3qvb - Revision history

OCA at 12:00, 14 March 2024

2024-03-14T12:00:02Z

← Older revision		Revision as of 12:00, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qvb' size='340' side='right'caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3qvb' size='340' side='right'caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3q4s\|3q4s]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">GYG, GYG1~~ (~~[https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]~~)~~</td~~></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [https://pdbe.org/3qvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [https://www.ebi.ac.uk/pdbsum/3qvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [https://pdbe.org/3qvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [https://www.ebi.ac.uk/pdbsum/3qvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.		[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-residue "lid" segment covering the active site. The rearranged lid guides the nascent maltosaccharide chain into the active site in either an intra- or intersubunit mode dependent upon chain length and steric factors and positions the donor and acceptor sugar groups for catalysis. The Thr83Met mutation, which causes glycogen storage disease XV, is conformationally locked in the ground state and catalytically inactive. Our data highlight the conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism.

	Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.,Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW Proc Natl Acad Sci U S A. 2011 Dec 12. PMID:22160680<ref>PMID:22160680</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3qvb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Glycogenin\|Glycogenin]]		*[[Glycogenin\|Glycogenin]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Glycogenin glucosyltransferase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Arrowsmith CH]]
	[[Category: Bountra, C]]		[[Category: Bountra C]]
	[[Category: Chaikuad, A]]		[[Category: Chaikuad A]]
	~~[[Category: Delft, F von~~]]		[[Category: Edwards AM]]
	[[Category: Edwards~~, A M~~]]		[[Category: Froese DS]]
	[[Category: Froese~~, D S~~]]		[[Category: Krysztofinska E]]
	[[Category: Krysztofinska, E]]		[[Category: Oppermann U]]
	[[Category: Oppermann, U]]		[[Category: Weigelt J]]
	~~[[Category: Structural genomic~~]]		[[Category: Yue WW]]
	[[Category: Weigelt, J]]		[[Category: Von Delft F]]
	[[Category: Yue~~, W W~~]]
	[[Category: ~~Glycogen biosynthesis]]~~
	~~[[Category: Glycosylation]]~~
	~~[[Category: Glycosyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 05:37, 15 June 2022

2022-06-15T05:37:52Z

← Older revision		Revision as of 05:37, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP==		==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP==
	<StructureSection load='3qvb' size='340' side='right' caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3qvb' size='340' side='right'caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q4s\|3q4s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q4s\|3q4s]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [~~http~~://pdbe.org/3qvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [https://pdbe.org/3qvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [https://www.ebi.ac.uk/pdbsum/3qvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.		[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 32:		Line 32:
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 11:25, 10 December 2016

2016-12-10T11:25:42Z

← Older revision		Revision as of 11:25, 10 December 2016
Line 1:		Line 1:

	==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP==		==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP==
	<StructureSection load='3qvb' size='340' side='right' caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3qvb' size='340' side='right' caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q4s\|3q4s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q4s\|3q4s]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [http://www.ebi.ac.uk/pdbsum/3qvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [http://pdbe.org/3qvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [http://www.ebi.ac.uk/pdbsum/3qvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvb ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[http://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3qvb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 12:00, 9 December 2014

2014-12-09T12:00:50Z

← Older revision		Revision as of 12:00, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~3qvb~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP==
			<StructureSection load='3qvb' size='340' side='right' caption='[[3qvb]], [[Resolution\|resolution]] 2.26Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3qvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q4s\|3q4s]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvb RCSB], [http://www.ebi.ac.uk/pdbsum/3qvb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-residue "lid" segment covering the active site. The rearranged lid guides the nascent maltosaccharide chain into the active site in either an intra- or intersubunit mode dependent upon chain length and steric factors and positions the donor and acceptor sugar groups for catalysis. The Thr83Met mutation, which causes glycogen storage disease XV, is conformationally locked in the ground state and catalytically inactive. Our data highlight the conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism.

