3tk6 - Revision history

OCA at 10:28, 6 November 2024

2024-11-06T10:28:56Z

← Older revision		Revision as of 10:28, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [https://pdbe.org/3tk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [https://pdbe.org/3tk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>		[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Coagulation factor Xa]]~~
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kanno, H]]		[[Category: Kanno H]]
	[[Category: Kishida, M]]		[[Category: Kishida M]]
	[[Category: Mochizuki, A]]		[[Category: Mochizuki A]]
	[[Category: Nagata, T]]		[[Category: Nagata T]]
	[[Category: Ohta, T]]		[[Category: Ohta T]]
	[[Category: Suzuki, M]]		[[Category: Suzuki M]]
	[[Category: Takano, H]]		[[Category: Takano H]]
	~~[[Category: Blood]]~~
	~~[[Category: Calcium-binding]]~~
	~~[[Category: Coagulation factor]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Plasma]]~~
	~~[[Category: Serine protease~~]]

OCA at 17:01, 6 July 2022

2022-07-06T17:01:46Z

← Older revision		Revision as of 17:01, 6 July 2022
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	<StructureSection load='3tk6' size='340' side='right'caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tk6' size='340' side='right'caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [~~http~~://pdbe.org/3tk6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [https://pdbe.org/3tk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>		[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==See Also==		==See Also==

OCA at 18:05, 14 August 2019

2019-08-14T18:05:01Z

← Older revision		Revision as of 18:05, 14 August 2019
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	==factor Xa in complex with D46-5241==		==factor Xa in complex with D46-5241==
	<StructureSection load='3tk6' size='340' side='right' caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tk6' size='340' side='right'caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

			==See Also==
			*[[Factor Xa\|Factor Xa]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Large Structures]]
	[[Category: Kanno, H]]		[[Category: Kanno, H]]
	[[Category: Kishida, M]]		[[Category: Kishida, M]]

OCA at 09:52, 8 November 2017

2017-11-08T09:52:30Z

← Older revision		Revision as of 09:52, 8 November 2017
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	~~==See Also==~~
	*[[Factor Xa\|Factor Xa]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:31, 11 August 2016

2016-08-11T09:31:15Z

← Older revision		Revision as of 09:31, 11 August 2016
Line 1:		Line 1:

	==factor Xa in complex with D46-5241==		==factor Xa in complex with D46-5241==
	<StructureSection load='3tk6' size='340' side='right' caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tk6' size='340' side='right' caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tk6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [http://pdbe.org/3tk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 14:43, 5 January 2015

2015-01-05T14:43:52Z

← Older revision		Revision as of 14:43, 5 January 2015
Line 1:		Line 1:
	~~{{STRUCTURE_3tk6~~\| ~~PDB~~=3tk6 \| ~~SCENE~~= }}		==factor Xa in complex with D46-5241==
	===factor Xa ~~in complex~~ with ~~D46~~-~~5241~~===		<StructureSection load='3tk6' size='340' side='right' caption='[[3tk6]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TK6 FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=D46:N-[2-({[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}METHYL)PHENYL]-5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE'>D46</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ei6\|2ei6]], [[2ei7\|2ei7]], [[2ei8\|2ei8]], [[1v3x\|1v3x]], [[1wu1\|1wu1]], [[2d1j\|2d1j]], [[3tk5\|3tk5]]</td></tr>
	==Function==		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tk6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tk6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tk6 PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.		[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	~~==About this Structure==~~
	[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA].

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
			== References ==
	==~~Reference~~==		<references/>
	<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kanno, H.]]		[[Category: Kanno, H]]
	[[Category: Kishida, M.]]		[[Category: Kishida, M]]
	[[Category: Mochizuki, A.]]		[[Category: Mochizuki, A]]
	[[Category: Nagata, T.]]		[[Category: Nagata, T]]
	[[Category: Ohta, T.]]		[[Category: Ohta, T]]
	[[Category: Suzuki, M.]]		[[Category: Suzuki, M]]
	[[Category: Takano, H.]]		[[Category: Takano, H]]
	[[Category: Blood]]		[[Category: Blood]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]

OCA at 16:28, 24 March 2013

2013-03-24T16:28:58Z

← Older revision		Revision as of 16:28, 24 March 2013
Line 1:		Line 1:
	~~[[Image:3tk6.jpg\|left\|200px]]~~

	{{STRUCTURE_3tk6\| PDB=3tk6 \| SCENE= }}		{{STRUCTURE_3tk6\| PDB=3tk6 \| SCENE= }}
			===factor Xa in complex with D46-5241===

	===factor ~~Xa in complex~~ with ~~D46-5241===~~		==Disease==
			[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
	[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA].		[[3tk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK6 OCA].

			==See Also==
			*[[Factor Xa\|Factor Xa]]

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:17, 29 August 2012

2012-08-29T05:17:47Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3tk6.jpg|left|200px]]
-The entry 3tk6 is ON HOLD  until Aug 25 2013
+{{STRUCTURE_3tk6|  PDB=3tk6  |  SCENE=  }}
-Authors: Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
+===factor Xa in complex with D46-5241===
-Description: factor Xa in complex with D46-5241

OCA at 07:31, 7 December 2011

2011-12-07T07:31:37Z

← Older revision		Revision as of 07:31, 7 December 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3tk6 is ON HOLD		The entry 3tk6 is ON HOLD until Aug 25 2013

	Authors: Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.		Authors: Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.

	Description: factor Xa in complex with D46-5241		Description: factor Xa in complex with D46-5241

OCA: Protected "3tk6" [edit=sysop:move=sysop]

2011-08-31T06:27:28Z

Protected "3tk6" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:27, 31 August 2011
(No difference)