3w15 - Revision history

OCA at 02:34, 21 November 2024

2024-11-21T02:34:56Z

← Older revision		Revision as of 02:34, 21 November 2024
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	<StructureSection load='3w15' size='340' side='right'caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3w15' size='340' side='right'caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~] and [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W15 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W15 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PEX7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=559292 Baker~~'~~s yeast])~~, ~~PEX21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=559292 Baker~~'~~s yeast]), FOX3 ([https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [https://pdbe.org/3w15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [https://www.ebi.ac.uk/pdbsum/3w15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w15 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [https://pdbe.org/3w15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [https://www.ebi.ac.uk/pdbsum/3w15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w15 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[https://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>		[https://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Baker's yeast]]~~		[[Category: Escherichia coli K-12]]
	~~[[Category: Ecoli~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Kato, H~~]]		[[Category: Saccharomyces cerevisiae S288C]]
	[[Category: ~~Nakatsu, T~~]]		[[Category: Kato H]]
	[[Category: ~~Pan, D~~]]		[[Category: Nakatsu T]]
	[[Category: ~~Beta-propeller]]~~		[[Category: Pan D]]
	~~[[Category: Cytosol]]~~
	~~[[Category: Peroxisome]]~~
	~~[[Category: Protein transport]]~~
	~~[[Category: Targeting signal recognition~~]]

OCA at 05:17, 3 August 2022

2022-08-03T05:17:36Z

← Older revision		Revision as of 05:17, 3 August 2022
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	==Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p==		==Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p==
	<StructureSection load='3w15' size='340' side='right' caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3w15' size='340' side='right'caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3W15 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W15 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX7 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PEX21 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), FOX3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PEX21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), FOX3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [~~http~~://pdbe.org/3w15 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3w15 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3w15 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [https://pdbe.org/3w15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [https://www.ebi.ac.uk/pdbsum/3w15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w15 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[~~http~~://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>		[[https://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[https://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3w15" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3w15" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Thiolase 3D structures\|Thiolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
	[[Category: Ecoli]]		[[Category: Ecoli]]
			[[Category: Large Structures]]
	[[Category: Kato, H]]		[[Category: Kato, H]]
	[[Category: Nakatsu, T]]		[[Category: Nakatsu, T]]

OCA at 00:53, 16 November 2017

2017-11-16T00:53:18Z

← Older revision		Revision as of 00:53, 16 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3w15" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3w15" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Thiolase\|Thiolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:54, 4 August 2016

2016-08-04T11:54:06Z

← Older revision		Revision as of 11:54, 4 August 2016
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	==Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p==		==Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p==
	<StructureSection load='3w15' size='340' side='right' caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3w15' size='340' side='right' caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bionectria_wenpingii Bionectria wenpingii~~], [http://en.wikipedia.org/wiki/Ecoli Ecoli~~] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W15 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W15 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~466134 Bionectria wenpingii~~]), PEX21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), FOX3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PEX21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), FOX3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [http://www.ebi.ac.uk/pdbsum/3w15 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [http://pdbe.org/3w15 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [http://www.ebi.ac.uk/pdbsum/3w15 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w15 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3w15" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bionectria wenpingii~~]]		[[Category: Baker's yeast]]
	[[Category: Ecoli]]		[[Category: Ecoli]]
	~~[[Category: Saccharomyces cerevisiae s288c]]~~
	[[Category: Kato, H]]		[[Category: Kato, H]]
	[[Category: Nakatsu, T]]		[[Category: Nakatsu, T]]

OCA at 09:02, 25 December 2014

2014-12-25T09:02:50Z

← Older revision		Revision as of 09:02, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3w15\| PDB=3w15 \| SCENE= }}~~		==Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p==
	===Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p===		<StructureSection load='3w15' size='340' side='right' caption='[[3w15]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_23812376}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii], [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W15 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PEX7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=466134 Bionectria wenpingii]), PEX21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), FOX3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w15 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w15 RCSB], [http://www.ebi.ac.uk/pdbsum/3w15 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[http://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Appropriate targeting of matrix proteins to peroxisomes is mainly directed by two types of peroxisomal targeting signals, PTS1 and PTS2. Although the basis of PTS1 recognition has been revealed by structural studies, that of PTS2 recognition remains elusive. Here we present the crystal structure of a heterotrimeric PTS2-recognition complex from Saccharomyces cerevisiae, containing Pex7p, the C-terminal region of Pex21p and the PTS2 of the peroxisomal 3-ketoacyl-CoA thiolase. Pex7p forms a beta-propeller structure and provides a platform for cooperative interactions with both the amphipathic PTS2 helix and Pex21p. The C-terminal region of Pex21p directly covers the hydrophobic surfaces of both Pex7p and PTS2, and the resulting hydrophobic core is the primary determinant of stable complex formation. Together with in vivo and in vitro functional assays of Pex7p and Pex21p variants, our findings reveal the molecular mechanism of PTS2 recognition.

