3rt3 - Revision history

OCA at 17:19, 1 November 2023

2023-11-01T17:19:12Z

← Older revision		Revision as of 17:19, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3rt3' size='340' side='right'caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rt3' size='340' side='right'caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.006Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ISG15, G1P2, UCRP ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [https://pdbe.org/3rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [https://pdbe.org/3rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN]] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> [[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>		[https://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li, L]]		[[Category: Li L]]
	[[Category: Wang~~, X Q]]~~		[[Category: Wang XQ]]
	~~[[Category: Antiviral protein-viral protein complex]]~~
	~~[[Category: Isgylation]]~~
	~~[[Category: Ubiquitin-like domain~~]]

OCA at 10:24, 22 June 2022

2022-06-22T10:24:19Z

← Older revision		Revision as of 10:24, 22 June 2022
Line 1:		Line 1:

	==Complex of influenza virus protein with host anti-viral factor==		==Complex of influenza virus protein with host anti-viral factor==
	<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rt3' size='340' side='right'caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [~~http~~://pdbe.org/3rt3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [https://pdbe.org/3rt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN]] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> [[~~http~~://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>		[[https://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN]] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> [[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]

OCA at 00:49, 16 November 2017

2017-11-16T00:49:09Z

← Older revision		Revision as of 00:49, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human Human~~] and [http://en.wikipedia.org/wiki/~~Inble Inble~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN~~]), NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=107412 INBLE~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://pdbe.org/3rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://pdbe.org/3rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	~~[[Category: Inble]]~~
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]

OCA at 18:21, 4 August 2016

2016-08-04T18:21:27Z

← Older revision		Revision as of 18:21, 4 August 2016
Line 1:		Line 1:

	==Complex of influenza virus protein with host anti-viral factor==		==Complex of influenza virus protein with host anti-viral factor==
	<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Influenza_b_virus Influenza b virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Inble Inble]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~11520 Influenza B virus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=107412 INBLE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://pdbe.org/3rt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: ~~Influenza b virus~~]]		[[Category: Inble]]
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]

OCA at 11:51, 25 December 2014

2014-12-25T11:51:25Z

← Older revision		Revision as of 11:51, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN]] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> [[http://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:32, 19 December 2014

2014-12-19T10:32:24Z

← Older revision		Revision as of 10:32, 19 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3rt3\| PDB=3rt3 \| SCENE= }}~~		==Complex of influenza virus protein with host anti-viral factor==
	===Complex of influenza virus protein with host anti-viral factor===		<StructureSection load='3rt3' size='340' side='right' caption='[[3rt3]], [[Resolution\|resolution]] 2.01Å' scene=''>
			== Structural highlights ==
	==~~Function~~==		<table><tr><td colspan='2'>[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT3 FirstGlance]. <br>
	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~ISG15_HUMAN ISG15_HUMAN~~]] ~~Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation~~. ~~Its enzymatic pathway~~ is ~~partially distinct~~ from ~~that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes~~. ~~ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme~~. ~~Targets include STAT1, SERPINA3G~~/~~SPI2A, JAK1, MAPK3~~/~~ERK1, PLCG1, EIF2AK2~~/~~PKR, MX1~~/~~MxA, and RIG-1. Deconjugated by USP18~~/~~UBP43~~. ~~Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors~~. ~~May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments~~. ~~May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell~~-~~to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages~~. ~~Seems to display antiviral activity during viral infections~~.<~~ref~~>~~PMID:1373138~~</~~ref~~> ~~<ref>PMID:7526157~~</~~ref~~> <~~ref~~>~~PMID:8550581~~<~~/ref~~> <~~ref~~>~~PMID~~:~~2005397~~</~~ref~~> <~~ref~~>~~PMID:16254333~~<~~/ref~~> <~~ref~~>~~PMID:16009940~~</~~ref~~> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</~~ref> <ref~~>~~PMID:7526157~~</~~ref~~> <~~ref~~>~~PMID:8550581~~<~~/ref~~> <~~ref~~>~~PMID~~:~~2005397~~</~~ref> <ref~~>~~PMID:16254333~~</~~ref~~> <~~ref~~>~~PMID:16009940</ref> [~~[http://www.~~uniprot~~.~~org~~/~~uniprot~~/~~NS1_INBLE NS1_INBLE~~]~~] Binds and inhibits the ubiquitin-like protein G1P2~~/~~ISG15, which is an early antiviral protein~~. ~~Inhibits IRF-3 nuclear translocation and activation~~. ~~Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2~~/~~PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2~~/~~PKR~~. ~~Also binds poly(A~~) ~~and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.~~<~~ref~~>~~PMID:15479798~~</~~ref~~>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ISG15, G1P2, UCRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11520 Influenza B virus])</td></tr>
	==~~About this Structure~~==		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt3 PDBsum]</span></td></tr>
	[[3rt3]~~] is a 2 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Homo_sapiens Homo sapiens~~] ~~and~~ [http://en.~~wikipedia~~.org/~~wiki~~/~~Influenza_b_virus Influenza b virus~~]~~. Full crystallographic information is available from~~ [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort?id=3RT3 OCA~~].		</table>
			__TOC__
	~~==Reference==~~		</StructureSection>
	<~~references group="xtra"~~/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Influenza b virus]]		[[Category: Influenza b virus]]
	[[Category: Li, L.]]		[[Category: Li, L]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]
	[[Category: Antiviral protein-viral protein complex]]		[[Category: Antiviral protein-viral protein complex]]
	[[Category: Isgylation]]		[[Category: Isgylation]]
	[[Category: Ubiquitin-like domain]]		[[Category: Ubiquitin-like domain]]

