4ap1 - Revision history

OCA at 11:32, 20 December 2023

2023-12-20T11:32:11Z

← Older revision		Revision as of 11:32, 20 December 2023
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	<StructureSection load='4ap1' size='340' side='right'caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4ap1' size='340' side='right'caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [https://pdbe.org/4ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [https://pdbe.org/4ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap1 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/O50641_RHORH O50641_RHORH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacterium mycoides roseum grotenfelt 1889]]~~
	~~[[Category: Ketosteroid monooxygenase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Beek, H L.van~~]]		[[Category: Rhodococcus rhodochrous]]
	[[Category: Fraaije~~, M W~~]]		[[Category: Fraaije MW]]
	[[Category: Franceschini, S]]		[[Category: Franceschini S]]
	[[Category: Martinoli, C]]		[[Category: Martinoli C]]
	[[Category: Mattevi, A]]		[[Category: Mattevi A]]
	[[Category: Pennetta, A]]		[[Category: Pennetta A]]
	[[Category: ~~Baeyer-villiger]]~~		[[Category: Van Beek HL]]
	~~[[Category: Flavin]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 05:41, 25 August 2022

2022-08-25T05:41:27Z

← Older revision		Revision as of 05:41, 25 August 2022
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	<StructureSection load='4ap1' size='340' side='right'caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4ap1' size='340' side='right'caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [~~http~~://pdbe.org/4ap1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ap1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [https://pdbe.org/4ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Monooxygenase\|Monooxygenase]]		*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bacterium mycoides roseum grotenfelt 1889]]		[[Category: Bacterium mycoides roseum grotenfelt 1889]]
	[[Category: Ketosteroid monooxygenase]]		[[Category: Ketosteroid monooxygenase]]
			[[Category: Large Structures]]
	[[Category: Beek, H L.van]]		[[Category: Beek, H L.van]]
	[[Category: Fraaije, M W]]		[[Category: Fraaije, M W]]

OCA at 09:25, 6 March 2019

2019-03-06T09:25:34Z

← Older revision		Revision as of 09:25, 6 March 2019
Line 1:		Line 1:

	==Oxidized steroid monooxygenase bound to NADP==		==Oxidized steroid monooxygenase bound to NADP==
	<StructureSection load='4ap1' size='340' side='right' caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4ap1' size='340' side='right'caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 4ap1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ap1" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Monooxygenase\|Monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bacterium mycoides roseum grotenfelt 1889]]		[[Category: Bacterium mycoides roseum grotenfelt 1889]]
	[[Category: Ketosteroid monooxygenase]]		[[Category: Ketosteroid monooxygenase]]
	[[Category: Beek, H L.~~Van~~]]		[[Category: Beek, H L.van]]
	[[Category: Fraaije, M W]]		[[Category: Fraaije, M W]]
	[[Category: Franceschini, S]]		[[Category: Franceschini, S]]

OCA at 20:10, 11 August 2016

2016-08-11T20:10:06Z

← Older revision		Revision as of 20:10, 11 August 2016
Line 1:		Line 1:

	==Oxidized steroid monooxygenase bound to NADP==		==Oxidized steroid monooxygenase bound to NADP==
	<StructureSection load='4ap1' size='340' side='right' caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4ap1' size='340' side='right' caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodococcus_rhodochrous Rhodococcus rhodochrous~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [http://pdbe.org/4ap1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ap1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacterium mycoides roseum grotenfelt 1889]]
	[[Category: Ketosteroid monooxygenase]]		[[Category: Ketosteroid monooxygenase]]
	~~[[Category: Rhodococcus rhodochrous]]~~
	[[Category: Beek, H L.Van]]		[[Category: Beek, H L.Van]]
	[[Category: Fraaije, M W]]		[[Category: Fraaije, M W]]

OCA at 13:06, 4 January 2015

2015-01-04T13:06:57Z

← Older revision		Revision as of 13:06, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap1 PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Ketosteroid monooxygenase]]		[[Category: Ketosteroid monooxygenase]]
	[[Category: Rhodococcus rhodochrous]]		[[Category: Rhodococcus rhodochrous]]
	[[Category: Beek, H L.Van.]]		[[Category: Beek, H L.Van]]
	[[Category: Fraaije, M W.]]		[[Category: Fraaije, M W]]
	[[Category: Franceschini, S.]]		[[Category: Franceschini, S]]
	[[Category: Martinoli, C.]]		[[Category: Martinoli, C]]
	[[Category: Mattevi, A.]]		[[Category: Mattevi, A]]
	[[Category: Pennetta, A.]]		[[Category: Pennetta, A]]
	[[Category: Baeyer-villiger]]		[[Category: Baeyer-villiger]]
	[[Category: Flavin]]		[[Category: Flavin]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:10, 5 June 2014