	~~{{STRUCTURE_3qvb\| PDB=3qvb \| SCENE= }}~~		Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.,Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW Proc Natl Acad Sci U S A. 2011 Dec 12. PMID:22160680<ref>PMID:22160680</ref>

	~~===Crystal Structure~~ of ~~Human Glycogenin-1 (GYG1) complexed with manganese and UDP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22160680}}~~

	~~==About this Structure==~~
	~~[[3qvb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3QVB OCA].~~

	==See Also==		==See Also==
	*[[Glycogenin\|Glycogenin]]		*[[Glycogenin\|Glycogenin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:022160680<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Chaikuad, A.]]		[[Category: Chaikuad, A]]
	[[Category: Delft, F von.]]		[[Category: Delft, F von]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Froese, D S.]]		[[Category: Froese, D S]]
	[[Category: Krysztofinska, E.]]		[[Category: Krysztofinska, E]]
	[[Category: Oppermann, U.]]		[[Category: Oppermann, U]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Yue, W W.]]		[[Category: Yue, W W]]
	[[Category: Glycogen biosynthesis]]		[[Category: Glycogen biosynthesis]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:39, 20 October 2012

2012-10-20T07:39:16Z

← Older revision		Revision as of 07:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3qvb]] is a 1 chain structure ~~of [[Glycogenin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA].		[[3qvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA].

	==See Also==		==See Also==

OCA at 17:00, 25 July 2012

2012-07-25T17:00:59Z

← Older revision		Revision as of 17:00, 25 July 2012
Line 1:		Line 1:
	[[Image:3qvb.png\|left\|200px]]		[[Image:3qvb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3qvb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3qvb\| PDB=3qvb \| SCENE= }}		{{STRUCTURE_3qvb\| PDB=3qvb \| SCENE= }}

	===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP===		===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22160680}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 22160680 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_22160680}}		{{ABSTRACT_PUBMED_22160680}}

Line 22:		Line 11:

	==See Also==		==See Also==
	*[[Glycogenin]]		*[[Glycogenin\|Glycogenin]]

	==Reference==		==Reference==

OCA at 06:04, 28 December 2011

2011-12-28T06:04:44Z

← Older revision		Revision as of 06:04, 28 December 2011
Line 11:		Line 11:
	===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP===		===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22160680}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22160680 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22160680}}

	==About this Structure==		==About this Structure==
Line 17:		Line 23:
	==See Also==		==See Also==
	*[[Glycogenin]]		*[[Glycogenin]]

			==Reference==
			<ref group="xtra">PMID:022160680</ref><references group="xtra"/>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 10:37, 14 December 2011

2011-12-14T10:37:07Z

← Older revision		Revision as of 10:37, 14 December 2011
Line 1:		Line 1:
	[[Image:3qvb.~~jpg~~\|left\|200px]]		[[Image:3qvb.png\|left\|200px]]

	<!--		<!--
Line 13:		Line 13:

	==About this Structure==		==About this Structure==
	[[3qvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA].		[[3qvb]] is a 1 chain structure of [[Glycogenin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVB OCA].

			==See Also==
			*[[Glycogenin]]
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 27:		Line 30:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Yue, W W.]]		[[Category: Yue, W W.]]
			[[Category: Glycogen biosynthesis]]
			[[Category: Glycosylation]]
			[[Category: Glycosyltransferase]]
			[[Category: Structural genomic]]
			[[Category: Structural genomics consortium]]
			[[Category: Transferase]]

OCA at 07:22, 23 March 2011

2011-03-23T07:22:03Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3qvb.jpg|left|200px]]
-The entry 3qvb is ON HOLD
+<!--
-Authors: Chaikuad, A., Froese, D.S., Yue, W.W., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
+===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP===
-Description: Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in an open form

OCA: Protected "3qvb" [edit=sysop:move=sysop]

2011-03-09T06:07:49Z

Protected "3qvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:07, 9 March 2011
(No difference)