3s8d - Revision history

OCA at 08:09, 9 October 2024

2024-10-09T08:09:03Z

← Older revision		Revision as of 08:09, 9 October 2024
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	<StructureSection load='3s8d' size='340' side='right'caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3s8d' size='340' side='right'caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8D FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3qli\|3qli]]~~, [[~~3qlk~~\|~~3qlk~~]]~~</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>aCH1, y2385, YPO1926, YP_1668 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~632~~ "~~Bacillus pestis~~" ~~(Lehmann and Neumann 1896) Migula 1900])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [https://pdbe.org/3s8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [https://www.ebi.ac.uk/pdbsum/3s8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [https://pdbe.org/3s8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [https://www.ebi.ac.uk/pdbsum/3s8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8d ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9ZC36_YERPE Q9ZC36_YERPE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Goulding, C W~~]]		[[Category: Yersinia pestis]]
	[[Category: ~~Torres, R~~]]		[[Category: Goulding CW]]
	[[Category: ~~4-hydroxybutyryl coa transferase]]~~		[[Category: Torres R]]
	~~[[Category: Coa transferase]]~~
	~~[[Category: Transferase~~]]

OCA at 10:42, 22 June 2022

2022-06-22T10:42:23Z

← Older revision		Revision as of 10:42, 22 June 2022
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	==Crystal Structure of RipA from Yersinia pestis==		==Crystal Structure of RipA from Yersinia pestis==
	<StructureSection load='3s8d' size='340' side='right' caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3s8d' size='340' side='right'caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8D FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qli\|3qli]], [[3qlk\|3qlk]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [~~http~~://pdbe.org/3s8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [https://pdbe.org/3s8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [https://www.ebi.ac.uk/pdbsum/3s8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Goulding, C W]]		[[Category: Goulding, C W]]
	[[Category: Torres,R]]		[[Category: Torres, R]]
	[[Category: 4-hydroxybutyryl coa transferase]]		[[Category: 4-hydroxybutyryl coa transferase]]
	[[Category: Coa transferase]]		[[Category: Coa transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 20:27, 11 August 2016

2016-08-11T20:27:13Z

← Older revision		Revision as of 20:27, 11 August 2016
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	==Crystal Structure of RipA from Yersinia pestis==		==Crystal Structure of RipA from Yersinia pestis==
	<StructureSection load='3s8d' size='340' side='right' caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3s8d' size='340' side='right' caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Yersinia_pestis Yersinia~~ pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8D FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 ~~Yersinia~~ pestis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [http://www.ebi.ac.uk/pdbsum/3s8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [http://pdbe.org/3s8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [http://www.ebi.ac.uk/pdbsum/3s8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3s8d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Yersinia pestis]]~~
	[[Category: Goulding, C W]]		[[Category: Goulding, C W]]
	[[Category: Torres,R]]		[[Category: Torres,R]]

OCA at 10:11, 4 January 2015

2015-01-04T10:11:12Z

← Older revision		Revision as of 10:11, 4 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8D FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [http://www.ebi.ac.uk/pdbsum/3s8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [http://www.ebi.ac.uk/pdbsum/3s8d PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.,Torres R, Swift RV, Chim N, Wheatley N, Lan B, Atwood BR, Pujol C, Sankaran B, Bliska JB, Amaro RE, Goulding CW PLoS One. 2011;6(9):e25084. Epub 2011 Sep 26. PMID:21966419<ref>PMID:21966419</ref>		Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.,Torres R, Swift RV, Chim N, Wheatley N, Lan B, Atwood BR, Pujol C, Sankaran B, Bliska JB, Amaro RE, Goulding CW PLoS One. 2011;6(9):e25084. Epub 2011 Sep 26. PMID:21966419<ref>PMID:21966419</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Goulding, C W.]]		[[Category: Goulding, C W]]
	[[Category: Torres,R.]]		[[Category: Torres,R]]
	[[Category: 4-hydroxybutyryl coa transferase]]		[[Category: 4-hydroxybutyryl coa transferase]]
	[[Category: Coa transferase]]		[[Category: Coa transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:31, 5 June 2014

2014-06-05T05:31:13Z

← Older revision		Revision as of 05:31, 5 June 2014
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	[[~~Image~~:~~3s8d~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Crystal Structure of RipA from Yersinia pestis==
			<StructureSection load='3s8d' size='340' side='right' caption='[[3s8d]], [[Resolution\|resolution]] 2.31Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3s8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8D FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qli\|3qli]], [[3qlk\|3qlk]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aCH1, y2385, YPO1926, YP_1668 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8d RCSB], [http://www.ebi.ac.uk/pdbsum/3s8d PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human diseases are attributed in part to the ability of pathogens to evade the eukaryotic immune systems. A subset of these pathogens has developed mechanisms to survive in human macrophages. Yersinia pestis, the causative agent of the bubonic plague, is a predominately extracellular pathogen with the ability to survive and replicate intracellularly. A previous study has shown that a novel rip (required for intracellular proliferation) operon (ripA, ripB and ripC) is essential for replication and survival of Y. pestis in postactivated macrophages, by playing a role in lowering macrophage-produced nitric oxide (NO) levels. A bioinformatics analysis indicates that the rip operon is conserved among a distally related subset of macrophage-residing pathogens, including Burkholderia and Salmonella species, and suggests that this previously uncharacterized pathway is also required for intracellular survival of these pathogens. The focus of this study is ripA, which encodes for a protein highly homologous to 4-hydroxybutyrate-CoA transferase; however, biochemical analysis suggests that RipA functions as a butyryl-CoA transferase. The 1.9 A X-ray crystal structure reveals that RipA belongs to the class of Family I CoA transferases and exhibits a unique tetrameric state. Molecular dynamics simulations are consistent with RipA tetramer formation and suggest a possible gating mechanism for CoA binding mediated by Val227. Together, our structural characterization and molecular dynamic simulations offer insights into acyl-CoA specificity within the active site binding pocket, and support biochemical results that RipA is a butyryl-CoA transferase. We hypothesize that the end product of the rip operon is butyrate, a known anti-inflammatory, which has been shown to lower NO levels in macrophages. Thus, the results of this molecular study of Y. pestis RipA provide a structural platform for rational inhibitor design, which may lead to a greater understanding of the role of RipA in this unique virulence pathway.

	~~<!--~~		Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.,Torres R, Swift RV, Chim N, Wheatley N, Lan B, Atwood BR, Pujol C, Sankaran B, Bliska JB, Amaro RE, Goulding CW PLoS One. 2011;6(9):e25084. Epub 2011 Sep 26. PMID:21966419<ref>PMID:21966419</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3s8d"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3s8d\| PDB=3s8d \| SCENE= }}~~

	~~===Crystal Structure~~ of ~~RipA from Yersinia pestis===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21966419}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21966419 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_21966419}}~~

	~~==About this Structure==~~
	~~[[3s8d]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8D OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:021966419<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Goulding, C W.]]		[[Category: Goulding, C W.]]

OCA at 10:47, 18 January 2012

2012-01-18T10:47:24Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3s8d.jpg|left|200px]]
-The entry 3s8d is ON HOLD  until Paper Publication
+<!--
-Authors: Torres,R., Goulding, C.W.
+===Crystal Structure of RipA from Yersinia pestis===
-Description: Crystal Structure of RipA from Yersinia pestis

OCA at 08:35, 30 October 2011

2011-10-30T08:35:34Z

← Older revision		Revision as of 08:35, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3s8d is ON HOLD		The entry 3s8d is ON HOLD until Paper Publication

	Authors: Torres,R., Goulding, C.W.		Authors: Torres,R., Goulding, C.W.

	Description: Crystal Structure of RipA from Yersinia pestis		Description: Crystal Structure of RipA from Yersinia pestis

OCA: Protected "3s8d" [edit=sysop:move=sysop]

2011-06-08T04:54:35Z

Protected "3s8d" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:54, 8 June 2011
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3s8d is ON HOLD Authors: Torres,R., Goulding, C.W. Description: Crystal Structure of RipA from Yersinia pestis

2011-06-08T04:54:34Z

New page: '''Unreleased structure''' The entry 3s8d is ON HOLD Authors: Torres,R., Goulding, C.W. Description: Crystal Structure of RipA from Yersinia pestis

New page

'''Unreleased structure'''

The entry 3s8d is ON HOLD

Authors: Torres,R., Goulding, C.W.

Description: Crystal Structure of RipA from Yersinia pestis