	~~==Function==~~		Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p.,Pan D, Nakatsu T, Kato H Nat Struct Mol Biol. 2013 Aug;20(8):987-93. doi: 10.1038/nsmb.2618. Epub 2013 Jun, 30. PMID:23812376<ref>PMID:23812376</ref>
	~~[[http://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type~~ peroxisomal targeting signal ~~and plays an essential role in peroxisomal protein import essential for import of 3~~-~~oxoacyl~~-~~CoA thiolase~~ (~~a PTS2~~-~~containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes~~. ~~[[http~~:~~//www.uniprot~~.~~org/uniprot~~/~~PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2~~. ~~Required for peroxisomal targeting of PEX7 and growth on oleate~~. ~~Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA~~.~~<ref>~~PMID:~~9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref>~~ <ref>PMID:~~17451428~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3w15]] is a 3 chain structure with sequence from [http:/~~/~~en.wikipedia.org/wiki/ ]~~, ~~[http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii] and [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA].~~		</div>

	==See Also==		==See Also==
	*[[Thiolase\|Thiolase]]		*[[Thiolase\|Thiolase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:023812376</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Bionectria wenpingii]]		[[Category: Bionectria wenpingii]]
			[[Category: Ecoli]]
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Kato, H.]]		[[Category: Kato, H]]
	[[Category: Nakatsu, T.]]		[[Category: Nakatsu, T]]
	[[Category: Pan, D.]]		[[Category: Pan, D]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Cytosol]]		[[Category: Cytosol]]

OCA at 06:52, 16 October 2013

2013-10-16T06:52:40Z

← Older revision		Revision as of 06:52, 16 October 2013
Line 1:		Line 1:
	{{STRUCTURE_3w15\| PDB=3w15 \| SCENE= }}		{{STRUCTURE_3w15\| PDB=3w15 \| SCENE= }}
	===Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p===		===Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p===
			{{ABSTRACT_PUBMED_23812376}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
	[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA].		[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA].

			==See Also==
			*[[Thiolase\|Thiolase]]

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:023812376</ref><references group="xtra"/><references/>
			[[Category: Bionectria wenpingii]]
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Kato, H.]]		[[Category: Kato, H.]]

OCA at 14:12, 3 July 2013

2013-07-03T14:12:14Z

← Older revision		Revision as of 14:12, 3 July 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_3w15\| PDB=3w15 \| SCENE= }}
			===Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p===

	~~The entry 3w15 is ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/PEX7_YEAST PEX7_YEAST]] Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. [[http://www.uniprot.org/uniprot/PEX21_YEAST PEX21_YEAST]] Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA.<ref>PMID:9864360</ref> <ref>PMID:12204379</ref> <ref>PMID:12167700</ref> <ref>PMID:17451428</ref>

	~~Authors~~: ~~Pan, D~~.~~, Nakatsu, T~~.~~, Kato, H~~.		==About this Structure==
			[[3w15]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W15 OCA].

	~~Description~~: ~~A peroxin complex~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Saccharomyces cerevisiae s288c]]
			[[Category: Kato, H.]]
			[[Category: Nakatsu, T.]]
			[[Category: Pan, D.]]
			[[Category: Beta-propeller]]
			[[Category: Cytosol]]
			[[Category: Peroxisome]]
			[[Category: Protein transport]]
			[[Category: Targeting signal recognition]]

OCA at 09:36, 13 March 2013

2013-03-13T09:36:53Z

← Older revision		Revision as of 09:36, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3w15 is ON HOLD		The entry 3w15 is ON HOLD until Paper Publication

	Authors: Pan, D., Nakatsu, T., Kato, H.		Authors: Pan, D., Nakatsu, T., Kato, H.

	Description: A peroxin complex		Description: A peroxin complex

OCA: Protected "3w15" [edit=sysop:move=sysop]

2012-11-14T06:05:43Z

Protected "3w15" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:05, 14 November 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3w15 is ON HOLD Authors: Pan, D., Nakatsu, T., Kato, H. Description: A peroxin complex

2012-11-14T06:05:42Z

New page: '''Unreleased structure''' The entry 3w15 is ON HOLD Authors: Pan, D., Nakatsu, T., Kato, H. Description: A peroxin complex

New page

'''Unreleased structure'''

The entry 3w15 is ON HOLD

Authors: Pan, D., Nakatsu, T., Kato, H.

Description: A peroxin complex