3ps3 - Revision history

OCA at 10:43, 21 February 2024

2024-02-21T10:43:09Z

← Older revision		Revision as of 10:43, 21 February 2024
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	<StructureSection load='3ps3' size='340' side='right'caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ps3' size='340' side='right'caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoki Ecoki~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_IHE3034 Escherichia coli IHE3034]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ps2\|3ps2]], [[3ps1\|3ps1]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [https://pdbe.org/3ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [https://pdbe.org/3ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps3 ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[[https://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.

	Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.,Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ Bioorg Med Chem. 2011 Jan 15;19(2):852-60. Epub 2010 Dec 9. PMID:21194954<ref>PMID:21194954</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]		*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoki~~]]		[[Category: Escherichia coli IHE3034]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lee, C J]]		[[Category: Lee C-J]]
	[[Category: Zhou, P]]		[[Category: Zhou P]]
	~~[[Category: Acyl udp-glcnac]]~~
	~~[[Category: Antibiotic]]~~
	~~[[Category: Baab sandwich]]~~
	~~[[Category: Deacetylation]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-antibiotic complex]]~~
	~~[[Category: Hydroxamate]]~~
	~~[[Category: Lipid a biosynthesis]]~~
	~~[[Category: Lipid a synthesis]]~~
	~~[[Category: Lpc-053]]~~
	~~[[Category: Lpxc~~]]

OCA at 08:52, 25 May 2022

2022-05-25T08:52:32Z

← Older revision		Revision as of 08:52, 25 May 2022
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	==Crystal structure of the Escherichia Coli LPXC/LPC-053 complex==		==Crystal structure of the Escherichia Coli LPXC/LPC-053 complex==
	<StructureSection load='3ps3' size='340' side='right' caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ps3' size='340' side='right'caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoki Ecoki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoki Ecoki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ps2\|3ps2]], [[3ps1\|3ps1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ps2\|3ps2]], [[3ps1\|3ps1]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [~~http~~://pdbe.org/3ps3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ps3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [https://pdbe.org/3ps3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ps3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]		[[https://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Ecoki]]		[[Category: Ecoki]]
			[[Category: Large Structures]]
	[[Category: Lee, C J]]		[[Category: Lee, C J]]
	[[Category: Zhou, P]]		[[Category: Zhou, P]]

OCA at 09:06, 8 November 2017

2017-11-08T09:06:22Z

← Older revision		Revision as of 09:06, 8 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:33, 5 August 2016

2016-08-05T13:33:12Z

← Older revision		Revision as of 13:33, 5 August 2016
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	==Crystal structure of the Escherichia Coli LPXC/LPC-053 complex==		==Crystal structure of the Escherichia Coli LPXC/LPC-053 complex==
	<StructureSection load='3ps3' size='340' side='right' caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ps3' size='340' side='right' caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_ihe3034 Escherichia coli ihe3034~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoki Ecoki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ps2\|3ps2]], [[3ps1\|3ps1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ps2\|3ps2]], [[3ps1\|3ps1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ~~Escherichia coli IHE3034~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ps3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [http://pdbe.org/3ps3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ps3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ps3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli ihe3034~~]]		[[Category: Ecoki]]
	[[Category: Lee, C J]]		[[Category: Lee, C J]]
	[[Category: Zhou, P]]		[[Category: Zhou, P]]

OCA at 02:54, 25 December 2014

2014-12-25T02:54:22Z

← Older revision		Revision as of 02:54, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3ps3\| PDB=3ps3 \| SCENE= }}~~		==Crystal structure of the Escherichia Coli LPXC/LPC-053 complex==
	===Crystal structure of the Escherichia Coli LPXC/LPC-053 complex===		<StructureSection load='3ps3' size='340' side='right' caption='[[3ps3]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~{{ABSTRACT_PUBMED_21194954}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3ps3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_ihe3034 Escherichia coli ihe3034]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PS3 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=L53:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3S)-3-HYDROXY-1-NITROSO-1-OXOBUTAN-2-YL]BENZAMIDE'>L53</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ps2\|3ps2]], [[3ps1\|3ps1]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 Escherichia coli IHE3034])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ps3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ps3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ps3 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.

	~~==Function==~~		Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.,Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ Bioorg Med Chem. 2011 Jan 15;19(2):852-60. Epub 2010 Dec 9. PMID:21194954<ref>PMID:21194954</ref>
	~~[[http://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A~~, ~~a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane~~ of the ~~cell~~ (~~By similarity~~).~~[HAMAP-Rule~~:~~MF_00388][SAAS~~:~~SAAS004463_004_013136]~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3ps3]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_ihe3034 Escherichia coli ihe3034]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3PS3 OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:021194954</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Escherichia coli ihe3034]]		[[Category: Escherichia coli ihe3034]]
	[[Category: Lee, C J]]		[[Category: Lee, C J]]
	[[Category: Zhou, P.]]		[[Category: Zhou, P]]
	[[Category: Acyl udp-glcnac]]		[[Category: Acyl udp-glcnac]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 08:34, 8 May 2013

2013-05-08T08:34:10Z

@@ Line 1: / Line 1: @@
 {{STRUCTURE_3ps3|  PDB=3ps3  |  SCENE=  }}
 ===Crystal structure of the Escherichia Coli LPXC/LPC-053 complex===
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:21194954</ref><references group="xtra"/>
+<ref group="xtra">PMID:021194954</ref><references group="xtra"/><references/>
 [[Category: Escherichia coli ihe3034]]
 [[Category: Lee, C J]]
 [[Category: Zhou, P.]]

OCA at 05:34, 9 February 2011

2011-02-09T05:34:09Z

← Older revision		Revision as of 05:34, 9 February 2011
Line 1:		Line 1:
	[[Image:3ps3.~~jpg~~\|left\|200px]]		[[Image:3ps3.png\|left\|200px]]

	<!--		<!--

OCA: Protected "3ps3" [edit=sysop:move=sysop]

2011-01-19T06:28:18Z

Protected "3ps3" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:28, 19 January 2011
(No difference)

OCA at 06:28, 19 January 2011

2011-01-19T06:28:17Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3ps3.jpg|left|200px]]
-The entry 3ps3 is ON HOLD
+<!--
-Authors: Lee, C.-J, Zhou, P.
+===Crystal structure of the Escherichia Coli LPXC/LPC-053 complex===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:25:04 2010''
+<!--

OCA at 05:12, 15 December 2010

2010-12-15T05:12:44Z

← Older revision		Revision as of 05:12, 15 December 2010
Line 5:		Line 5:
	Authors: Lee, C.-J, Zhou, P.		Authors: Lee, C.-J, Zhou, P.

	Description: ~~CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI~~ LPXC/LPC-053 ~~COMPLEX~~		Description: Crystal structure of the Escherichia Coli LPXC/LPC-053 complex

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~8 11~~:33:29 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:25:04 2010''