3tc7 - Revision history

OCA at 13:23, 14 March 2024

2024-03-14T13:23:51Z

← Older revision		Revision as of 13:23, 14 March 2024
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	<StructureSection load='3tc7' size='340' side='right'caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3tc7' size='340' side='right'caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sacs2 Sacs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC7 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3tc6\|3tc6]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>trpC, SSO0895 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~273057 SACS2])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [https://pdbe.org/3tc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [https://pdbe.org/3tc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc7 ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style~~=~~"background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed ==~~		[https://www.uniprot.org/uniprot/TRPC_SACS2 TRPC_SACS2]
	Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of beta-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and to function as a general acid/base. Here we investigate an alternative active-site design in which the catalytic water molecule was replaced by the side chain of a glutamic acid. Five out of seven designs expressed solubly and exhibited catalytic efficiencies similar to previously designed retroaldolases for the conversion of 4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone to 6-methoxy-2-naphthaldehyde and acetone. After one round of site-directed saturation mutagenesis, improved variants of the two best designs, RA114 and RA117, exhibited among the highest kcat (>10-3s-1) and kcat/KM (11-25M-1s-1) values observed for retroaldolase designs prior to comprehensive directed evolution. In both cases, the >105-fold rate accelerations that were achieved are within 1-3 orders of magnitude of the rate enhancements reported for the best catalysts for related reactions, including catalytic antibodies (kcat/kuncat=106 to 108) and an extensively evolved computational design (kcat/kuncat>107). The catalytic sites, revealed by X-ray structures of optimized versions of the two active designs, are in close agreement with the design models except for the catalytic lysine in RA114. We further improved the variants by computational remodeling of the loops and yeast display selection for reactivity of the catalytic lysine with a diketone probe, obtaining an additional order of magnitude enhancement in activity with both approaches.

	Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design.,Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D J Mol Biol. 2013 Oct 23. pii: S0022-2836(13)00655-4. doi:, 10.1016/j.jmb.2013.10.012. PMID:~~24161950<ref>PMID:24161950<~~/~~ref>~~

	~~From MEDLINE®~~/~~PubMed®, a database of the U.S~~. ~~National Library of Medicine~~.~~<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 3tc7" style="background-color:#fffaf0;"><~~/~~div>~~

	==See Also==		==See Also==
	*[[~~Indole-3-glycerol phosphate synthase~~\|~~Indole-3-glycerol phosphate synthase~~]]		*[[IGPS 3D structures\|IGPS 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Indole-3-glycerol-phosphate synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Sacs2~~]]		[[Category: Saccharolobus solfataricus P2]]
	[[Category: Acton~~, T B~~]]		[[Category: Acton TB]]
	[[Category: Baker, D]]		[[Category: Baker D]]
	[[Category: Bjelic, S]]		[[Category: Bjelic S]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti C]]
	[[Category: Everett~~, J K~~]]		[[Category: Everett JK]]
	[[Category: Hunt~~, J F~~]]		[[Category: Hunt JF]]
	[[Category: Kipnis, Y]]		[[Category: Kipnis Y]]
	[[Category: Montelione~~, G T]]~~		[[Category: Montelione GT]]
	~~[[Category: Structural genomic~~]]		[[Category: Sahdev S]]
	[[Category: Sahdev, S]]		[[Category: Seetharaman J]]
	[[Category: Seetharaman, J]]		[[Category: Su M]]
	[[Category: Su, M]]		[[Category: Tong L]]
	[[Category: Tong, L]]		[[Category: Vorobiev S]]
	[[Category: Vorobiev, S]]		[[Category: Wang L]]
	[[Category: Wang, L]]		[[Category: Xiao R]]
	[[Category: Xiao, R]]
	~~[[Category: Engineered protein]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Nesg]]~~
	~~[[Category: Or62]]~~
	~~[[Category: PSI, Protein structure initiative]]~~
	~~[[Category: Psi-biology~~]]

OCA at 16:51, 6 July 2022

2022-07-06T16:51:41Z

← Older revision		Revision as of 16:51, 6 July 2022
Line 1:		Line 1:

