4alg - Revision history

OCA at 10:51, 9 May 2024

2024-05-09T10:51:47Z

← Older revision		Revision as of 10:51, 9 May 2024
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	<StructureSection load='4alg' size='340' side='right'caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4alg' size='340' side='right'caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [https://pdbe.org/4alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [https://www.ebi.ac.uk/pdbsum/4alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4alg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [https://pdbe.org/4alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [https://www.ebi.ac.uk/pdbsum/4alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4alg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>		[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bouillot, A]]		[[Category: Bouillot A]]
	[[Category: Chung, C]]		[[Category: Chung C]]
	[[Category: Donche, F]]		[[Category: Donche F]]
	[[Category: Lamotte, Y]]		[[Category: Lamotte Y]]
	[[Category: Mirguet, O]]		[[Category: Mirguet O]]
	~~[[Category: Epigenetic reader]]~~
	~~[[Category: Histone]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Signaling protein~~]]

OCA at 05:38, 25 August 2022

2022-08-25T05:38:02Z

← Older revision		Revision as of 05:38, 25 August 2022
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	<StructureSection load='4alg' size='340' side='right'caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4alg' size='340' side='right'caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [~~http~~://pdbe.org/4alg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4alg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4alg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [https://pdbe.org/4alg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [https://www.ebi.ac.uk/pdbsum/4alg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4alg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>		[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:55, 21 May 2019

2019-05-21T07:55:29Z

← Older revision		Revision as of 07:55, 21 May 2019
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]		*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bouillot, A]]		[[Category: Bouillot, A]]
	[[Category: Chung, C]]		[[Category: Chung, C]]

OCA at 09:20, 6 March 2019

2019-03-06T09:20:29Z

← Older revision		Revision as of 09:20, 6 March 2019
Line 1:		Line 1:

	==N-Terminal Bromodomain of Human BRD2 With IBET-151==		==N-Terminal Bromodomain of Human BRD2 With IBET-151==
	<StructureSection load='4alg' size='340' side='right' caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4alg' size='340' side='right'caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALG FirstGlance]. <br>

OCA at 06:00, 5 August 2016

2016-08-05T06:00:50Z

← Older revision		Revision as of 06:00, 5 August 2016
Line 1:		Line 1:

	==N-Terminal Bromodomain of Human BRD2 With IBET-151==		==N-Terminal Bromodomain of Human BRD2 With IBET-151==
	<StructureSection load='4alg' size='340' side='right' caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4alg' size='340' side='right' caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [http://www.ebi.ac.uk/pdbsum/4alg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [http://pdbe.org/4alg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [http://www.ebi.ac.uk/pdbsum/4alg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4alg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4alg" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bouillot, A]]		[[Category: Bouillot, A]]
	[[Category: Chung, C]]		[[Category: Chung, C]]

OCA at 23:38, 24 December 2014

2014-12-24T23:38:59Z

← Older revision		Revision as of 23:38, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [http://www.ebi.ac.uk/pdbsum/4alg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [http://www.ebi.ac.uk/pdbsum/4alg PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:38, 9 December 2014

2014-12-09T15:38:34Z

← Older revision		Revision as of 15:38, 9 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~4alg~~.~~jpg~~\|~~left~~\|~~200px~~]]		==N-Terminal Bromodomain of Human BRD2 With IBET-151==
			<StructureSection load='4alg' size='340' side='right' caption='[[4alg]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4alg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALG FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GH:7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE'>1GH</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4akn\|4akn]], [[4alh\|4alh]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4alg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4alg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4alg RCSB], [http://www.ebi.ac.uk/pdbsum/4alg PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed. Crystallography is used to illustrate binding modes and rationalize their SAR. One member, I-BET151 (GSK1210151A), shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.

	~~{{STRUCTURE_4alg\| PDB=4alg \| SCENE= }}~~		Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).,Seal J, Lamotte Y, Donche F, Bouillot A, Mirguet O, Gellibert F, Nicodeme E, Krysa G, Kirilovsky J, Beinke S, McCleary S, Rioja I, Bamborough P, Chung CW, Gordon L, Lewis T, Walker AL, Cutler L, Lugo D, Wilson DM, Witherington J, Lee K, Prinjha RK Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. Epub 2012 Feb 24. PMID:22437115<ref>PMID:22437115</ref>

	~~===N-Terminal Bromodomain~~ of ~~Human BRD2 With IBET-151===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22437115}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4alg]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ALG OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022437115<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bouillot, A.]]		[[Category: Bouillot, A]]
	[[Category: Chung, C.]]		[[Category: Chung, C]]
	[[Category: Donche, F.]]		[[Category: Donche, F]]
	[[Category: Lamotte, Y.]]		[[Category: Lamotte, Y]]
	[[Category: Mirguet, O.]]		[[Category: Mirguet, O]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 07:38, 4 July 2012

2012-07-04T07:38:54Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4alg.jpg|left|200px]]
-The entry 4alg is ON HOLD
+{{STRUCTURE_4alg|  PDB=4alg  |  SCENE=  }}
-Authors: Chung, C., Lamotte, Y., Donche, F., Bouillot, A., Mirguet, O.
+===N-Terminal Bromodomain of Human BRD2 With IBET-151===
-Description: N-Terminal Bromodomain of Human BRD2 With IBET-151
+{{ABSTRACT_PUBMED_22437115}}

OCA: Protected "4alg" [edit=sysop:move=sysop]

2012-03-14T06:07:55Z

Protected "4alg" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:07, 14 March 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4alg is ON HOLD Authors: Chung, C., Lamotte, Y., Donche, F., Bouillot, A., Mirguet, O. Description: N-Terminal Bromodomain of Human BRD2 With IBET-...

2012-03-14T06:07:54Z

New page: '''Unreleased structure''' The entry 4alg is ON HOLD Authors: Chung, C., Lamotte, Y., Donche, F., Bouillot, A., Mirguet, O. Description: N-Terminal Bromodomain of Human BRD2 With IBET-...

New page

'''Unreleased structure'''

The entry 4alg is ON HOLD

Authors: Chung, C., Lamotte, Y., Donche, F., Bouillot, A., Mirguet, O.

Description: N-Terminal Bromodomain of Human BRD2 With IBET-151