3rez - Revision history

OCA at 06:08, 17 October 2024

2024-10-17T06:08:19Z

← Older revision		Revision as of 06:08, 17 October 2024
Line 3:		Line 3:
	<StructureSection load='3rez' size='340' side='right'caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3rez' size='340' side='right'caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rfe\|3rfe]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [https://pdbe.org/3rez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [https://www.ebi.ac.uk/pdbsum/3rez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rez ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [https://pdbe.org/3rez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [https://www.ebi.ac.uk/pdbsum/3rez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rez ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Bernard-Soulier syndrome;22q11.2 deletion syndrome;Fetal and neonatal alloimmune thrombocytopenia. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN] Bernard-Soulier syndrome;22q11.2 deletion syndrome;Fetal and neonatal alloimmune thrombocytopenia. The disease is caused by mutations affecting the gene represented in this entry.[https://www.uniprot.org/uniprot/GPIX_HUMAN GPIX_HUMAN] Bernard-Soulier syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.		[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN] Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.[https://www.uniprot.org/uniprot/GPIX_HUMAN GPIX_HUMAN] The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Carr~~, K H~~]]		[[Category: Carr KH]]
	[[Category: Emsley, J]]		[[Category: Emsley J]]
	[[Category: Li, R]]		[[Category: Li R]]
	[[Category: McEwan~~, P A~~]]		[[Category: McEwan PA]]
	[[Category: Mo, X]]		[[Category: Mo X]]
	[[Category: Yang, W]]		[[Category: Yang W]]
	[[Category: Zheng, X]]		[[Category: Zheng X]]
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Gp1bb and gpix]]~~
	~~[[Category: Platelet surface receptor~~]]

OCA at 06:00, 15 June 2022

2022-06-15T06:00:43Z

← Older revision		Revision as of 06:00, 15 June 2022
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	==glycoprotein GPIb variant==		==glycoprotein GPIb variant==
	<StructureSection load='3rez' size='340' side='right' caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3rez' size='340' side='right'caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3REZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rfe\|3rfe]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [~~http~~://pdbe.org/3rez PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rez PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rez ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [https://pdbe.org/3rez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [https://www.ebi.ac.uk/pdbsum/3rez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rez ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Bernard-Soulier syndrome;22q11.2 deletion syndrome;Fetal and neonatal alloimmune thrombocytopenia. The disease is caused by mutations affecting the gene represented in this entry.		[[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Bernard-Soulier syndrome;22q11.2 deletion syndrome;Fetal and neonatal alloimmune thrombocytopenia. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.		[[https://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Carr, K H]]		[[Category: Carr, K H]]
	[[Category: Emsley, J]]		[[Category: Emsley, J]]

OCA at 16:54, 11 August 2016

2016-08-11T16:54:11Z

← Older revision		Revision as of 16:54, 11 August 2016
Line 1:		Line 1:

	==glycoprotein GPIb variant==		==glycoprotein GPIb variant==
	<StructureSection load='3rez' size='340' side='right' caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3rez' size='340' side='right' caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [http://www.ebi.ac.uk/pdbsum/3rez PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [http://pdbe.org/3rez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [http://www.ebi.ac.uk/pdbsum/3rez PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rez ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Bernard-Soulier syndrome;22q11.2 deletion syndrome;Fetal and neonatal alloimmune thrombocytopenia. The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[http://www.uniprot.org/uniprot/GP1BB_HUMAN GP1BB_HUMAN]] Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3rez" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Carr, K H]]		[[Category: Carr, K H]]
	[[Category: Emsley, J]]		[[Category: Emsley, J]]

OCA at 10:20, 4 January 2015

2015-01-04T10:20:48Z

← Older revision		Revision as of 10:20, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REZ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [http://www.ebi.ac.uk/pdbsum/3rez PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [http://www.ebi.ac.uk/pdbsum/3rez PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera.,McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J Blood. 2011 Nov 10;118(19):5292-301. Epub 2011 Sep 8. PMID:21908432<ref>PMID:21908432</ref>		Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera.,McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J Blood. 2011 Nov 10;118(19):5292-301. Epub 2011 Sep 8. PMID:21908432<ref>PMID:21908432</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carr, K H.]]		[[Category: Carr, K H]]
	[[Category: Emsley, J.]]		[[Category: Emsley, J]]
	[[Category: Li, R.]]		[[Category: Li, R]]
	[[Category: McEwan, P A.]]		[[Category: McEwan, P A]]
	[[Category: Mo, X.]]		[[Category: Mo, X]]
	[[Category: Yang, W.]]		[[Category: Yang, W]]
	[[Category: Zheng, X.]]		[[Category: Zheng, X]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Gp1bb and gpix]]		[[Category: Gp1bb and gpix]]
	[[Category: Platelet surface receptor]]		[[Category: Platelet surface receptor]]