	==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.==		==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.==
	<StructureSection load='3tc7' size='340' side='right' caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3tc7' size='340' side='right'caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tc7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Sulso Sulso~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sacs2 Sacs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tc6\|3tc6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tc6\|3tc6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpC, SSO0895 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 ~~SULSO~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpC, SSO0895 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SACS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [~~http~~://pdbe.org/3tc7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tc7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [https://pdbe.org/3tc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Indole-3-glycerol-phosphate synthase]]		[[Category: Indole-3-glycerol-phosphate synthase]]
	[[Category: ~~Sulso~~]]		[[Category: Large Structures]]
			[[Category: Sacs2]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Baker, D]]		[[Category: Baker, D]]

OCA at 23:40, 4 August 2016

2016-08-04T23:40:06Z

← Older revision		Revision as of 23:40, 4 August 2016
Line 1:		Line 1:

	==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.==		==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.==
	<StructureSection load='3tc7' size='340' side='right' caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3tc7' size='340' side='right' caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpC, SSO0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SULSO])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpC, SSO0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SULSO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [http://pdbe.org/3tc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3tc7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:45, 21 December 2014

2014-12-21T18:45:31Z

← Older revision		Revision as of 18:45, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3tc7\| PDB=3tc7 \| SCENE= }}~~		==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.==
	===Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.===		<StructureSection load='3tc7' size='340' side='right' caption='[[3tc7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_24161950}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3tc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TC7 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tc6\|3tc6]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpC, SSO0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SULSO])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc7 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc7 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of beta-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and to function as a general acid/base. Here we investigate an alternative active-site design in which the catalytic water molecule was replaced by the side chain of a glutamic acid. Five out of seven designs expressed solubly and exhibited catalytic efficiencies similar to previously designed retroaldolases for the conversion of 4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone to 6-methoxy-2-naphthaldehyde and acetone. After one round of site-directed saturation mutagenesis, improved variants of the two best designs, RA114 and RA117, exhibited among the highest kcat (>10-3s-1) and kcat/KM (11-25M-1s-1) values observed for retroaldolase designs prior to comprehensive directed evolution. In both cases, the >105-fold rate accelerations that were achieved are within 1-3 orders of magnitude of the rate enhancements reported for the best catalysts for related reactions, including catalytic antibodies (kcat/kuncat=106 to 108) and an extensively evolved computational design (kcat/kuncat>107). The catalytic sites, revealed by X-ray structures of optimized versions of the two active designs, are in close agreement with the design models except for the catalytic lysine in RA114. We further improved the variants by computational remodeling of the loops and yeast display selection for reactivity of the catalytic lysine with a diketone probe, obtaining an additional order of magnitude enhancement in activity with both approaches.

	~~==About this Structure==~~		Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design.,Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D J Mol Biol. 2013 Oct 23. pii: S0022-2836(13)00655-4. doi:, 10.1016/j.jmb.2013.10.012. PMID:24161950<ref>PMID:24161950</ref>
	~~[[3tc7]] is a 1 chain structure with sequence from [http~~:/~~/en~~.~~wikipedia~~.~~org/wiki/Sulso Sulso]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3TC7 OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Indole-3-glycerol phosphate synthase\|Indole-3-glycerol phosphate synthase]]		*[[Indole-3-glycerol phosphate synthase\|Indole-3-glycerol phosphate synthase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:024161950</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Indole-3-glycerol-phosphate synthase]]		[[Category: Indole-3-glycerol-phosphate synthase]]
	[[Category: Sulso]]		[[Category: Sulso]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B]]
	[[Category: Baker, D.]]		[[Category: Baker, D]]
	[[Category: Bjelic, S.]]		[[Category: Bjelic, S]]
	[[Category: Ciccosanti, C.]]		[[Category: Ciccosanti, C]]
	[[Category: Everett, J K.]]		[[Category: Everett, J K]]
	[[Category: Hunt, J F.]]		[[Category: Hunt, J F]]
	[[Category: Kipnis, Y.]]		[[Category: Kipnis, Y]]
	[[Category: Montelione, G T.]]		[[Category: Montelione, G T]]
	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Sahdev, S.]]		[[Category: Sahdev, S]]
	[[Category: Seetharaman, J.]]		[[Category: Seetharaman, J]]
	[[Category: Su, M.]]		[[Category: Su, M]]
	[[Category: Tong, L.]]		[[Category: Tong, L]]
	[[Category: Vorobiev, S.]]		[[Category: Vorobiev, S]]
	[[Category: Wang, L.]]		[[Category: Wang, L]]
	[[Category: Xiao, R.]]		[[Category: Xiao, R]]
	[[Category: Engineered protein]]		[[Category: Engineered protein]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Nesg]]		[[Category: Nesg]]
	~~[[Category: Northeast structural genomics consortium]]~~
	[[Category: Or62]]		[[Category: Or62]]
	[[Category: Protein structure initiative]]		[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]

