3qo7 - Revision history

OCA at 11:52, 14 March 2024

2024-03-14T11:52:39Z

← Older revision		Revision as of 11:52, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [https://pdbe.org/3qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [https://pdbe.org/3qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).		[https://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	In a restricted group of opportunistic fungal pathogens the universal leucine CUG codon is translated both as serine (97%) and leucine (3%), challenging the concept that translational ambiguity has a negative impact in living organisms. To elucidate the molecular mechanisms underlying the in vivo tolerance to a nonconserved genetic code alteration, we have undertaken an extensive structural analysis of proteins containing CUG-encoded residues and solved the crystal structures of the two natural isoforms of Candida albicans seryl-tRNA synthetase. We show that codon reassignment resulted in a nonrandom genome-wide CUG redistribution tailored to minimize protein misfolding events induced by the large-scale leucine-to-serine replacement within the CTG clade. Leucine or serine incorporation at the CUG position in C. albicans seryl-tRNA synthetase induces only local structural changes and, although both isoforms display tRNA serylation activity, the leucine-containing isoform is more active. Similarly, codon ambiguity is predicted to shape the function of C. albicans proteins containing CUG-encoded residues in functionally relevant positions, some of which have a key role in signaling cascades associated with morphological changes and pathogenesis. This study provides a first detailed analysis on natural reassignment of codon identity, unveiling a highly dynamic evolutionary pattern of thousands of fungal CUG codons to confer an optimized balance between protein structural robustness and functional plasticity.

	Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.,Rocha R, Pereira PJ, Santos MA, Macedo-Ribeiro S Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825144<ref>PMID:21825144</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3qo7" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]		*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:30, 30 September 2022

2022-09-30T04:30:25Z

← Older revision		Revision as of 04:30, 30 September 2022
Line 3:		Line 3:
	<StructureSection load='3qo7' size='340' side='right'caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3qo7' size='340' side='right'caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11006_[[monilia_stellatoidea]] Atcc 11006 [[monilia stellatoidea]]~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Monilia stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [https://pdbe.org/3qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [https://pdbe.org/3qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).		[https://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Candida albicans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Serine--tRNA ligase]]~~		[[Category: Macedo-Ribeiro S]]
	[[Category: Macedo-Ribeiro, S]]		[[Category: Pereira PJB]]
	[[Category: Pereira~~, P J.B~~]]		[[Category: Rocha R]]
	[[Category: Rocha, R]]		[[Category: Santos MA]]
	[[Category: Santos~~, M A]]~~
	~~[[Category: Amino acid biosynthesis]]~~
	~~[[Category: Aminoacyl-trna synthetase]]~~
	~~[[Category: Class-ii aminoacyl-trna synthetase family]]~~
	~~[[Category: Codon ambiguity]]~~
	~~[[Category: Ctg-clade]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Pathogen]]~~
	~~[[Category: Serine]]~~
	~~[[Category: Trna]]~~
	~~[[Category: Type-1 seryl-trna synthetase subfamily~~]]

OCA at 06:16, 8 June 2022

2022-06-08T06:16:53Z

← Older revision		Revision as of 06:16, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of the seryl-tRNA synthetase from Candida albicans==		==Crystal structure of the seryl-tRNA synthetase from Candida albicans==
	<StructureSection load='3qo7' size='340' side='right' caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3qo7' size='340' side='right'caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11006_[[~~candida_stellatoidea~~]] Atcc 11006 [[~~candida~~ stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11006_[[monilia_stellatoidea]] Atcc 11006 [[monilia stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[~~Candida~~ stellatoidea]]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Monilia stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [~~http~~://pdbe.org/3qo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [https://pdbe.org/3qo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).		[[https://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3qo7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qo7" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Serine--tRNA ligase]]		[[Category: Serine--tRNA ligase]]
	[[Category: Macedo-Ribeiro, S]]		[[Category: Macedo-Ribeiro, S]]

OCA at 22:37, 4 August 2016

2016-08-04T22:37:10Z

← Older revision		Revision as of 22:37, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the seryl-tRNA synthetase from Candida albicans==		==Crystal structure of the seryl-tRNA synthetase from Candida albicans==
	<StructureSection load='3qo7' size='340' side='right' caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3qo7' size='340' side='right' caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://pdbe.org/3qo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3qo7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:18, 24 December 2014