OCA at 04:44, 5 June 2014

2014-06-05T04:44:28Z

← Older revision		Revision as of 04:44, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~3rez~~.~~jpg~~\|~~left~~\|~~200px~~]]		==glycoprotein GPIb variant==
			<StructureSection load='3rez' size='340' side='right' caption='[[3rez]], [[Resolution\|resolution]] 2.35Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3rez]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REZ FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rfe\|3rfe]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP1BB, GP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rez RCSB], [http://www.ebi.ac.uk/pdbsum/3rez PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Platelet GPIb-IX receptor complex has 3 subunits GPIbalpha, GPIbbeta, and GPIX, which assemble with a ratio of 1:2:1. Dysfunction in surface expression of the complex leads to Bernard-Soulier syndrome. We have crystallized the GPIbbeta ectodomain (GPIbbeta(E)) and determined the structure to show a single leucine-rich repeat with N- and C-terminal disulphide-bonded capping regions. The structure of a chimera of GPIbbeta(E) and 3 loops (a,b,c) taken from the GPIX ectodomain sequence was also determined. The chimera (GPIbbeta(Eabc)), but not GPIbbeta(E), forms a tetramer in the crystal, showing a quaternary interface between GPIbbeta and GPIX. Central to this interface is residue Tyr106 from GPIbbeta, which inserts into a pocket generated by 2 loops (b,c) from GPIX. Mutagenesis studies confirmed this interface as a valid representation of interactions between GPIbbeta and GPIX in the full-length complex. Eight GPIbbeta missense mutations identified from patients with Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Two mutations, A108P and P74R, were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX surface expression. The close structural proximity of these mutations to Tyr106 and the GPIbbeta(E) interface with GPIX indicates they disrupt the quaternary organization of the GPIb-IX complex.

	<!--		Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera.,McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J Blood. 2011 Nov 10;118(19):5292-301. Epub 2011 Sep 8. PMID:21908432<ref>PMID:21908432</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3rez"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter~~ (~~which sets the initial scene displayed when the page is loaded~~),
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3rez\| PDB=3rez \| SCENE= }}~~

	~~===glycoprotein GPIb variant===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21908432}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21908432 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_21908432}}~~

	~~==About this Structure==~~
	~~[[3rez]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REZ OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:021908432<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carr, K H.]]		[[Category: Carr, K H.]]

OCA at 06:41, 15 February 2012

2012-02-15T06:41:56Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3rez.jpg|left|200px]]
-The entry 3rez is ON HOLD  until Paper Publication
+<!--
-Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.
+===glycoprotein GPIb variant===
-Description: glycoprotein GPIb variant

OCA at 06:15, 31 August 2011

2011-08-31T06:15:39Z

← Older revision		Revision as of 06:15, 31 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rez is ON HOLD		The entry 3rez is ON HOLD until Paper Publication

	Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.		Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.

	Description: glycoprotein GPIb variant		Description: glycoprotein GPIb variant

OCA at 05:26, 10 August 2011

2011-08-10T05:26:07Z

← Older revision		Revision as of 05:26, 10 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rez is ON HOLD ~~until Paper Publication~~		The entry 3rez is ON HOLD

	Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.		Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.

	Description: glycoprotein GPIb variant		Description: glycoprotein GPIb variant

OCA at 05:38, 29 June 2011

2011-06-29T05:38:36Z

← Older revision		Revision as of 05:38, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rez is ON HOLD		The entry 3rez is ON HOLD until Paper Publication

	Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.		Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.

	Description: glycoprotein GPIb variant		Description: glycoprotein GPIb variant

OCA at 05:20, 1 June 2011

2011-06-01T05:20:48Z

← Older revision		Revision as of 05:20, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rez is ON HOLD ~~until sometime in the future~~		The entry 3rez is ON HOLD

	Authors: McEwan, P. A., Yang, W., Carr, K. H., Mo. X., Zheng, X., Li, R., Emsley, J.		Authors: McEwan, P.A., Yang, W., Carr, K.H., Mo, X., Zheng, X., Li, R., Emsley, J.

	Description: glycoprotein GPIb variant		Description: glycoprotein GPIb variant