3swt - Revision history

OCA at 09:57, 1 March 2024

2024-03-01T09:57:49Z

← Older revision		Revision as of 09:57, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3swt' size='340' side='right'caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3swt' size='340' side='right'caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycmm Mycmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [https://pdbe.org/3swt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [https://www.ebi.ac.uk/pdbsum/3swt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [https://pdbe.org/3swt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [https://www.ebi.ac.uk/pdbsum/3swt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swt ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style~~=~~"background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed ==~~		[https://www.uniprot.org/uniprot/B2HD26_MYCMM B2HD26_MYCMM]
	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.

	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~

	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"><~~/~~div>~~

	==See Also==		==See Also==
	*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]		*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Mycmm]]~~		[[Category: Mycobacterium marinum M]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Dioxygenase]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Ssgcid]]~~
	~~[[Category: Taud]]~~
	~~[[Category: Taurine catabolism dioxygenase~~]]

OCA at 08:13, 29 June 2022

2022-06-29T08:13:52Z

← Older revision		Revision as of 08:13, 29 June 2022
Line 1:		Line 1:

	==Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum==		==Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum==
	<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3swt' size='340' side='right'caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [~~http~~://pdbe.org/3swt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3swt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3swt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [https://pdbe.org/3swt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [https://www.ebi.ac.uk/pdbsum/3swt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mycmm]]		[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 09:44, 8 November 2017

2017-11-08T09:44:38Z

← Older revision		Revision as of 09:44, 8 November 2017
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Dioxygenase\|Dioxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:17, 18 January 2017

2017-01-18T17:17:10Z

← Older revision		Revision as of 17:17, 18 January 2017
Line 1:		Line 1:

	==Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum==		==Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum==
	<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://pdbe.org/3swt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3swt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3swt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:21, 15 April 2015

2015-04-15T06:21:01Z

← Older revision		Revision as of 06:21, 15 April 2015
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

			==See Also==
			*[[Dioxygenase\|Dioxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:39, 11 March 2015

2015-03-11T05:39:27Z

@@ Line 7: / Line 7: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>
 </table>
 __TOC__
 </StructureSection>

OCA at 10:51, 25 January 2015

2015-01-25T10:51:01Z

← Older revision		Revision as of 10:51, 25 January 2015
Line 2:		Line 2:
	<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Dioxygenase]]		[[Category: Dioxygenase]]

OCA at 07:30, 12 November 2014

2014-11-12T07:30:29Z

← Older revision		Revision as of 07:30, 12 November 2014
Line 2:		Line 2:
	<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum_m Mycobacterium marinum m]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SWT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~<br>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 Mycobacterium marinum M])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>		</table>
	<table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium marinum m]]~~		[[Category: Structural genomic]]
	~~[[Category: SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]
	[[Category: Dioxygenase]]		[[Category: Dioxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	~~[[Category: Seattle structural genomics center for infectious disease]]~~
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
	[[Category: Taud]]		[[Category: Taud]]
	[[Category: Taurine catabolism dioxygenase]]		[[Category: Taurine catabolism dioxygenase]]

OCA at 05:18, 5 June 2014

2014-06-05T05:18:26Z

← Older revision		Revision as of 05:18, 5 June 2014
Line 1:		Line 1:
	~~[[Image:3swt.jpg\|left\|200px]]~~		==Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum==
			<StructureSection load='3swt' size='340' side='right' caption='[[3swt]], [[Resolution\|resolution]] 2.05Å' scene=''>
	~~<!--~~		== Structural highlights ==
	~~The line below this paragraph, containing "STRUCTURE_3swt", creates the "Structure Box" on the page.~~		<table><tr><td colspan='2'>[[3swt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum_m Mycobacterium marinum m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SWT FirstGlance]. <br>
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~		<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tauD, MMAR_1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 Mycobacterium marinum M])</td></tr>
	~~or leave the SCENE parameter empty for the default display.~~		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3swt RCSB], [http://www.ebi.ac.uk/pdbsum/3swt PDBsum]</span></td></tr>
	~~-->~~		<table>
	~~{{STRUCTURE_3swt\| PDB=3swt \| SCENE= }}~~		__TOC__
			</StructureSection>
	===Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum===


	==~~About this Structure~~==
	[[3swt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum_m Mycobacterium marinum m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWT OCA].
	[[Category: Mycobacterium marinum m]]		[[Category: Mycobacterium marinum m]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 09:04, 3 August 2011

2011-08-03T09:04:29Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3swt.jpg|left|200px]]
-The entry 3swt is ON HOLD
+<!--
-Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
+===Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum===
-Description: Crystal Structure of the Taurine catabolism dioxygenase, TauD from Mycobacterium marinum