3vr2 - Revision history

OCA at 12:33, 8 November 2023

2023-11-08T12:33:45Z

← Older revision		Revision as of 12:33, 8 November 2023
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	<StructureSection load='3vr2' size='340' side='right'caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3vr2' size='340' side='right'caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_8043 Atcc 8043~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	~~<tr~~ id~~='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class~~="~~sblockDat~~">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3vr3\|3vr3]]~~, [[~~3vr4~~\|~~3vr4~~]]~~, [[3vr5\|3vr5]], [[3vr6\|3vr6]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ntpA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1354 ATCC 8043]), ntpB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [https://pdbe.org/3vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [https://pdbe.org/3vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NTPA_ENTHA NTPA_ENTHA~~]] Involved in ATP-driven sodium extrusion. [[https://www.uniprot.org/uniprot/NTPB_ENTHA NTPB_ENTHA]~~] Involved in ATP-driven sodium extrusion.		[https://www.uniprot.org/uniprot/NTPA_ENTHA NTPA_ENTHA] Involved in ATP-driven sodium extrusion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 8043~~]]		[[Category: Enterococcus hirae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Sodium-transporting two-sector ATPase]]~~		[[Category: Arai S]]
	[[Category: Arai, S]]		[[Category: Ishizuka-Katsura Y]]
	[[Category: Ishizuka-Katsura, Y]]		[[Category: Iwata S]]
	[[Category: Iwata, S]]		[[Category: Kakinuma Y]]
	[[Category: Kakinuma, Y]]		[[Category: Mizutani K]]
	[[Category: Mizutani, K]]		[[Category: Murata T]]
	[[Category: Murata, T]]		[[Category: Ohsawa N]]
	[[Category: Ohsawa, N]]		[[Category: Saijo S]]
	[[Category: Saijo, S]]		[[Category: Shirouzu M]]
	[[Category: Shirouzu, M]]		[[Category: Suzuki K]]
	[[Category: Suzuki, K]]		[[Category: Terada T]]
	[[Category: Terada, T]]		[[Category: Yamato I]]
	[[Category: Yamato, I]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Atp binding]]~~
	~~[[Category: Enterococcus hirae]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: P-loop]]~~
	~~[[Category: Rotary motor]]~~
	~~[[Category: V-atpase~~]]

OCA at 18:59, 27 July 2022

2022-07-27T18:59:27Z

← Older revision		Revision as of 18:59, 27 July 2022
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	==Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]==		==Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]==
	<StructureSection load='3vr2' size='340' side='right' caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3vr2' size='340' side='right'caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_8043 Atcc 8043]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_8043 Atcc 8043]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vr3\|3vr3]], [[3vr4\|3vr4]], [[3vr5\|3vr5]], [[3vr6\|3vr6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vr3\|3vr3]], [[3vr4\|3vr4]], [[3vr5\|3vr5]], [[3vr6\|3vr6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ntpA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043]), ntpB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ntpA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043]), ntpB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [~~http~~://pdbe.org/3vr2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vr2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [https://pdbe.org/3vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NTPA_ENTHA NTPA_ENTHA]] Involved in ATP-driven sodium extrusion. [[~~http~~://www.uniprot.org/uniprot/NTPB_ENTHA NTPB_ENTHA]] Involved in ATP-driven sodium extrusion.		[[https://www.uniprot.org/uniprot/NTPA_ENTHA NTPA_ENTHA]] Involved in ATP-driven sodium extrusion. [[https://www.uniprot.org/uniprot/NTPB_ENTHA NTPB_ENTHA]] Involved in ATP-driven sodium extrusion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[ATPase\|ATPase]]		*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 8043]]		[[Category: Atcc 8043]]
			[[Category: Large Structures]]
	[[Category: Sodium-transporting two-sector ATPase]]		[[Category: Sodium-transporting two-sector ATPase]]
	[[Category: Arai, S]]		[[Category: Arai, S]]

