4a67 - Revision history

OCA at 11:20, 20 December 2023

2023-12-20T11:20:19Z

← Older revision		Revision as of 11:20, 20 December 2023
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	<StructureSection load='4a67' size='340' side='right'caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4a67' size='340' side='right'caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A67 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></~~td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'~~>~~[[1uvw\|1uvw]]~~, ~~[[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]~~<~~/div></td></tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [https://pdbe.org/4a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [https://www.ebi.ac.uk/pdbsum/4a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [https://pdbe.org/4a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [https://www.ebi.ac.uk/pdbsum/4a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.		[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU] Involved in brown pigmentation during sporogenesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835]]~~		[[Category: Bacillus subtilis]]
	~~[[Category: Laccase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bento, I]]		[[Category: Bento I]]
	[[Category: Lindley~~, P F~~]]		[[Category: Lindley PF]]
	[[Category: Silva~~, C S]]~~		[[Category: Silva CS]]
	~~[[Category: Dioxygen reduction]]~~
	~~[[Category: Multi-copper oxidase]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Oxidoreductase activity]]~~
	~~[[Category: Trinuclear cluster~~]]

OCA at 07:47, 18 August 2022

2022-08-18T07:47:51Z

← Older revision		Revision as of 07:47, 18 August 2022
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	<StructureSection load='4a67' size='340' side='right'caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4a67' size='340' side='right'caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Laccase Laccase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [~~http~~://pdbe.org/4a67 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a67 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [https://pdbe.org/4a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [https://www.ebi.ac.uk/pdbsum/4a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.		[[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
	*[[~~CotA laccase~~\|~~CotA laccase~~]]		*[[Laccase 3D structures\|Laccase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Laccase]]		[[Category: Laccase]]
			[[Category: Large Structures]]
	[[Category: Bento, I]]		[[Category: Bento, I]]
	[[Category: Lindley, P F]]		[[Category: Lindley, P F]]

OCA at 08:56, 6 March 2019

2019-03-06T08:56:26Z

← Older revision		Revision as of 08:56, 6 March 2019
Line 1:		Line 1:

	==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant==		==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant==
	<StructureSection load='4a67' size='340' side='right' caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4a67' size='340' side='right'caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus globigii migula 1900~~]]		[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Bento, I]]		[[Category: Bento, I]]

OCA at 12:21, 4 August 2016

2016-08-04T12:21:20Z

← Older revision		Revision as of 12:21, 4 August 2016
Line 1:		Line 1:

	==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant==		==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant==
	<StructureSection load='4a67' size='340' side='right' caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4a67' size='340' side='right' caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [http://www.ebi.ac.uk/pdbsum/4a67 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [http://pdbe.org/4a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [http://www.ebi.ac.uk/pdbsum/4a67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4a67" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Bacillus ~~subtilis~~]]		[[Category: Bacillus globigii migula 1900]]
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Bento, I]]		[[Category: Bento, I]]

OCA at 09:15, 25 December 2014

2014-12-25T09:15:29Z

← Older revision		Revision as of 09:15, 25 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4a67~~.~~png~~\|~~left~~\|~~200px~~]]		==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant==
			<StructureSection load='4a67' size='340' side='right' caption='[[4a67]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A67 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a68\|4a68]], [[1w8e\|1w8e]], [[4a66\|4a66]], [[1gsk\|1gsk]], [[1w6l\|1w6l]], [[2x87\|2x87]], [[2bhf\|2bhf]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a67 RCSB], [http://www.ebi.ac.uk/pdbsum/4a67 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Multi-copper oxidases constitute a family of proteins that are capable of coupling the one-electron oxidation of four substrate equivalents to the four-electron reduction of dioxygen to two molecules of water. The main catalytic stages occurring during the process have already been identified, but several questions remain, including the nature of the protonation events that take place during the reductive cleavage of dioxygen to water. The presence of a structurally conserved acidic residue (Glu498 in CotA laccase from Bacillus subtilis) at the dioxygen-entrance channel has been reported to play a decisive role in the protonation mechanisms, channelling protons during the reduction process and stabilizing the site as a whole. A second acidic residue that is sequentially conserved in multi-copper oxidases and sited within the exit channel (Asp116 in CotA) has also been identified as being important in the protonation process. In this study, CotA laccase has been used as a model system to assess the role of Asp116 in the reduction process of dioxygen to water. The crystal structures of three distinct mutants, D116E, D116N and D116A, produced by site-saturation mutagenesis have been determined. In addition, theoretical calculations have provided further support for a role of this residue in the protonation events.

