4a4e - Revision history

OCA at 06:00, 19 June 2024

2024-06-19T06:00:10Z

← Older revision		Revision as of 06:00, 19 June 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [https://pdbe.org/4a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [https://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [https://pdbe.org/4a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [https://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:07, 14 June 2023

2023-06-14T10:07:29Z

← Older revision		Revision as of 10:07, 14 June 2023
Line 1:		Line 1:

	==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==		==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==
	<StructureSection load='4a4e' size='340' side='right'caption='[[4a4e~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='4a4e' size='340' side='right'caption='[[4a4e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [https://pdbe.org/4a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [https://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [https://pdbe.org/4a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [https://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/SMN_HUMAN SMN_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Englbrecht, C]]		[[Category: Englbrecht C]]
	[[Category: Fessas, D]]		[[Category: Fessas D]]
	[[Category: Fischer, U]]		[[Category: Fischer U]]
	[[Category: Machyna, M]]		[[Category: Machyna M]]
	[[Category: Madl, T]]		[[Category: Madl T]]
	[[Category: Neugebauer~~, K M~~]]		[[Category: Neugebauer KM]]
	[[Category: Sattler, M]]		[[Category: Sattler M]]
	[[Category: Tripsianes, K]]		[[Category: Tripsianes K]]
	~~[[Category: Rna binding protein~~]]

OCA at 07:44, 18 August 2022

2022-08-18T07:44:23Z

← Older revision		Revision as of 07:44, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a4e' size='340' side='right'caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4a4e' size='340' side='right'caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [~~http~~://pdbe.org/4a4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [https://pdbe.org/4a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [https://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Englbrecht, C]]		[[Category: Englbrecht, C]]
	[[Category: Fessas, D]]		[[Category: Fessas, D]]

OCA at 09:40, 6 March 2019

2019-03-06T09:40:59Z

← Older revision		Revision as of 09:40, 6 March 2019
Line 1:		Line 1:

	==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==		==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==
	<StructureSection load='4a4e' size='340' side='right' caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4a4e' size='340' side='right'caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>

OCA at 19:58, 4 August 2016

2016-08-04T19:58:57Z

← Older revision		Revision as of 19:58, 4 August 2016
Line 1:		Line 1:

	==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==		==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==
	<StructureSection load='4a4e' size='340' side='right' caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4a4e' size='340' side='right' caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [http://www.ebi.ac.uk/pdbsum/4a4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [http://pdbe.org/4a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [http://www.ebi.ac.uk/pdbsum/4a4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4a4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Englbrecht, C]]		[[Category: Englbrecht, C]]
	[[Category: Fessas, D]]		[[Category: Fessas, D]]

OCA at 12:38, 25 December 2014

2014-12-25T12:38:55Z

← Older revision		Revision as of 12:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [http://www.ebi.ac.uk/pdbsum/4a4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [http://www.ebi.ac.uk/pdbsum/4a4e PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Englbrecht, C.]]		[[Category: Englbrecht, C]]
	[[Category: Fessas, D.]]		[[Category: Fessas, D]]
	[[Category: Fischer, U.]]		[[Category: Fischer, U]]
	[[Category: Machyna, M.]]		[[Category: Machyna, M]]
	[[Category: Madl, T.]]		[[Category: Madl, T]]
	[[Category: Neugebauer, K M.]]		[[Category: Neugebauer, K M]]
	[[Category: Sattler, M.]]		[[Category: Sattler, M]]
	[[Category: Tripsianes, K.]]		[[Category: Tripsianes, K]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 08:34, 5 June 2014

2014-06-05T08:34:11Z

← Older revision		Revision as of 08:34, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4a4e~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine==
			<StructureSection load='4a4e' size='340' side='right' caption='[[4a4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g5v\|1g5v]], [[1mhn\|1mhn]], [[4a4g\|4a4g]], [[4a4f\|4a4f]], [[4a4h\|4a4h]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a4e RCSB], [http://www.ebi.ac.uk/pdbsum/4a4e PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Arginine dimethylation plays critical roles in the assembly of ribonucleoprotein complexes in pre-mRNA splicing and piRNA pathways. We report solution structures of SMN and SPF30 Tudor domains bound to symmetric and asymmetric dimethylated arginine (DMA) that is inherent in the RNP complexes. An aromatic cage in the Tudor domain mediates dimethylarginine recognition by electrostatic stabilization through cation-pi interactions. Distinct from extended Tudor domains, dimethylarginine binding by the SMN and SPF30 Tudor domains is independent of proximal residues in the ligand. Yet, enhanced micromolar affinities are obtained by external cooperativity when multiple methylation marks are presented in arginine- and glycine-rich peptide ligands. A hydrogen bond network in the SMN Tudor domain, including Glu134 and a tyrosine hydroxyl of the aromatic cage, enhances cation-pi interactions and is impaired by a mutation causing an E134K substitution associated with spinal muscular atrophy. Our structural analysis enables the design of an optimized binding pocket and the prediction of DMA binding properties of Tudor domains.

	~~<!--~~		Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.,Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M Nat Struct Mol Biol. 2011 Nov 20. doi: 10.1038/nsmb.2185. PMID:22101937<ref>PMID:22101937</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a4e"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_4a4e\| PDB=4a4e \| SCENE= }}~~

	~~===Solution structure~~ of ~~SMN Tudor domain in complex with symmetrically dimethylated arginine===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22101937}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22101937 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22101937}}~~

	~~==About this Structure==~~
	~~[[4a4e]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4E OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022101937<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Englbrecht, C.]]		[[Category: Englbrecht, C.]]

OCA at 06:21, 28 December 2011

2011-12-28T06:21:47Z

← Older revision		Revision as of 06:21, 28 December 2011
Line 9:		Line 9:
	{{STRUCTURE_4a4e\| PDB=4a4e \| SCENE= }}		{{STRUCTURE_4a4e\| PDB=4a4e \| SCENE= }}

	===~~SOLUTION STRUCTURE OF~~ SMN ~~TUDOR DOMAIN IN COMPLEX WITH SYMMETRICALLY DIMETHYLATED ARGININE~~===		===Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine===

OCA at 08:13, 7 December 2011

2011-12-07T08:13:36Z

← Older revision		Revision as of 08:13, 7 December 2011
Line 1:		Line 1:
	[[Image:4a4e.~~jpg~~\|left\|200px]]		[[Image:4a4e.png\|left\|200px]]

	<!--		<!--

OCA at 06:20, 30 November 2011

2011-11-30T06:20:26Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4a4e.jpg|left|200px]]
-The entry 4a4e is ON HOLD  until Paper Publication
+<!--
-Authors: Tripsianes, K., Madl, T., Machyna, M., Fessas, D., Englbrecht, C., Fischer, U., Neugebauer, K.M., Sattler, M.
+===SOLUTION STRUCTURE OF SMN TUDOR DOMAIN IN COMPLEX WITH SYMMETRICALLY DIMETHYLATED ARGININE===
-Description: Solution structure of SMN Tudor domain in complex with symmetrically dimethylated arginine