3rd7 - Revision history

OCA at 12:19, 14 March 2024

2024-03-14T12:19:12Z

← Older revision		Revision as of 12:19, 14 March 2024
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	<StructureSection load='3rd7' size='340' side='right'caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3rd7' size='340' side='right'caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myca1 Myca1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium_104 Mycobacterium avium 104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MAV_2540 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [https://pdbe.org/3rd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [https://pdbe.org/3rd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd7 ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style~~=~~"background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed ==~~		[https://www.uniprot.org/uniprot/A0A0H2ZY91_MYCA1 A0A0H2ZY91_MYCA1]
	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~

	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 3rd7" style="background-color:#fffaf0;"><~~/~~div>~~

	==See Also==		==See Also==
	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]		*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Myca1]]~~		[[Category: Mycobacterium avium 104]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Acyl-coa thioesterase]]~~
	~~[[Category: Hydrolase]]~~
	[[Category: Mycobacterium avium]]
	~~[[Category: Ssgcid~~]]

OCA at 05:58, 15 June 2022

2022-06-15T05:58:38Z

← Older revision		Revision as of 05:58, 15 June 2022
Line 1:		Line 1:

	==Crystal structure of acyl-coa thioesterase from mycobacterium avium==		==Crystal structure of acyl-coa thioesterase from mycobacterium avium==
	<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3rd7' size='340' side='right'caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [~~http~~://pdbe.org/3rd7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rd7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [https://pdbe.org/3rd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 3rd7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rd7" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Myca1]]		[[Category: Myca1]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:41, 1 February 2017

2017-02-01T18:41:24Z

← Older revision		Revision as of 18:41, 1 February 2017
Line 1:		Line 1:

	==Crystal structure of acyl-coa thioesterase from mycobacterium avium==		==Crystal structure of acyl-coa thioesterase from mycobacterium avium==
	<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [http://pdbe.org/3rd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3rd7" style="background-color:#fffaf0;"></div>
	==~~See Also==~~
	*[[Thioesterase\|Thioesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:47, 22 April 2015

2015-04-22T06:47:27Z

← Older revision		Revision as of 06:47, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_avium Mycobacterium avium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca1 Myca1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1764 Mycobacterium avium~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243243 MYCA1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd7 PDBsum]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

			Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Thioesterase\|Thioesterase]]		*[[Thioesterase\|Thioesterase]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium avium~~]]		[[Category: Myca1]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acyl-coa thioesterase]]		[[Category: Acyl-coa thioesterase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
			[[Category: Mycobacterium avium]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]

OCA at 10:55, 9 December 2014

2014-12-09T10:55:54Z

← Older revision		Revision as of 10:55, 9 December 2014
Line 1:		Line 1:
	~~[[Image:3rd7.png\|left\|200px]]~~		==Crystal structure of acyl-coa thioesterase from mycobacterium avium==
			<StructureSection load='3rd7' size='340' side='right' caption='[[3rd7]], [[Resolution\|resolution]] 1.95Å' scene=''>
	~~{{STRUCTURE_3rd7\| PDB=3rd7 \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD7 FirstGlance]. <br>
	===Crystal structure of acyl-coa thioesterase from mycobacterium avium===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAV_2540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1764 Mycobacterium avium])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd7 PDBsum]</span></td></tr>
	==~~About this Structure~~==		</table>
	[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].

	==See Also==		==See Also==
	*[[Thioesterase\|Thioesterase]]		*[[Thioesterase\|Thioesterase]]
			__TOC__
			</StructureSection>
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]		[[Category: Structural genomic]]
	[[Category: Acyl-coa thioesterase]]		[[Category: Acyl-coa thioesterase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	~~[[Category: Mycobacterium avium]]~~
	~~[[Category: Seattle structural genomics center for infectious disease]]~~
	[[Category: Ssgcid]]		[[Category: Ssgcid]]

OCA at 21:33, 20 October 2012

2012-10-20T21:33:22Z

← Older revision		Revision as of 21:33, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3rd7]] is a 2 chain structure ~~of [[Thioesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].		[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].

	==See Also==		==See Also==

OCA at 13:36, 27 July 2012

2012-07-27T13:36:06Z

← Older revision		Revision as of 13:36, 27 July 2012
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	[[Image:3rd7.~~jpg~~\|left\|200px]]		[[Image:3rd7.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3rd7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3rd7\| PDB=3rd7 \| SCENE= }}		{{STRUCTURE_3rd7\| PDB=3rd7 \| SCENE= }}

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	==About this Structure==		==About this Structure==
	[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].		[[3rd7]] is a 2 chain structure of [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].

			==See Also==
			*[[Thioesterase\|Thioesterase]]
	[[Category: Mycobacterium avium]]		[[Category: Mycobacterium avium]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
			[[Category: Acyl-coa thioesterase]]
			[[Category: Hydrolase]]
			[[Category: Mycobacterium avium]]
			[[Category: Seattle structural genomics center for infectious disease]]
			[[Category: Ssgcid]]

OCA at 05:23, 8 June 2011

2011-06-08T05:23:52Z

← Older revision		Revision as of 05:23, 8 June 2011
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	~~'''Unreleased structure'''~~		[[Image:3rd7.jpg\|left\|200px]]

	The ~~entry~~ 3rd7 ~~is ON HOLD~~		<!--
			The line below this paragraph, containing "STRUCTURE_3rd7", creates the "Structure Box" on the page.
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			{{STRUCTURE_3rd7\| PDB=3rd7 \| SCENE= }}

	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~		===Crystal structure of acyl-coa thioesterase from mycobacterium avium===

	~~Description~~: ~~Crystal structure of acyl~~-~~coa thioesterase from mycobacterium~~ avium
			==About this Structure==
			[[3rd7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD7 OCA].
			[[Category: Mycobacterium avium]]
			[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 04:58, 13 April 2011

2011-04-13T04:58:41Z

← Older revision		Revision as of 04:58, 13 April 2011
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	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: ~~CRYSTAL STRUCTURE OF ACYL~~-~~COA THIOESTERASE FROM MYCOBACTERIUM AVIUM~~		Description: Crystal structure of acyl-coa thioesterase from mycobacterium avium

OCA: Protected "3rd7" [edit=sysop:move=sysop]

2011-04-06T08:44:23Z

Protected "3rd7" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:44, 6 April 2011
(No difference)