	~~{{STRUCTURE_4a67\| PDB=4a67 \| SCENE= }}~~		The role of Asp116 in the reductive cleavage of dioxygen to water in CotA laccase: assistance during the proton-transfer mechanism.,Silva CS, Damas JM, Chen Z, Brissos V, Martins LO, Soares CM, Lindley PF, Bento I Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):186-93. Epub 2012 Jan 17. PMID:22281748<ref>PMID:22281748</ref>

	~~===Mutations in~~ the ~~neighbourhood~~ of ~~CotA-laccase trinuclear site: D116E mutant===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_22281748}}~~		==See Also==
			*[[CotA laccase\|CotA laccase]]
	==~~About this Structure~~==		== References ==
	[[~~4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:022281748<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Bento, I.]]		[[Category: Bento, I]]
	[[Category: Lindley, P F.]]		[[Category: Lindley, P F]]
	[[Category: Silva, C S.]]		[[Category: Silva, C S]]
	[[Category: Dioxygen reduction]]		[[Category: Dioxygen reduction]]
	[[Category: Multi-copper oxidase]]		[[Category: Multi-copper oxidase]]

OCA at 09:51, 21 October 2012

2012-10-21T09:51:40Z

← Older revision		Revision as of 09:51, 21 October 2012
Line 9:		Line 9:
	==About this Structure==		==About this Structure==
	[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].		[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].

	~~==See Also==~~
	*[[Spore coat protein\|Spore coat protein]]

	==Reference==		==Reference==

OCA at 14:59, 20 October 2012

2012-10-20T14:59:52Z

← Older revision		Revision as of 14:59, 20 October 2012
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	[[Image:4a67.png\|left\|200px]]		[[Image:4a67.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_4a67", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_4a67\| PDB=4a67 \| SCENE= }}		{{STRUCTURE_4a67\| PDB=4a67 \| SCENE= }}

	===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant===		===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22281748}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 22281748 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_22281748}}		{{ABSTRACT_PUBMED_22281748}}

	==About this Structure==		==About this Structure==
	[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].		[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].

			==See Also==
			*[[Spore coat protein\|Spore coat protein]]

	==Reference==		==Reference==

OCA at 06:42, 28 March 2012

2012-03-28T06:42:45Z

← Older revision		Revision as of 06:42, 28 March 2012
Line 11:		Line 11:
	===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant===		===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22281748}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22281748 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22281748}}

	==About this Structure==		==About this Structure==
	[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].		[[4a67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A67 OCA].

			==Reference==
			<ref group="xtra">PMID:022281748</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Laccase]]		[[Category: Laccase]]

OCA at 07:33, 1 February 2012

2012-02-01T07:33:44Z

← Older revision		Revision as of 07:33, 1 February 2012
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	[[Image:4a67.~~jpg~~\|left\|200px]]		[[Image:4a67.png\|left\|200px]]

	<!--		<!--

OCA at 06:51, 25 January 2012

2012-01-25T06:51:19Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4a67.jpg|left|200px]]
-The entry 4a67 is ON HOLD  until Paper Publication
+<!--
-Authors: Silva, C.S., Lindley, P.F., Bento, I.
+===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant===
-Description: Mutations in the neighbourhood of CotA-laccase trinuclear site: D116E mutant