3wpf - Revision history

OCA at 13:20, 8 November 2023

2023-11-08T13:20:17Z

← Older revision		Revision as of 13:20, 8 November 2023
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	<StructureSection load='3wpf' size='340' side='right'caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3wpf' size='340' side='right'caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WPF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N-ACETYL-D~~-~~GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.959Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Tlr9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [https://pdbe.org/3wpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [https://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [https://pdbe.org/3wpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [https://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>		[https://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Ohto, U]]		[[Category: Ohto U]]
	[[Category: Shimizu, T]]		[[Category: Shimizu T]]
	~~[[Category: Dna binding]]~~
	~~[[Category: Dna binding protein]]~~
	~~[[Category: Glycosylation]]~~
	~~[[Category: Innate immunity]]~~
	~~[[Category: Leucine rich repeat]]~~
	~~[[Category: Receptor~~]]

OCA at 05:45, 3 August 2022

2022-08-03T05:45:15Z

← Older revision		Revision as of 05:45, 3 August 2022
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	==Crystal structure of mouse TLR9 (unliganded form)==		==Crystal structure of mouse TLR9 (unliganded form)==
	<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3wpf' size='340' side='right'caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WPF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tlr9 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tlr9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [~~http~~://pdbe.org/3wpf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [https://pdbe.org/3wpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [https://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>		[[https://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Toll-like ~~Receptors~~\|Toll-like ~~Receptors~~]]		*[[Toll-like Receptor 3D structures\|Toll-like Receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ohto, U]]		[[Category: Ohto, U]]

OCA at 09:44, 21 February 2019

2019-02-21T09:44:36Z

← Older revision		Revision as of 09:44, 21 February 2019
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	<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tlr9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [http://pdbe.org/3wpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [http://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [http://pdbe.org/3wpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [http://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Lk3 transgenic mice]]
	[[Category: Ohto, U]]		[[Category: Ohto, U]]
	[[Category: Shimizu, T]]		[[Category: Shimizu, T]]

OCA at 17:36, 9 March 2017

2017-03-09T17:36:04Z

← Older revision		Revision as of 17:36, 9 March 2017
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	==Crystal structure of mouse TLR9 (unliganded form)==		==Crystal structure of mouse TLR9 (unliganded form)==
	<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [http://www.ebi.ac.uk/pdbsum/3wpf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [http://pdbe.org/3wpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [http://www.ebi.ac.uk/pdbsum/3wpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3wpf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Toll-like Receptors\|Toll-like Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 6 May 2015

2015-05-06T07:29:39Z

← Older revision		Revision as of 07:29, 6 May 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>		[[http://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Innate immunity serves as the first line of defence against invading pathogens such as bacteria and viruses. Toll-like receptors (TLRs) are examples of innate immune receptors, which sense specific molecular patterns from pathogens and activate immune responses. TLR9 recognizes bacterial and viral DNA containing the cytosine-phosphate-guanine (CpG) dideoxynucleotide motif. The molecular basis by which CpG-containing DNA (CpG-DNA) elicits immunostimulatory activity via TLR9 remains to be elucidated. Here we show the crystal structures of three forms of TLR9: unliganded, bound to agonistic CpG-DNA, and bound to inhibitory DNA (iDNA). Agonistic-CpG-DNA-bound TLR9 formed a symmetric TLR9-CpG-DNA complex with 2:2 stoichiometry, whereas iDNA-bound TLR9 was a monomer. CpG-DNA was recognized by both protomers in the dimer, in particular by the amino-terminal fragment (LRRNT-LRR10) from one protomer and the carboxy-terminal fragment (LRR20-LRR22) from the other. The iDNA, which formed a stem-loop structure suitable for binding by intramolecular base pairing, bound to the concave surface from LRR2-LRR10. This structure serves as an important basis for improving our understanding of the functional mechanisms of TLR9.

			Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.,Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T Nature. 2015 Apr 30;520(7549):702-5. doi: 10.1038/nature14138. Epub 2015 Feb 9. PMID:25686612<ref>PMID:25686612</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:55, 12 February 2015

2015-02-12T11:55:57Z

← Older revision		Revision as of 11:55, 12 February 2015
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	'''~~Unreleased structure~~'''		==Crystal structure of mouse TLR9 (unliganded form)==
			<StructureSection load='3wpf' size='340' side='right' caption='[[3wpf]], [[Resolution\|resolution]] 1.96Å' scene=''>
	~~The entry~~ 3wpf is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3wpf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPF FirstGlance]. <br>
	~~Authors~~: ~~Ohto~~, U., ~~Shimizu~~, T.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wpb\|3wpb]], [[3wpc\|3wpc]], [[3wpd\|3wpd]], [[3wpe\|3wpe]], [[3wpg\|3wpg]], [[3wph\|3wph]], [[3wpi\|3wpi]]</td></tr>
	~~Description~~: ~~Crystal structure~~ of ~~mouse~~ TLR9 (~~unliganded form~~)		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wpf RCSB], [http://www.ebi.ac.uk/pdbsum/3wpf PDBsum]</span></td></tr>
	~~[[Category: Unreleased Structures]]~~		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Ohto, U]]		[[Category: Ohto, U]]
	[[Category: Shimizu, T]]		[[Category: Shimizu, T]]
			[[Category: Dna binding]]
			[[Category: Dna binding protein]]
			[[Category: Glycosylation]]
			[[Category: Innate immunity]]
			[[Category: Leucine rich repeat]]
			[[Category: Receptor]]

OCA at 12:48, 24 December 2014

2014-12-24T12:48:05Z

← Older revision		Revision as of 12:48, 24 December 2014
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	Description: Crystal structure of mouse TLR9 (unliganded form)		Description: Crystal structure of mouse TLR9 (unliganded form)
			[[Category: Unreleased Structures]]
			[[Category: Ohto, U]]
			[[Category: Shimizu, T]]

OCA at 07:15, 7 May 2014

2014-05-07T07:15:16Z

← Older revision		Revision as of 07:15, 7 May 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3wpf is ON HOLD		The entry 3wpf is ON HOLD until Paper Publication

	Authors: Ohto, U., Shimizu, T.		Authors: Ohto, U., Shimizu, T.

	Description: Crystal structure of mouse TLR9 (unliganded form)		Description: Crystal structure of mouse TLR9 (unliganded form)

OCA: Protected "3wpf" [edit=sysop:move=sysop]

2014-01-22T06:38:24Z

Protected "3wpf" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:38, 22 January 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 3wpf is ON HOLD Authors: Ohto, U., Shimizu, T. Description: Crystal structure of mouse TLR9 (unliganded form)

2014-01-22T06:38:23Z

New page: '''Unreleased structure''' The entry 3wpf is ON HOLD Authors: Ohto, U., Shimizu, T. Description: Crystal structure of mouse TLR9 (unliganded form)

New page

'''Unreleased structure'''

The entry 3wpf is ON HOLD

Authors: Ohto, U., Shimizu, T.

Description: Crystal structure of mouse TLR9 (unliganded form)