3zos - Revision history

OCA at 11:08, 20 December 2023

2023-12-20T11:08:43Z

← Older revision		Revision as of 11:08, 20 December 2023
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	<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [https://pdbe.org/3zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [https://www.ebi.ac.uk/pdbsum/3zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [https://pdbe.org/3zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [https://www.ebi.ac.uk/pdbsum/3zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Receptor protein-tyrosine kinase]]~~		[[Category: Arrowsmith CH]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Bountra C]]
	[[Category: Bountra, C]]		[[Category: Bradley A]]
	[[Category: Bradley, A]]		[[Category: Bullock A]]
	[[Category: Bullock, A]]		[[Category: Canning P]]
	[[Category: Canning, P]]		[[Category: Coutandin D]]
	[[Category: Coutandin, D]]		[[Category: Edwards AM]]
	~~[[Category: Delft, F von~~]]		[[Category: Elkins JM]]
	[[Category: Edwards~~, A M~~]]		[[Category: Goubin S]]
	[[Category: Elkins~~, J M~~]]		[[Category: Mahajan P]]
	[[Category: Goubin, S]]		[[Category: Von Delft F]]
	[[Category: Mahajan, P]]
	[[Category: ~~Collagen]]~~
	~~[[Category: Discoidin domain]]~~
	~~[[Category: Rtk]]~~
	~~[[Category: Transferase~~]]

OCA at 07:06, 18 August 2022

2022-08-18T07:06:11Z

← Older revision		Revision as of 07:06, 18 August 2022
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	<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [~~http~~://pdbe.org/3zos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [https://pdbe.org/3zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [https://www.ebi.ac.uk/pdbsum/3zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:55, 1 January 2020

2020-01-01T12:55:59Z

← Older revision		Revision as of 12:55, 1 January 2020
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	==Structure of the DDR1 kinase domain in complex with ponatinib==		==Structure of the DDR1 kinase domain in complex with ponatinib==
	<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right'caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 3zos" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zos" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Epithelial discoidin domain-containing receptor\|Epithelial discoidin domain-containing receptor]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 19:43, 24 January 2018

2018-01-24T19:43:41Z

← Older revision		Revision as of 19:43, 24 January 2018
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	==~~Crystal structure~~ of the ~~human~~ DDR1 kinase domain==		==Structure of the DDR1 kinase domain in complex with ponatinib==
	<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 18:54, 11 August 2016

2016-08-11T18:54:45Z

← Older revision		Revision as of 18:54, 11 August 2016
Line 1:		Line 1:

	==Crystal structure of the human DDR1 kinase domain==		==Crystal structure of the human DDR1 kinase domain==
	<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://pdbe.org/3zos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zos ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3zos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:30, 4 January 2015

2015-01-04T10:30:05Z

← Older revision		Revision as of 10:30, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Human]]		[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Bradley, A.]]		[[Category: Bradley, A]]
	[[Category: Bullock, A.]]		[[Category: Bullock, A]]
	[[Category: Canning, P.]]		[[Category: Canning, P]]
	[[Category: Coutandin, D.]]		[[Category: Coutandin, D]]
	[[Category: Delft, F von.]]		[[Category: Delft, F von]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Elkins, J M.]]		[[Category: Elkins, J M]]
	[[Category: Goubin, S.]]		[[Category: Goubin, S]]
	[[Category: Mahajan, P.]]		[[Category: Mahajan, P]]
	[[Category: Collagen]]		[[Category: Collagen]]
	[[Category: Discoidin domain]]		[[Category: Discoidin domain]]
	[[Category: Rtk]]		[[Category: Rtk]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:23, 18 June 2014

2014-06-18T05:23:47Z

← Older revision		Revision as of 05:23, 18 June 2014
Line 2:		Line 2:
	<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. <br>		<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZOS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>
	<table>		<table>
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	Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>		Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 06:47, 7 May 2014

2014-05-07T06:47:15Z

← Older revision		Revision as of 06:47, 7 May 2014
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	~~{{STRUCTURE_3zos~~\| ~~PDB~~=3zos \| ~~SCENE~~= }}		==Crystal structure of the human DDR1 kinase domain==
	===~~Crystal structure~~ of the human DDR1 kinase domain~~===~~		<StructureSection load='3zos' size='340' side='right' caption='[[3zos]], [[Resolution\|resolution]] 1.92Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LI:3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE'>0LI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zos RCSB], [http://www.ebi.ac.uk/pdbsum/3zos PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The discoidin domain receptors, DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclerosis and cancer. We report the inhibition of these unusual receptor tyrosine kinases by the multi-targeted cancer drugs imatinib and ponatinib as well as the selective type II inhibitor DDR1-IN-1. Ponatinib is identified as the more potent molecule, which inhibits DDR1 and DDR2 with an IC50 of 9 nM. Co-crystal structures of human DDR1 reveal a DFG-out conformation of the kinase domain that is stabilized by an unusual salt bridge between the activation loop and alphaD helix. Differences to Abelson kinase (ABL) are observed in the DDR1 P-loop, where a beta-hairpin replaces the cage-like structure of ABL. P-loop residues in DDR1 that confer drug resistance in ABL are therefore accommodated outside the ATP pocket. Whereas imatinib and ponatinib bind potently to both the DDR and ABL kinases, the hydrophobic interactions of the ABL P-loop appear poorly satisfied by DDR1-IN-1 suggesting a structural basis for its DDR1 selectivity. Such inhibitors may have applications in clinical indications of DDR1 and DDR2 overexpression or mutation, including lung cancer.

	~~==About this Structure==~~		Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>
	~~[[3zos]] is a 2 chain structure with sequence from [http~~:/~~/en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort?id=3ZOS OCA].~~
			From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]

OCA at 06:14, 23 April 2014

2014-04-23T06:14:53Z

← Older revision		Revision as of 06:14, 23 April 2014
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	==About this Structure==		==About this Structure==
	[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA].		[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA].
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA at 07:45, 2 May 2013

2013-05-02T07:45:22Z

← Older revision		Revision as of 07:45, 2 May 2013
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	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_3zos\| PDB=3zos \| SCENE= }}
			===Crystal structure of the human DDR1 kinase domain===

	~~The entry~~ 3zos is ~~ON HOLD~~		==About this Structure==
			[[3zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZOS OCA].
	~~Authors~~: ~~Canning~~, P., ~~Elkins~~, ~~J.M~~., ~~Goubin, S~~.~~, Mahajan~~, P.~~, Bradley, A.,~~ Coutandin, D.~~, von~~ Delft, F.~~, Arrowsmith, C.H.,~~ Edwards, A.M., ~~Bountra, C~~., ~~Bullock, A~~.		[[Category: Homo sapiens]]
			[[Category: Receptor protein-tyrosine kinase]]
	~~Description~~: ~~Crystal structure of the human DDR1 kinase~~ domain		[[Category: Arrowsmith, C H.]]
			[[Category: Bountra, C.]]
			[[Category: Bradley, A.]]
			[[Category: Bullock, A.]]
			[[Category: Canning, P.]]
			[[Category: Coutandin, D.]]
			[[Category: Delft, F von.]]
			[[Category: Edwards, A M.]]
			[[Category: Elkins, J M.]]
			[[Category: Goubin, S.]]
			[[Category: Mahajan, P.]]
			[[Category: Collagen]]
			[[Category: Discoidin domain]]
			[[Category: Rtk]]
			[[Category: Transferase]]