2014-12-24T20:18:03Z

← Older revision		Revision as of 20:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SYSC_CANAL SYSC_CANAL]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Serine--tRNA ligase]]		[[Category: Serine--tRNA ligase]]
	[[Category: Macedo-Ribeiro, S.]]		[[Category: Macedo-Ribeiro, S]]
	[[Category: Pereira, P J.B.]]		[[Category: Pereira, P J.B]]
	[[Category: Rocha, R.]]		[[Category: Rocha, R]]
	[[Category: Santos, M A.]]		[[Category: Santos, M A]]
	[[Category: Amino acid biosynthesis]]		[[Category: Amino acid biosynthesis]]
	[[Category: Aminoacyl-trna synthetase]]		[[Category: Aminoacyl-trna synthetase]]

OCA at 07:11, 10 September 2014

2014-09-10T07:11:06Z

← Older revision		Revision as of 07:11, 10 September 2014
Line 2:		Line 2:
	<StructureSection load='3qo7' size='340' side='right' caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3qo7' size='340' side='right' caption='[[3qo7]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans Candida albicans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QO7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qne\|3qne]], [[3qo5\|3qo5]], [[3qo8\|3qo8]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida ~~albicans~~])</td></tr>		<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SES1, CaO19.7901 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine--tRNA_ligase Serine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.11 6.1.1.11] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qo7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qo7 PDBsum]</span></td></tr>
Line 15:		Line 15:
	Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.,Rocha R, Pereira PJ, Santos MA, Macedo-Ribeiro S Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825144<ref>PMID:21825144</ref>		Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.,Rocha R, Pereira PJ, Santos MA, Macedo-Ribeiro S Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825144<ref>PMID:21825144</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Candida albicans]]~~
	[[Category: Serine--tRNA ligase]]		[[Category: Serine--tRNA ligase]]
	[[Category: Macedo-Ribeiro, S.]]		[[Category: Macedo-Ribeiro, S.]]

OCA at 05:21, 4 June 2014

2014-06-04T05:21:19Z

@@ Line 1: / Line 1: @@
-[[Image:3qo7.png|left|200px]]
+==Crystal structure of the seryl-tRNA synthetase from Candida albicans==
-<!--
+Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.,Rocha R, Pereira PJ, Santos MA, Macedo-Ribeiro S Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825144<ref>PMID:21825144</ref>
-===Crystal structure of the seryl-tRNA synthetase from Candida albicans===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21825144}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21825144 is the PubMed ID number.
+</StructureSection>
 [[Category: Candida albicans]]
 [[Category: Serine--tRNA ligase]]

OCA at 04:55, 24 August 2011

2011-08-24T04:55:05Z

← Older revision		Revision as of 04:55, 24 August 2011
Line 1:		Line 1:
	[[Image:3qo7.~~jpg~~\|left\|200px]]		[[Image:3qo7.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of the seryl-tRNA synthetase from Candida albicans===		===Crystal structure of the seryl-tRNA synthetase from Candida albicans===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_21825144}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 21825144 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_21825144}}

	==About this Structure==		==About this Structure==
	[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA].		[[3qo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO7 OCA].

			==Reference==
			<ref group="xtra">PMID:021825144</ref><references group="xtra"/>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Serine--tRNA ligase]]		[[Category: Serine--tRNA ligase]]

OCA at 08:59, 3 August 2011

2011-08-03T08:59:06Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3qo7.jpg|left|200px]]
-The entry 3qo7 is ON HOLD  until Paper Publication
+<!--
-Authors: Rocha, R., Santos, M.A., Pereira, P.J.B., Macedo-Ribeiro, S.
+===Crystal structure of the seryl-tRNA synthetase from Candida albicans===
-Description: Crystal structure of the seryl-tRNA synthetase from Candida albicans

OCA at 09:39, 23 February 2011

2011-02-23T09:39:23Z

← Older revision		Revision as of 09:39, 23 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3qo7 is ON HOLD		The entry 3qo7 is ON HOLD until Paper Publication

	Authors: Rocha, R., Santos, M.A., Pereira, P.J.B., Macedo-Ribeiro, S.		Authors: Rocha, R., Santos, M.A., Pereira, P.J.B., Macedo-Ribeiro, S.

	Description: Crystal structure of the seryl-tRNA synthetase from Candida albicans		Description: Crystal structure of the seryl-tRNA synthetase from Candida albicans