4aaa - Revision history

OCA at 11:22, 20 December 2023

2023-12-20T11:22:50Z

← Older revision		Revision as of 11:22, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4aaa' size='340' side='right'caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='4aaa' size='340' side='right'caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [https://pdbe.org/4aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [https://www.ebi.ac.uk/pdbsum/4aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aaa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [https://pdbe.org/4aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [https://www.ebi.ac.uk/pdbsum/4aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aaa ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CDKL2_HUMAN CDKL2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Cyclin-dependent kinase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Arrowsmith CH]]
	[[Category: Berridge, G]]		[[Category: Berridge G]]
	[[Category: Bountra, C]]		[[Category: Bountra C]]
	[[Category: Bullock, A]]		[[Category: Bullock A]]
	[[Category: Burgess-Brown, N]]		[[Category: Burgess-Brown N]]
	[[Category: Canning, P]]		[[Category: Canning P]]
	[[Category: Cooper~~, C D.O~~]]		[[Category: Cooper CDO]]
	[[Category: Daga, N]]		[[Category: Daga N]]
	~~[[Category: Delft, F von~~]]		[[Category: Edwards AM]]
	[[Category: Edwards~~, A M~~]]		[[Category: Krojer T]]
	[[Category: Krojer, T]]		[[Category: Mahajan P]]
	[[Category: Mahajan, P]]		[[Category: Muniz JRC]]
	[[Category: Muniz~~, J R.C~~]]		[[Category: Vollmar M]]
	[[Category: Vollmar, M]]		[[Category: Weigelt J]]
	[[Category: Weigelt, J]]		[[Category: Von Delft F]]
	[[Category: ~~Phospho-mimetic]]~~
	~~[[Category: Transferase~~]]

OCA at 10:50, 30 March 2022

2022-03-30T10:50:19Z

← Older revision		Revision as of 10:50, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='4aaa' size='340' side='right'caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='4aaa' size='340' side='right'caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [~~http~~://pdbe.org/4aaa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aaa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aaa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [https://pdbe.org/4aaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [https://www.ebi.ac.uk/pdbsum/4aaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aaa ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have similar functions. Here, we present the crystal structures of human CDKL1, CDKL2, CDKL3, and CDKL5, revealing their evolutionary divergence from CDK and mitogen-activated protein kinases (MAPKs), including an unusual ?J helix important for CDKL2 and CDKL3 activity. C. elegans CDKL-1, most closely related to CDKL1-4 and localized to neuronal cilia transition zones, modulates cilium length; this depends on its kinase activity and ?J helix-containing C terminus. Human CDKL5, linked to Rett syndrome, also localizes to cilia, and it impairs ciliogenesis when overexpressed. CDKL5 patient mutations modeled in CDKL-1 cause localization and/or cilium length defects. Together, our studies establish a disease model system suggesting cilium length defects as a pathomechanism for neurological disorders, including epilepsy.

			CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.,Canning P, Park K, Goncalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR Cell Rep. 2018 Jan 23;22(4):885-894. doi: 10.1016/j.celrep.2017.12.083. Epub 2018, Jan 28. PMID:29420175<ref>PMID:29420175</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4aaa" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:04, 1 January 2020

2020-01-01T13:04:16Z

← Older revision		Revision as of 13:04, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of the human CDKL2 kinase domain==		==Crystal structure of the human CDKL2 kinase domain==
	<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='4aaa' size='340' side='right'caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
Line 12:		Line 12:
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berridge, G]]		[[Category: Berridge, G]]

OCA at 19:44, 24 January 2018

2018-01-24T19:44:49Z

← Older revision		Revision as of 19:44, 24 January 2018
Line 1:		Line 1:

	==~~CRYSTAL STRUCTURE OF THE HUMAN~~ CDKL2 ~~KINASE DOMAIN~~==		==Crystal structure of the human CDKL2 kinase domain==
	<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 20:		Line 20:
	[[Category: Cooper, C D.O]]		[[Category: Cooper, C D.O]]
	[[Category: Daga, N]]		[[Category: Daga, N]]
	[[Category: Delft, F ~~Von~~]]		[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]

OCA at 07:38, 11 August 2016

2016-08-11T07:38:20Z

← Older revision		Revision as of 07:38, 11 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN==		==CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN==
	<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [http://www.ebi.ac.uk/pdbsum/4aaa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [http://pdbe.org/4aaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [http://www.ebi.ac.uk/pdbsum/4aaa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aaa ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berridge, G]]		[[Category: Berridge, G]]

OCA at 09:40, 4 January 2015

2015-01-04T09:40:04Z

← Older revision		Revision as of 09:40, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [http://www.ebi.ac.uk/pdbsum/4aaa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [http://www.ebi.ac.uk/pdbsum/4aaa PDBsum]</span></td></tr>
	<table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Berridge, G.]]		[[Category: Berridge, G]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Bullock, A.]]		[[Category: Bullock, A]]
	[[Category: Burgess-Brown, N.]]		[[Category: Burgess-Brown, N]]
	[[Category: Canning, P.]]		[[Category: Canning, P]]
	[[Category: Cooper, C D.O.]]		[[Category: Cooper, C D.O]]
	[[Category: Daga, N.]]		[[Category: Daga, N]]
	[[Category: Delft, F Von.]]		[[Category: Delft, F Von]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Krojer, T.]]		[[Category: Krojer, T]]
	[[Category: Mahajan, P.]]		[[Category: Mahajan, P]]
	[[Category: Muniz, J R.C.]]		[[Category: Muniz, J R.C]]
	[[Category: Vollmar, M.]]		[[Category: Vollmar, M]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Phospho-mimetic]]		[[Category: Phospho-mimetic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:47, 5 June 2014

2014-06-05T07:47:32Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN==
+<StructureSection load='4aaa' size='340' side='right' caption='[[4aaa]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-The entry 4aaa is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4aaa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAA FirstGlance]. <br>
-Authors: Canning, P., Vollmar, M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., Von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-Description: Crystal structure of the human CDKL2 kinase domain
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aaa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aaa RCSB], [http://www.ebi.ac.uk/pdbsum/4aaa PDBsum]</span></td></tr>

OCA: Protected "4aaa" [edit=sysop:move=sysop]

2011-12-07T07:45:54Z

Protected "4aaa" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:45, 7 December 2011
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4aaa is ON HOLD Authors: Canning, P., Vollmar, M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T....

2011-12-07T07:45:53Z

New page: '''Unreleased structure''' The entry 4aaa is ON HOLD Authors: Canning, P., Vollmar, M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T....

New page

'''Unreleased structure'''

The entry 4aaa is ON HOLD

Authors: Canning, P., Vollmar, M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., Von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

Description: Crystal structure of the human CDKL2 kinase domain