OCA at 18:54, 10 December 2016

2016-12-10T18:54:43Z

← Older revision		Revision as of 18:54, 10 December 2016
Line 1:		Line 1:

	==Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]==		==Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]==
	<StructureSection load='3vr2' size='340' side='right' caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3vr2' size='340' side='right' caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_hirae Enterococcus hirae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_8043 Atcc 8043]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vr3\|3vr3]], [[3vr4\|3vr4]], [[3vr5\|3vr5]], [[3vr6\|3vr6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vr3\|3vr3]], [[3vr4\|3vr4]], [[3vr5\|3vr5]], [[3vr6\|3vr6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ntpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ~~Enterococcus hirae~~]), ntpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ~~Enterococcus hirae~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ntpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043]), ntpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 ATCC 8043])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [http://www.ebi.ac.uk/pdbsum/3vr2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [http://pdbe.org/3vr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [http://www.ebi.ac.uk/pdbsum/3vr2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NTPA_ENTHA NTPA_ENTHA]] Involved in ATP-driven sodium extrusion. [[http://www.uniprot.org/uniprot/NTPB_ENTHA NTPB_ENTHA]] Involved in ATP-driven sodium extrusion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3vr2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Enterococcus hirae~~]]		[[Category: Atcc 8043]]
	[[Category: Sodium-transporting two-sector ATPase]]		[[Category: Sodium-transporting two-sector ATPase]]
	[[Category: Arai, S]]		[[Category: Arai, S]]
Line 40:		Line 44:
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
			[[Category: Enterococcus hirae]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: P-loop]]		[[Category: P-loop]]
	[[Category: Rotary motor]]		[[Category: Rotary motor]]
	[[Category: V-atpase]]		[[Category: V-atpase]]

OCA at 15:28, 9 December 2014

2014-12-09T15:28:32Z

← Older revision		Revision as of 15:28, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~3vr2~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]==
			<StructureSection load='3vr2' size='340' side='right' caption='[[3vr2]], [[Resolution\|resolution]] 2.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3vr2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VR2 FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vr3\|3vr3]], [[3vr4\|3vr4]], [[3vr5\|3vr5]], [[3vr6\|3vr6]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ntpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 Enterococcus hirae]), ntpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1354 Enterococcus hirae])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium-transporting_two-sector_ATPase Sodium-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.15 3.6.3.15] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vr2 RCSB], [http://www.ebi.ac.uk/pdbsum/3vr2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In various cellular membrane systems, vacuolar ATPases (V-ATPases) function as proton pumps, which are involved in many processes such as bone resorption and cancer metastasis, and these membrane proteins represent attractive drug targets for osteoporosis and cancer. The hydrophilic V(1) portion is known as a rotary motor, in which a central axis DF complex rotates inside a hexagonally arranged catalytic A(3)B(3) complex using ATP hydrolysis energy, but the molecular mechanism is not well defined owing to a lack of high-resolution structural information. We previously reported on the in vitro expression, purification and reconstitution of Enterococcus hirae V(1)-ATPase from the A(3)B(3) and DF complexes. Here we report the asymmetric structures of the nucleotide-free (2.8 A) and nucleotide-bound (3.4 A) A(3)B(3) complex that demonstrate conformational changes induced by nucleotide binding, suggesting a binding order in the right-handed rotational orientation in a cooperative manner. The crystal structures of the nucleotide-free (2.2 A) and nucleotide-bound (2.7 A) V(1)-ATPase are also reported. The more tightly packed nucleotide-binding site seems to be induced by DF binding, and ATP hydrolysis seems to be stimulated by the approach of a conserved arginine residue. To our knowledge, these asymmetric structures represent the first high-resolution view of the rotational mechanism of V(1)-ATPase.

