3rd5 - Revision history

OCA at 10:53, 21 February 2024

2024-02-21T10:53:47Z

← Older revision		Revision as of 10:53, 21 February 2024
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	<StructureSection load='3rd5' size='340' side='right'caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rd5' size='340' side='right'caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_paratuberculosis"_(bergey_et_al~~.~~_1923)_krasil'nikov_1941 "bacillus~~ paratuberculosis~~" (bergey et al. 1923) krasil'nikov 1941~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-~~1~~-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MAP_0980c ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1770 "Bacillus paratuberculosis"~~ (~~Bergey et al. 1923~~) ~~Krasil~~'~~nikov 1941])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [https://pdbe.org/3rd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [https://pdbe.org/3rd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd5 ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed~~ ==		[https://www.uniprot.org/uniprot/Q741V7_MYCPA Q741V7_MYCPA]
	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:~~25613812<ref>PMID:25613812<~~/~~ref>~~

	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 3rd5" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references~~/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Structural genomic]]~~		[[Category: Mycobacterium avium subsp. paratuberculosis]]
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Ssgcid~~]]

OCA at 05:58, 15 June 2022

2022-06-15T05:58:35Z

← Older revision		Revision as of 05:58, 15 June 2022
Line 1:		Line 1:

	==Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis==		==Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis==
	<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rd5' size='340' side='right'caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [~~http~~://pdbe.org/3rd5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rd5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [https://pdbe.org/3rd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]

OCA at 18:44, 1 February 2017

2017-02-01T18:44:37Z

← Older revision		Revision as of 18:44, 1 February 2017
Line 1:		Line 1:

	==Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis==		==Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis==
	<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [http://pdbe.org/3rd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3rd5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:57, 22 April 2015

2015-04-22T06:57:29Z

← Older revision		Revision as of 06:57, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_avium_subsp~~.~~_paratuberculosis Mycobacterium avium subsp~~. ~~paratuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 ~~Mycobacterium avium subsp~~. ~~paratuberculosis~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd5 PDBsum]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

			Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Mycobacterium avium subsp. paratuberculosis]]~~
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]

OCA at 10:24, 19 December 2014

2014-12-19T10:24:25Z

← Older revision		Revision as of 10:24, 19 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3rd5\| PDB=3rd5 \| SCENE= }}~~		==Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis==
	===Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis===		<StructureSection load='3rd5' size='340' side='right' caption='[[3rd5]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
	==~~About this Structure~~==		<table><tr><td colspan='2'>[[3rd5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD5 FirstGlance]. <br>
	[[3rd5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA].		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0980c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 Mycobacterium avium subsp. paratuberculosis])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd5 PDBsum]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
	[[Category: Mycobacterium avium subsp. paratuberculosis]]		[[Category: Mycobacterium avium subsp. paratuberculosis]]
	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]		[[Category: Structural genomic]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	~~[[Category: Seattle structural genomics center for infectious disease]]~~
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	~~[[Category: Structural genomic]]~~

OCA at 07:58, 16 May 2013

2013-05-16T07:58:14Z

@@ Line 1: / Line 1: @@
 {{STRUCTURE_3rd5|  PDB=3rd5  |  SCENE=  }}
 ===Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis===
 ==About this Structure==
@@ Line 16: / Line 6: @@
 [[Category: Mycobacterium avium subsp. paratuberculosis]]
 [[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 04:24, 8 June 2011

2011-06-08T04:24:59Z

← Older revision		Revision as of 04:24, 8 June 2011
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	[[Image:3rd5.~~jpg~~\|left\|200px]]		[[Image:3rd5.png\|left\|200px]]

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OCA at 10:54, 21 April 2011

2011-04-21T10:54:36Z

← Older revision		Revision as of 10:54, 21 April 2011
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	~~'''Unreleased structure'''~~		[[Image:3rd5.jpg\|left\|200px]]

	The ~~entry~~ 3rd5 ~~is ON HOLD~~		<!--
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			{{STRUCTURE_3rd5\| PDB=3rd5 \| SCENE= }}

	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~		===Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis===

	~~Description~~: ~~Crystal structure of a putative uncharacterized protein~~ from Mycobacterium ~~Paratuberculosis~~
			==About this Structure==
			[[3rd5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD5 OCA].
			[[Category: Mycobacterium avium subsp. paratuberculosis]]
			[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 04:58, 13 April 2011

2011-04-13T04:58:40Z

← Older revision		Revision as of 04:58, 13 April 2011
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	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: ~~CRYSTAL STRUCTURE OF A PUTATIVE UNCHARACTERIZED PROTEIN FROM MYCOBACTERIUM PARATUBERCULOSIS~~		Description: Crystal structure of a putative uncharacterized protein from Mycobacterium Paratuberculosis

OCA: Protected "3rd5" [edit=sysop:move=sysop]

2011-04-06T08:44:19Z

Protected "3rd5" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:44, 6 April 2011
(No difference)