3rt0 - Revision history

OCA at 17:19, 1 November 2023

2023-11-01T17:19:08Z

← Older revision		Revision as of 17:19, 1 November 2023
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	<StructureSection load='3rt0' size='340' side='right'caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='3rt0' size='340' side='right'caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.113Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em~~;~~'>[[3rt2\|3rt2]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HAB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~3702 ARATH]), PYL10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [https://pdbe.org/3rt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [https://pdbe.org/3rt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[https://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).		[https://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath~~]]		[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Phosphoprotein phosphatase]]~~		[[Category: Hao Q]]
	[[Category: Hao, Q]]		[[Category: Li W]]
	[[Category: Li, W]]		[[Category: Wang J]]
	[[Category: Wang, J]]		[[Category: Wang L]]
	[[Category: Wang, L]]		[[Category: Yan C]]
	[[Category: Yan, C]]		[[Category: Yan N]]
	[[Category: Yan, N]]		[[Category: Yin P]]
	[[Category: Yin, P]]
	~~[[Category: Apo-pyl10 inhibits hab1 dephosphorylation activity]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Pyl10-hab1 binary complex~~]]

OCA at 10:24, 22 June 2022

2022-06-22T10:24:17Z

← Older revision		Revision as of 10:24, 22 June 2022
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	==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==		==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==
	<StructureSection load='3rt0' size='340' side='right' caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='3rt0' size='340' side='right'caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rt2\|3rt2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rt2\|3rt2]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAB1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), PYL10 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), PYL10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [~~http~~://pdbe.org/3rt0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [https://pdbe.org/3rt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[~~http~~://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).		[[https://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[https://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[~~ABA-regulated Protein Phosphatase 2C\|ABA-regulated Protein Phosphatase 2C]]~~		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
	*[[PYR/PYL/RCAR family of ABA receptors\|~~PYR/PYL/RCAR family of ABA receptors~~]]		*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
			[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 15:42, 4 August 2016

2016-08-04T15:42:33Z

← Older revision		Revision as of 15:42, 4 August 2016
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	==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==		==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==
	<StructureSection load='3rt0' size='340' side='right' caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='3rt0' size='340' side='right' caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rt2\|3rt2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rt2\|3rt2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~]), PYL10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), PYL10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [http://pdbe.org/3rt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3rt0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 16:35, 24 December 2014

2014-12-24T16:35:08Z

← Older revision		Revision as of 16:35, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt0 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[http://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:13, 19 December 2014

2014-12-19T10:13:18Z

← Older revision		Revision as of 10:13, 19 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3rt0\| PDB=3rt0 \| SCENE= }}~~		==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==
	===Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)===		<StructureSection load='3rt0' size='340' side='right' caption='[[3rt0]], [[Resolution\|resolution]] 2.11Å' scene=''>
	~~{{ABSTRACT_PUBMED_21658606}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rt2\|3rt2]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), PYL10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt0 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			PYR1/PYL/RCAR proteins (PYLs) are confirmed abscisic acid (ABA) receptors, which inhibit protein phosphatase 2C (PP2C) upon binding to ABA. Arabidopsis thaliana has 14 PYLs, yet their functional distinction remains unclear. Here, we report systematic biochemical characterization of PYLs. A subclass of PYLs, represented by PYL10, inhibited PP2C in the absence of any ligand. Crystal structures of PYL10, both in the free form and in the HAB1 (PP2C)-bound state, revealed the structural basis for its constitutive activity. Structural-guided biochemical analyses revealed that ABA-independent inhibition of PP2C requires the PYLs to exist in a monomeric state. In addition, the residues guarding the entrance to the ligand-binding pocket of these PYLs should be bulky and hydrophobic. Based on these principles, we were able to generate monomeric PYL2 variants that gained constitutive inhibitory effect on PP2Cs. These findings provide an important framework for understanding the complex regulation of ABA signaling by PYL proteins.