	~~{{STRUCTURE_3vr2\| PDB=3vr2 \| SCENE= }}~~		Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures.,Arai S, Saijo S, Suzuki K, Mizutani K, Kakinuma Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Yamato I, Murata T Nature. 2013 Jan 31;493(7434):703-7. doi: 10.1038/nature11778. Epub 2013 Jan 13. PMID:23334411<ref>PMID:23334411</ref>

	~~===Crystal structure~~ of ~~nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_23334411}}~~		==See Also==
			*[[ATPase\|ATPase]]
	==~~About this Structure~~==		== References ==
	[[~~3vr2~~]] ~~is a 6 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR2 OCA].~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Enterococcus hirae]]		[[Category: Enterococcus hirae]]
	[[Category: Sodium-transporting two-sector ATPase]]		[[Category: Sodium-transporting two-sector ATPase]]
	[[Category: Arai, S.]]		[[Category: Arai, S]]
	[[Category: Ishizuka-Katsura, Y.]]		[[Category: Ishizuka-Katsura, Y]]
	[[Category: Iwata, S.]]		[[Category: Iwata, S]]
	[[Category: Kakinuma, Y.]]		[[Category: Kakinuma, Y]]
	[[Category: Mizutani, K.]]		[[Category: Mizutani, K]]
	[[Category: Murata, T.]]		[[Category: Murata, T]]
	[[Category: Ohsawa, N.]]		[[Category: Ohsawa, N]]
	[[Category: Saijo, S.]]		[[Category: Saijo, S]]
	[[Category: Shirouzu, M.]]		[[Category: Shirouzu, M]]
	[[Category: Suzuki, K.]]		[[Category: Suzuki, K]]
	[[Category: Terada, T.]]		[[Category: Terada, T]]
	[[Category: Yamato, I.]]		[[Category: Yamato, I]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	~~[[Category: Enterococcus hirae]]~~
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: P-loop]]		[[Category: P-loop]]
	[[Category: Rotary motor]]		[[Category: Rotary motor]]
	[[Category: V-atpase]]		[[Category: V-atpase]]

OCA at 12:49, 6 February 2013

2013-02-06T12:49:35Z

← Older revision		Revision as of 12:49, 6 February 2013
Line 1:		Line 1:
	[[Image:3vr2.~~jpg~~\|left\|200px]]		[[Image:3vr2.png\|left\|200px]]

	{{STRUCTURE_3vr2\| PDB=3vr2 \| SCENE= }}		{{STRUCTURE_3vr2\| PDB=3vr2 \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]===		===Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]===

			{{ABSTRACT_PUBMED_23334411}}

	==About this Structure==		==About this Structure==

OCA at 09:04, 16 January 2013

2013-01-16T09:04:03Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3vr2.jpg|left|200px]]
-The entry 3vr2 is ON HOLD  until Paper Publication
+{{STRUCTURE_3vr2|  PDB=3vr2  |  SCENE=  }}
-Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yokoyama, S., Iwata, S., Yamato, I., Murata, T.
+===Crystal structure of nucleotide-free A3B3 complex from Enterococcus hirae V-ATPase [eA3B3]===
-Description: Crystal Structure of eA3B3

OCA at 08:38, 9 May 2012

2012-05-09T08:38:30Z

← Older revision		Revision as of 08:38, 9 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3vr2 is ON HOLD		The entry 3vr2 is ON HOLD until Paper Publication

	Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yokoyama, S., Iwata, S., Yamato, I., Murata, T.		Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yokoyama, S., Iwata, S., Yamato, I., Murata, T.

	Description: Crystal Structure of eA3B3		Description: Crystal Structure of eA3B3

OCA: Protected "3vr2" [edit=sysop:move=sysop]

2012-04-11T06:32:19Z

Protected "3vr2" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:32, 11 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3vr2 is ON HOLD Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yo...

2012-04-11T06:32:18Z

New page: '''Unreleased structure''' The entry 3vr2 is ON HOLD Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yo...

New page

'''Unreleased structure'''

The entry 3vr2 is ON HOLD

Authors: Arai, S., Saijo, S., Suzuki, K., Mizutani, K., Kakinuma, Y., Ishizuka-Katsura, Y., Ohsawa, N., Terada, T., Shirouzu, M., Yokoyama, S., Iwata, S., Yamato, I., Murata, T.

Description: Crystal Structure of eA3B3