OCA at 08:20, 8 January 2014

2014-01-08T08:20:22Z

← Older revision		Revision as of 08:20, 8 January 2014
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[3tc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA].		[[3tc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA].

			==See Also==
			*[[Indole-3-glycerol phosphate synthase\|Indole-3-glycerol phosphate synthase]]

	==Reference==		==Reference==

OCA at 05:57, 4 December 2013

2013-12-04T05:57:22Z

← Older revision		Revision as of 05:57, 4 December 2013
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	~~[[Image:3tc7.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3tc7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3tc7\| PDB=3tc7 \| SCENE= }}		{{STRUCTURE_3tc7\| PDB=3tc7 \| SCENE= }}

	===Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.===		===Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.===
			{{ABSTRACT_PUBMED_24161950}}

			==About this Structure==
			[[3tc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA].

	==~~About this Structure~~==		==Reference==
	~~[[3tc7]] is a 1 chain structure with sequence from [http~~://~~en.wikipedia.org~~/~~wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC7 OCA].~~		<ref group="xtra">PMID:024161950</ref><references group="xtra"/><references/>
	[[Category: Indole-3-glycerol-phosphate synthase]]		[[Category: Indole-3-glycerol-phosphate synthase]]
	[[Category: ~~Sulfolobus solfataricus p2~~]]		[[Category: Sulso]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
	[[Category: Baker, D.]]		[[Category: Baker, D.]]

OCA at 07:51, 24 August 2011

2011-08-24T07:51:30Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3tc7.jpg|left|200px]]
-The entry 3tc7 is ON HOLD
+<!--
-Authors: Vorobiev,S., Su, M., Bjelic, S., Kipnis, Y., Wang, L., Seetharaman, J., Sahdev,S., Xiao,R., Ciccosanti,C., Baker,D., Everett J.K., Acton T.B., Montelione, G.T., Hunt,J.F., Tong,L., Northeast Structural Genomics Consortium (NESG)
+===Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.===
-Description: Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.

OCA: Protected "3tc7" [edit=sysop:move=sysop]

2011-08-17T05:56:51Z

Protected "3tc7" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:56, 17 August 2011
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3tc7 is ON HOLD Authors: Vorobiev,S., Su, M., Bjelic, S., Kipnis, Y., Wang, L., Seetharaman, J., Sahdev,S., Xiao,R., Ciccosanti,C., Baker,D., Everet...

2011-08-17T05:56:50Z

New page: '''Unreleased structure''' The entry 3tc7 is ON HOLD Authors: Vorobiev,S., Su, M., Bjelic, S., Kipnis, Y., Wang, L., Seetharaman, J., Sahdev,S., Xiao,R., Ciccosanti,C., Baker,D., Everet...

New page

'''Unreleased structure'''

The entry 3tc7 is ON HOLD

Authors: Vorobiev,S., Su, M., Bjelic, S., Kipnis, Y., Wang, L., Seetharaman, J., Sahdev,S., Xiao,R., Ciccosanti,C., Baker,D., Everett J.K., Acton T.B., Montelione, G.T., Hunt,J.F., Tong,L., Northeast Structural Genomics Consortium (NESG)

Description: Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62.