	~~==Function==~~		The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins.,Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu JZ, Wang J, Yan SF, Yan N Mol Cell. 2011 Jun 10;42(5):662-72. PMID:21658606<ref>PMID:21658606</ref>
	~~[[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor~~ of ~~the abscisic acid (~~ABA~~) signaling pathway that regulates numerous ABA responses~~, ~~such as stomatal closure~~, ~~seed germination and inhibition of vegetative growth~~. ~~Confers enhanced sensitivity to drought~~.~~<ref>~~PMID:~~14731256</ref>~~ <ref>PMID:~~16876791~~</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[http://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3rt0]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA].~~		</div>

	==See Also==		==See Also==
			*[[ABA-regulated Protein Phosphatase 2C\|ABA-regulated Protein Phosphatase 2C]]
			*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	*[[Protein phosphatase\|Protein phosphatase]]		*[[Protein phosphatase\|Protein phosphatase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:021658606</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q]]
	[[Category: Li, W.]]		[[Category: Li, W]]
	[[Category: Wang, J.]]		[[Category: Wang, J]]
	[[Category: Wang, L.]]		[[Category: Wang, L]]
	[[Category: Yan, C.]]		[[Category: Yan, C]]
	[[Category: Yan, N.]]		[[Category: Yan, N]]
	[[Category: Yin, P.]]		[[Category: Yin, P]]
	[[Category: Apo-pyl10 inhibits hab1 dephosphorylation activity]]		[[Category: Apo-pyl10 inhibits hab1 dephosphorylation activity]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Pyl10-hab1 binary complex]]		[[Category: Pyl10-hab1 binary complex]]

OCA at 07:47, 16 May 2013

2013-05-16T07:47:14Z

← Older revision		Revision as of 07:47, 16 May 2013
Line 1:		Line 1:
	~~[[Image:3rt0.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3rt0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3rt0\| PDB=3rt0 \| SCENE= }}		{{STRUCTURE_3rt0\| PDB=3rt0 \| SCENE= }}

	===Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)===		===Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)===
			{{ABSTRACT_PUBMED_21658606}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> [[http://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21658606}}~~, ~~adds the Publication Abstract~~ to ~~the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21658606 is~~ the ~~PubMed ID number~~.
	~~-->~~
	~~{{ABSTRACT_PUBMED_21658606}}~~

	==About this Structure==		==About this Structure==
	[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA].		[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA].

			==See Also==
			*[[Protein phosphatase\|Protein phosphatase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:021658606</ref><references group="xtra"/>		<ref group="xtra">PMID:021658606</ref><references group="xtra"/><references/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]

OCA at 16:38, 22 June 2011

2011-06-22T16:38:05Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3rt0.jpg|left|200px]]
-The entry 3rt0 is ON HOLD  until Paper Publication
+<!--
-Authors: Hao, Q., Yin, P., Li, W., Wang, L., Yan, C., Wang, J., Yan, N.
+===Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)===
-Description: Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)

OCA at 05:09, 25 May 2011

2011-05-25T05:09:31Z

← Older revision		Revision as of 05:09, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rt0 is ON HOLD		The entry 3rt0 is ON HOLD until Paper Publication

	Authors: Hao, Q., Yin, P., Li, W., Wang, L., Yan, C., Wang, J., Yan, N.		Authors: Hao, Q., Yin, P., Li, W., Wang, L., Yan, C., Wang, J., Yan, N.

	Description: ~~The molecular basis~~ of ~~ABA~~-~~independent inhibition~~ of ~~PP2Cs by a subclass of PYL proteins~~		Description: Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)

OCA at 05:15, 18 May 2011

2011-05-18T05:15:23Z

← Older revision		Revision as of 05:15, 18 May 2011
Line 3:		Line 3:
	The entry 3rt0 is ON HOLD		The entry 3rt0 is ON HOLD

	Authors: Qi Hao, ~~Ping~~ Yin, ~~Wenqi~~ Li, Li Wang, ~~Chuangye~~ Yan, ~~Jiawei~~ Wang, ~~Nieng~~ Yan		Authors: Hao, Q., Yin, P., Li, W., Wang, L., Yan, C., Wang, J., Yan, N.

	Description: The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins		Description: The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins

OCA: Protected "3rt0" [edit=sysop:move=sysop]

2011-05-12T04:23:44Z

Protected "3rt0" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:23, 12 May 2011
(No difference)