2014-06-05T08:10:47Z

← Older revision		Revision as of 08:10, 5 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ap1~~.~~png~~\|~~left~~\|~~200px~~]]		==Oxidized steroid monooxygenase bound to NADP==
			<StructureSection load='4ap1' size='340' side='right' caption='[[4ap1]], [[Resolution\|resolution]] 2.95Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ap1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP1 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aos\|4aos]], [[4aox\|4aox]], [[4ap3\|4ap3]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketosteroid_monooxygenase Ketosteroid monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.54 1.14.13.54] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ap1 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Steroid monooxygenase (STMO) from Rhodococcus rhodochrous catalyzes the Baeyer-Villiger conversion of progesterone into progesterone acetate using FAD as prosthetic group and NADPH as reducing cofactor. The enzyme shares high sequence similarity with well-characterized Baeyer-Villiger monooxygenases, including phenylacetone monooxygenase and cyclohexanone monooxygenase. The comparative biochemical and structural analysis of STMO can be particularly insightful with regard to the understanding of the substrate-specificity properties of Baeyer-Villiger monooxygenases that are emerging as promising tools in biocatalytic applications and as targets for prodrug activation. The crystal structures of STMO in the native, NADP+-bound, and two mutant forms reveal structural details on this microbial steroid-degrading enzyme. The binding of the nicotinamide ring of NADP+ is shifted with respect to the flavin compared to that observed in other monooxygenases of the same class. This finding fully supports the idea that NADP(H) adopts various positions during the catalytic cycle to perform its multiple functions in catalysis. The active site closely resembles that of phenylacetone monooxygenase. This observation led us to discover that STMO is capable of acting also on phenylacetone, which implies an impressive level of substrate promiscuity. The investigation of six mutants that target residues on the surface of the substrate-binding site reveals that enzymatic conversions of both progesterone and phenylacetone are largely insensitive to relatively drastic amino acid changes, with some mutants even displaying enhanced activity on progesterone. These features possibly reflect the fact that these enzymes are continuously evolving to acquire new activities, depending on the emerging availabilities of new compounds in the living environment.

	~~{{STRUCTURE_4ap1\| PDB=4ap1 \| SCENE= }}~~		Exploring the structural basis of substrate preferences in Baeyer-Villiger monooxygenases: insight from steroid monooxygenase.,Franceschini S, van Beek HL, Pennetta A, Martinoli C, Fraaije MW, Mattevi A J Biol Chem. 2012 May 17. PMID:22605340<ref>PMID:22605340</ref>

	~~===Oxidized steroid monooxygenase bound to NADP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22605340}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4ap1]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4AP1 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022605340<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Ketosteroid monooxygenase]]		[[Category: Ketosteroid monooxygenase]]
	[[Category: Rhodococcus rhodochrous]]		[[Category: Rhodococcus rhodochrous]]

OCA at 07:24, 11 July 2012

2012-07-11T07:24:19Z

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	{{STRUCTURE_4ap1\| PDB=4ap1 \| SCENE= }}		{{STRUCTURE_4ap1\| PDB=4ap1 \| SCENE= }}

	===Oxidized steroid monooxygenase bound to NADP===		===Oxidized steroid monooxygenase bound to NADP===


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OCA at 05:54, 30 May 2012

2012-05-30T05:54:24Z

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-'''Unreleased structure'''
+[[Image:4ap1.jpg|left|200px]]
-The entry 4ap1 is ON HOLD  until Paper Publication
+<!--
-Authors: Franceschini, S., van Beek, H.L., Martinoli, C., Pennetta, A., Fraaije, M.W., Mattevi, A.
+===Oxidized steroid monooxygenase bound to NADP===
-Description:

OCA: Protected "4ap1" [edit=sysop:move=sysop]

2012-04-11T06:34:40Z

Protected "4ap1" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:34, 11 April 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ap1 is ON HOLD until Paper Publication Authors: Franceschini, S., van Beek, H.L., Martinoli, C., Pennetta, A., Fraaije, M.W., Mattevi, A. Descript...

2012-04-11T06:34:39Z

New page: '''Unreleased structure''' The entry 4ap1 is ON HOLD until Paper Publication Authors: Franceschini, S., van Beek, H.L., Martinoli, C., Pennetta, A., Fraaije, M.W., Mattevi, A. Descript...

New page

'''Unreleased structure'''

The entry 4ap1 is ON HOLD until Paper Publication

Authors: Franceschini, S., van Beek, H.L., Martinoli, C., Pennetta, A., Fraaije, M.W., Mattevi, A.

Description: