3sol - Revision history

OCA at 08:04, 29 June 2022

2022-06-29T08:04:06Z

← Older revision		Revision as of 08:04, 29 June 2022
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	==Crystal structure of the type 2 secretion system pilotin GspS==		==Crystal structure of the type 2 secretion system pilotin GspS==
	<StructureSection load='3sol' size='340' side='right' caption='[[3sol]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3sol' size='340' side='right'caption='[[3sol]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sol]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SOL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sol]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECO57PM13, etpO, GSPS, L7044 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECO57PM13, etpO, GSPS, L7044 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sol OCA], [~~http~~://pdbe.org/3sol PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sol RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sol PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sol ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sol OCA], [https://pdbe.org/3sol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sol RCSB], [https://www.ebi.ac.uk/pdbsum/3sol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sol ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Eco57]]		[[Category: Eco57]]
			[[Category: Large Structures]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Korotkov, K V]]		[[Category: Korotkov, K V]]

OCA at 09:54, 4 August 2016

2016-08-04T09:54:54Z

← Older revision		Revision as of 09:54, 4 August 2016
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	==Crystal structure of the type 2 secretion system pilotin GspS==		==Crystal structure of the type 2 secretion system pilotin GspS==
	<StructureSection load='3sol' size='340' side='right' caption='[[3sol]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3sol' size='340' side='right' caption='[[3sol]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_o157:h7 Escherichia coli o157:h7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SOL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SOL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECO57PM13, etpO, GSPS, L7044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ~~Escherichia coli O157:H7~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECO57PM13, etpO, GSPS, L7044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sol RCSB], [http://www.ebi.ac.uk/pdbsum/3sol PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sol OCA], [http://pdbe.org/3sol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sol RCSB], [http://www.ebi.ac.uk/pdbsum/3sol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sol ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3sol" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli o157:h7~~]]		[[Category: Eco57]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Korotkov, K V]]		[[Category: Korotkov, K V]]

OCA at 06:45, 21 December 2014

2014-12-21T06:45:13Z

← Older revision		Revision as of 06:45, 21 December 2014
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	~~{{STRUCTURE_3sol\| PDB=3sol \| SCENE= }}~~		==Crystal structure of the type 2 secretion system pilotin GspS==
	===Crystal structure of the type 2 secretion system pilotin GspS===		<StructureSection load='3sol' size='340' side='right' caption='[[3sol]], [[Resolution\|resolution]] 1.90Å' scene=''>
	~~{{ABSTRACT_PUBMED_23458689}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SOL FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECO57PM13, etpO, GSPS, L7044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 Escherichia coli O157:H7])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sol RCSB], [http://www.ebi.ac.uk/pdbsum/3sol PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Bacteria contain several sophisticated macromolecular machineries responsible for translocating proteins across the cell envelope. One prominent example is the type II secretion system (T2SS), which contains a large outer membrane channel, called the secretin. These gated channels require specialized proteins, so-called pilotins, to reach and assemble in the outer membrane. Here we report the crystal structure of the pilotin GspS from the T2SS of enterohemorrhagic Escherichia coli (EHEC), an important pathogen that can cause severe disease in cases of food poisoning. In this four-helix protein, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. The helices of GspS create a prominent groove, mainly formed by side chains of helices alpha1, alpha2 and alpha3. In the EHEC GspS structure this groove is occupied by extra electron density which is reminiscent of an alpha-helix and corresponds well with a binding site observed in a homologous pilotin. The residues forming the groove are well conserved among homologs, pointing to a key role of this groove in this class of T2SS pilotins. At the same time, T2SS pilotins in different species can be entirely different in structure, and the pilotins for secretins in non-T2SS machineries have yet again unrelated folds, despite a common function. It is striking that a common complex function, such as targeting and assembling an outer membrane multimeric channel, can be performed by proteins with entirely different folds.

	~~==About this Structure==~~		Crystal structure of the pilotin from the enterohemorrhagic Escherichia coli type II secretion system.,Korotkov KV, Hol WG J Struct Biol. 2013 May;182(2):186-91. doi: 10.1016/j.jsb.2013.02.013. Epub 2013 , Feb 28. PMID:23458689<ref>PMID:23458689</ref>
	~~[[3sol]] is a 1 chain~~ structure ~~with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_o157~~:~~h7 Escherichia coli o157~~:~~h7]~~. ~~Full crystallographic information is available from [http:~~/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3SOL OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023458689</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Escherichia coli o157:h7]]		[[Category: Escherichia coli o157:h7]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J]]
	[[Category: Korotkov, K V.]]		[[Category: Korotkov, K V]]
	[[Category: General secretory pathway]]		[[Category: General secretory pathway]]
	[[Category: Pilotin]]		[[Category: Pilotin]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Secretin]]		[[Category: Secretin]]

OCA at 13:42, 19 June 2013

2013-06-19T13:42:34Z

← Older revision		Revision as of 13:42, 19 June 2013
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	{{STRUCTURE_3sol\| PDB=3sol \| SCENE= }}		{{STRUCTURE_3sol\| PDB=3sol \| SCENE= }}
	===Crystal structure of the type 2 secretion system pilotin GspS===		===Crystal structure of the type 2 secretion system pilotin GspS===
			{{ABSTRACT_PUBMED_23458689}}

	==About this Structure==		==About this Structure==
	[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA].		[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA].
	[[Category: Escherichia coli]]
			==Reference==
			<ref group="xtra">PMID:023458689</ref><references group="xtra"/><references/>
			[[Category: Escherichia coli o157:h7]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]
	[[Category: Korotkov, K V.]]		[[Category: Korotkov, K V.]]

OCA at 07:54, 16 May 2013

2013-05-16T07:54:34Z

@@ Line 1: / Line 1: @@
 {{STRUCTURE_3sol|  PDB=3sol  |  SCENE=  }}
 ===Crystal structure of the type 2 secretion system pilotin GspS===
 ==About this Structure==

OCA at 07:53, 13 July 2011

2011-07-13T07:53:30Z

← Older revision		Revision as of 07:53, 13 July 2011
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	~~'''Unreleased structure'''~~		[[Image:3sol.jpg\|left\|200px]]

	The ~~entry~~ 3sol ~~is ON HOLD~~		<!--
			The line below this paragraph, containing "STRUCTURE_3sol", creates the "Structure Box" on the page.
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			{{STRUCTURE_3sol\| PDB=3sol \| SCENE= }}

	~~Authors: Korotkov, Konstantin V., Hol, Wim G.J.~~		===Crystal structure of the type 2 secretion system pilotin GspS===

	~~Description~~: ~~Crystal structure of the type 2 secretion system pilotin GspS~~
			==About this Structure==
			[[3sol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOL OCA].
			[[Category: Escherichia coli]]
			[[Category: Hol, W G.J.]]
			[[Category: Korotkov, K V.]]
			[[Category: General secretory pathway]]
			[[Category: Pilotin]]
			[[Category: Protein transport]]
			[[Category: Secretin]]

OCA: Protected "3sol" [edit=sysop:move=sysop]

2011-07-06T18:31:02Z

Protected "3sol" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:31, 6 July 2011
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3sol is ON HOLD Authors: Korotkov, Konstantin V., Hol, Wim G.J. Description: Crystal structure of the type 2 secretion system pilotin GspS

2011-07-06T18:31:01Z

New page: '''Unreleased structure''' The entry 3sol is ON HOLD Authors: Korotkov, Konstantin V., Hol, Wim G.J. Description: Crystal structure of the type 2 secretion system pilotin GspS

New page

'''Unreleased structure'''

The entry 3sol is ON HOLD

Authors: Korotkov, Konstantin V., Hol, Wim G.J.

Description: Crystal structure of the type 2 secretion system pilotin GspS