OCA at 08:06, 16 May 2013

2013-05-16T08:06:52Z

← Older revision		Revision as of 08:06, 16 May 2013
Line 1:		Line 1:
	~~[[Image:3rt3.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3rt3", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3rt3\| PDB=3rt3 \| SCENE= }}		{{STRUCTURE_3rt3\| PDB=3rt3 \| SCENE= }}

	===Complex of influenza virus protein with host anti-viral factor===		===Complex of influenza virus protein with host anti-viral factor===

			==Function==
			[[http://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN]] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> [[http://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>

	==About this Structure==		==About this Structure==
	[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA].		[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Influenza b virus]]		[[Category: Influenza b virus]]

OCA at 07:50, 13 July 2011

2011-07-13T07:50:38Z

← Older revision		Revision as of 07:50, 13 July 2011
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		[[Image:3rt3.jpg\|left\|200px]]

	The ~~entry~~ 3rt3 ~~is ON HOLD~~ ~~until Paper Publication~~		<!--
			The line below this paragraph, containing "STRUCTURE_3rt3", creates the "Structure Box" on the page.
			You may change the PDB parameter (which sets the PDB file loaded into the applet)
			or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
			or leave the SCENE parameter empty for the default display.
			-->
			{{STRUCTURE_3rt3\| PDB=3rt3 \| SCENE= }}

	~~Authors: Wang, X.Q, Li, L.~~		===Complex of influenza virus protein with host anti-viral factor===

	~~Description~~: ~~Complex of influenza~~ virus protein ~~with host anti~~-viral ~~factor~~
			==About this Structure==
			[[3rt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT3 OCA].
			[[Category: Homo sapiens]]
			[[Category: Influenza b virus]]
			[[Category: Li, L.]]
			[[Category: Wang, X Q]]
			[[Category: Antiviral protein-viral protein complex]]
			[[Category: Isgylation]]
			[[Category: Ubiquitin-like domain]]

OCA at 05:09, 25 May 2011

2011-05-25T05:09:35Z

← Older revision		Revision as of 05:09, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3rt3 is ON HOLD		The entry 3rt3 is ON HOLD until Paper Publication

	Authors: Wang, X.Q, Li, L.		Authors: Wang, X.Q, Li, L.

	Description: Complex of influenza virus protein with host anti-viral factor		Description: Complex of influenza virus protein with host anti-viral factor

OCA: Protected "3rt3" [edit=sysop:move=sysop]

2011-05-12T04:23:51Z

Protected "3rt3" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:23, 12 May 2011
(No difference)