solved the three structures at 2.0-2.8A resolution and analyzed crystal packing, active-site residues, and similarity to other known methionine synthase structures. C. albicans Met6p has a two domain structure with each of the domains having a (betaalpha)(8)-barrel fold. The barrels are arranged face-to-face and the active site is located in a cleft between the two domains. Met6p utilizes a zinc ion for catalysis that is bound in the C-terminal domain and ligated by four conserved residues: His657, Cys659, Glu679 and Cys739.

	~~<!--~~		Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.,Ubhi D, Kavanagh KL, Monzingo AF, Robertus JD Arch Biochem Biophys. 2011 Sep 1;513(1):19-26. doi:, 10.1016/j.abb.2011.06.002. Epub 2011 Jun 12. PMID:21689631<ref>PMID:21689631</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3ppf"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3ppf\| PDB=3ppf \| SCENE= }}~~

	~~===Crystal structure~~ of the ~~Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21689631}}, adds the Publication Abstract to the page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21689631 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_21689631}}~~

	~~==About this Structure==~~
	~~[[3ppf]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPF OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:021689631<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]		[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
	[[Category: Candida albicans]]		[[Category: Candida albicans]]

OCA at 09:38, 30 October 2011

2011-10-30T09:38:13Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3ppf.png|left|200px]]
-The entry 3ppf is ON HOLD  until Paper Publication
+<!--
-Authors: Ubhi, D., Kavanagh, K., Monzingo, A.F., Robertus, J.D.
+===Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc===
-Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc

OCA at 05:35, 29 June 2011

2011-06-29T05:35:23Z

← Older revision		Revision as of 05:35, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3ppf is ON HOLD		The entry 3ppf is ON HOLD until Paper Publication

	Authors: Ubhi, D., Kavanagh, K., Monzingo, A.F., Robertus, J.D.		Authors: Ubhi, D., Kavanagh, K., Monzingo, A.F., Robertus, J.D.

	Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc		Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc

OCA at 16:11, 22 June 2011

2011-06-22T16:11:53Z

← Older revision		Revision as of 16:11, 22 June 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3ppf is ON HOLD ~~until Paper Publication~~		The entry 3ppf is ON HOLD

	Authors: Ubhi, D., Kavanagh, K., Monzingo, A.F., Robertus, J.D.		Authors: Ubhi, D., Kavanagh, K., Monzingo, A.F., Robertus, J.D.

	Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc		Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine variant without zinc

OCA: Protected "3ppf" [edit=sysop:move=sysop]

2010-12-29T18:14:49Z

Protected "3ppf" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:14, 29 December 2010
(No difference)