3rdt - Revision history

OCA at 09:38, 30 October 2024

2024-10-30T09:38:08Z

← Older revision		Revision as of 09:38, 30 October 2024
Line 8:		Line 8:
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~HB2A_MOUSE HB2A_MOUSE~~]		[https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual alphabetaTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here we have identified a role for the differential pairing of particular V gene segments in creating TCRs that recognized MHC class II ligands exclusively, or cross-reacted with classical and nonclassical MHC class I ligands. Biophysical and structural experiments indicated that TCR specificity for MHC ligands is not driven by germline-encoded pairwise interactions. Rather, identical TCRbeta chains can have altered peptide-MHC (pMHC) binding modes when paired with different TCRalpha chains. The ability of TCR chain pairing to modify how V region residues interact with pMHC helps to explain how the same V genes are used to create TCRs specific for unique MHC ligands.

			A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 3rdt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
	*[[MHC II 3D structures\|MHC II 3D structures]]		*[[MHC II 3D structures\|MHC II 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:19, 14 March 2024

2024-03-14T12:19:57Z

← Older revision		Revision as of 12:19, 14 March 2024
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	<StructureSection load='3rdt' size='340' side='right'caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rdt' size='340' side='right'caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~] and [https://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">H2-Aa ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [https://pdbe.org/3rdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [https://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [https://pdbe.org/3rdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [https://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed~~ ==		[https://www.uniprot.org/uniprot/HB2A_MOUSE HB2A_MOUSE]
	A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual alphabetaTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here we have identified a role for the differential pairing of particular V gene segments in creating TCRs that recognized MHC class II ligands exclusively, or cross-reacted with classical and nonclassical MHC class I ligands. Biophysical and structural experiments indicated that TCR specificity for MHC ligands is not driven by germline-encoded pairwise interactions. Rather, identical TCRbeta chains can have altered peptide-MHC (pMHC) binding modes when paired with different TCRalpha chains. ~~The ability of TCR chain pairing to modify how V region residues interact with pMHC helps to explain how the same V genes are used to create TCRs specific for unique MHC ligands~~.

	A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>		==See Also==
			*[[MHC 3D structures\|MHC 3D structures]]
	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~		*[[MHC II 3D structures\|MHC II 3D structures]]
	~~</div>~~
	~~<div class~~=~~"pdbe-citations 3rdt" style~~=~~"background-color:#fffaf0;"></div>~~
	~~== References~~ ==
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Synthetic construct ~~sequences~~]]		[[Category: Synthetic construct]]
	[[Category: Huseby~~, E S~~]]		[[Category: Huseby ES]]
	[[Category: Stern~~, L J~~]]		[[Category: Stern LJ]]
	[[Category: Trenh, P]]		[[Category: Trenh P]]
	~~[[Category: Ig-like domain]]~~
	~~[[Category: Immune receptor]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Mhc]]~~
	~~[[Category: Tcr~~]]

OCA at 05:59, 15 June 2022

2022-06-15T05:59:17Z

← Older revision		Revision as of 05:59, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==		==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==
	<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rdt' size='340' side='right'caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [~~http~~://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [https://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [~~http~~://pdbe.org/3rdt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [https://pdbe.org/3rdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [https://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]

OCA at 21:58, 15 November 2017

2017-11-15T21:58:26Z

← Older revision		Revision as of 21:58, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10090 LK3 transgenic mice~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://pdbe.org/3rdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://pdbe.org/3rdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
			[[Category: Synthetic construct sequences]]
	[[Category: Huseby, E S]]		[[Category: Huseby, E S]]
	[[Category: Stern, L J]]		[[Category: Stern, L J]]

OCA at 19:37, 11 August 2016

2016-08-11T19:37:09Z

← Older revision		Revision as of 19:37, 11 August 2016
Line 1:		Line 1:

	==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==		==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==
	<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice~~] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://pdbe.org/3rdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3rdt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	~~[[Category: Mus musculus]]~~
	[[Category: Huseby, E S]]		[[Category: Huseby, E S]]
	[[Category: Stern, L J]]		[[Category: Stern, L J]]

OCA at 09:12, 4 January 2015

2015-01-04T09:12:53Z

← Older revision		Revision as of 09:12, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>		A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Huseby, E S.]]		[[Category: Huseby, E S]]
	[[Category: Stern, L J.]]		[[Category: Stern, L J]]
	[[Category: Trenh, P.]]		[[Category: Trenh, P]]
	[[Category: Ig-like domain]]		[[Category: Ig-like domain]]
	[[Category: Immune receptor]]		[[Category: Immune receptor]]

OCA at 04:43, 5 June 2014

2014-06-05T04:43:10Z

← Older revision		Revision as of 04:43, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~3rdt~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==
			<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c60\|3c60]], [[3c6l\|3c6l]], [[3c5z\|3c5z]], [[1lnu\|1lnu]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual alphabetaTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here we have identified a role for the differential pairing of particular V gene segments in creating TCRs that recognized MHC class II ligands exclusively, or cross-reacted with classical and nonclassical MHC class I ligands. Biophysical and structural experiments indicated that TCR specificity for MHC ligands is not driven by germline-encoded pairwise interactions. Rather, identical TCRbeta chains can have altered peptide-MHC (pMHC) binding modes when paired with different TCRalpha chains. The ability of TCR chain pairing to modify how V region residues interact with pMHC helps to explain how the same V genes are used to create TCRs specific for unique MHC ligands.

	~~<!--~~		A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3rdt"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3rdt\| PDB=3rdt \| SCENE= }}~~

	~~===Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab~~/~~3k peptide===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22101158}}, adds~~ the ~~Publication Abstract to the page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22101158 is the PubMed ID number~~.		</StructureSection>
	-->		[[Category: Lk3 transgenic mice]]
	~~{{ABSTRACT_PUBMED_22101158}}~~

	~~==About this Structure==~~
	~~[[3rdt]] is a 4 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mus_musculus,_synthetic_construct Mus musculus, synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA].

	==~~Reference~~==
	<~~ref group="xtra">PMID:022101158<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Mus musculus, synthetic construct]]~~
	[[Category: Huseby, E S.]]		[[Category: Huseby, E S.]]
	[[Category: Stern, L J.]]		[[Category: Stern, L J.]]

OCA at 05:49, 8 February 2012

2012-02-08T05:49:07Z

← Older revision		Revision as of 05:49, 8 February 2012
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	[[Image:3rdt.~~jpg~~\|left\|200px]]		[[Image:3rdt.png\|left\|200px]]

	<!--		<!--

OCA at 08:00, 7 December 2011

2011-12-07T08:00:46Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3rdt.jpg|left|200px]]
-The entry 3rdt is ON HOLD
+<!--
-Authors: Trenh, P., Huseby, E.S., Stern, L.J.
+===Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide===
-Description: Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide

OCA at 05:44, 30 November 2011

2011-11-30T05:44:55Z

← Older revision		Revision as of 05:44, 30 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rdt is ON HOLD ~~until Paper Publication~~		The entry 3rdt is ON HOLD

	Authors: Trenh, P., Huseby, E.S., Stern, L.J.		Authors: Trenh, P., Huseby, E.S., Stern, L.J.

	Description: Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide		Description: Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide