4aps - Revision history

OCA at 10:52, 9 May 2024

2024-05-09T10:52:50Z

← Older revision		Revision as of 10:52, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='4aps' size='340' side='right'caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4aps' size='340' side='right'caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strt2 Strt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus_LMG_18311 Streptococcus thermophilus LMG 18311]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [https://pdbe.org/4aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [https://www.ebi.ac.uk/pdbsum/4aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [https://pdbe.org/4aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [https://www.ebi.ac.uk/pdbsum/4aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aps ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q5M4H8_STRT2 Q5M4H8_STRT2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Strt2~~]]		[[Category: Streptococcus thermophilus LMG 18311]]
	[[Category: Cameron~~, A D~~]]		[[Category: Cameron AD]]
	[[Category: Drew, D]]		[[Category: Drew D]]
	[[Category: Fowler~~, P W~~]]		[[Category: Fowler PW]]
	[[Category: Iwata, S]]		[[Category: Iwata S]]
	[[Category: Kwok, J]]		[[Category: Kwok J]]
	[[Category: Newstead, S]]		[[Category: Newstead S]]
	[[Category: Solcan, N]]		[[Category: Solcan N]]
	~~[[Category: Major facilitator superfamily]]~~
	~~[[Category: Mf]]~~
	~~[[Category: Peptide transport]]~~
	~~[[Category: Transport protein]]~~
	~~[[Category: Transporter~~]]

OCA at 05:42, 25 August 2022

2022-08-25T05:42:06Z

← Older revision		Revision as of 05:42, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4aps' size='340' side='right'caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4aps' size='340' side='right'caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [~~http~~://pdbe.org/4aps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [https://pdbe.org/4aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [https://www.ebi.ac.uk/pdbsum/4aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aps ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
	*[[Symporter\|Symporter]]		*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Strt2]]		[[Category: Strt2]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]

OCA at 09:14, 6 March 2019

2019-03-06T09:14:53Z

← Older revision		Revision as of 09:14, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of a POT family peptide transporter in an inward open conformation.==		==Crystal structure of a POT family peptide transporter in an inward open conformation.==
	<StructureSection load='4aps' size='340' side='right' caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4aps' size='340' side='right'caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APS FirstGlance]. <br>

OCA at 14:36, 11 August 2016

2016-08-11T14:36:23Z

← Older revision		Revision as of 14:36, 11 August 2016
Line 1:		Line 1:

	==Crystal structure of a POT family peptide transporter in an inward open conformation.==		==Crystal structure of a POT family peptide transporter in an inward open conformation.==
	<StructureSection load='4aps' size='340' side='right' caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4aps' size='340' side='right' caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_thermophilus_lmg_18311 Streptococcus thermophilus lmg 18311~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [http://www.ebi.ac.uk/pdbsum/4aps PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [http://pdbe.org/4aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [http://www.ebi.ac.uk/pdbsum/4aps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aps ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4aps" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Symporter\|Symporter]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Streptococcus thermophilus lmg 18311~~]]		[[Category: Strt2]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Drew, D]]		[[Category: Drew, D]]

OCA at 12:55, 4 January 2015

2015-01-04T12:55:26Z

← Older revision		Revision as of 12:55, 4 January 2015
Line 1:		Line 1:
	[[~~Image~~:4aps.~~png\|left\|200px~~]]		==Crystal structure of a POT family peptide transporter in an inward open conformation.==
			<StructureSection load='4aps' size='340' side='right' caption='[[4aps]], [[Resolution\|resolution]] 3.30Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_thermophilus_lmg_18311 Streptococcus thermophilus lmg 18311]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APS FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aps RCSB], [http://www.ebi.ac.uk/pdbsum/4aps PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Short chain peptides are actively transported across membranes as an efficient route for dietary protein absorption and for maintaining cellular homeostasis. In mammals, peptide transport occurs via PepT1 and PepT2, which belong to the proton-dependent oligopeptide transporter, or POT family. The recent crystal structure of a bacterial POT transporter confirmed that they belong to the major facilitator superfamily of secondary active transporters. Despite the functional characterization of POT family members in bacteria, fungi and mammals, a detailed model for peptide recognition and transport remains unavailable. In this study, we report the 3.3-A resolution crystal structure and functional characterization of a POT family transporter from the bacterium Streptococcus thermophilus. Crystallized in an inward open conformation the structure identifies a hinge-like movement within the C-terminal half of the transporter that facilitates opening of an intracellular gate controlling access to a central peptide-binding site. Our associated functional data support a model for peptide transport that highlights the importance of salt bridge interactions in orchestrating alternating access within the POT family.

	~~{{STRUCTURE_4aps\| PDB=4aps \| SCENE= }}~~		Alternating access mechanism in the POT family of oligopeptide transporters.,Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S, Newstead S EMBO J. 2012 Jun 1. doi: 10.1038/emboj.2012.157. PMID:22659829<ref>PMID:22659829</ref>

	~~===Crystal structure~~ of ~~a POT family peptide transporter in an inward open conformation~~.~~===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22659829}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4aps]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Streptococcus_thermophilus_lmg_18311 Streptococcus thermophilus lmg 18311]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022659829<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Streptococcus thermophilus lmg 18311]]		[[Category: Streptococcus thermophilus lmg 18311]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D]]
	[[Category: Drew, D.]]		[[Category: Drew, D]]
	[[Category: Fowler, P W.]]		[[Category: Fowler, P W]]
	[[Category: Iwata, S.]]		[[Category: Iwata, S]]
	[[Category: Kwok, J.]]		[[Category: Kwok, J]]
	[[Category: Newstead, S.]]		[[Category: Newstead, S]]
	[[Category: Solcan, N.]]		[[Category: Solcan, N]]
	[[Category: Major facilitator superfamily]]		[[Category: Major facilitator superfamily]]
	[[Category: Mf]]		[[Category: Mf]]

OCA at 06:40, 31 October 2012

2012-10-31T06:40:47Z

← Older revision		Revision as of 06:40, 31 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_thermophilus~~ Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA].		[[4aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_thermophilus_lmg_18311 Streptococcus thermophilus lmg 18311]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:022659829</ref><references group="xtra"/>		<ref group="xtra">PMID:022659829</ref><references group="xtra"/>
	[[Category: Streptococcus thermophilus]]		[[Category: Streptococcus thermophilus lmg 18311]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]
	[[Category: Drew, D.]]		[[Category: Drew, D.]]

OCA at 05:36, 29 August 2012

2012-08-29T05:36:53Z

← Older revision		Revision as of 05:36, 29 August 2012
Line 1:		Line 1:
	[[Image:4aps.~~jpg~~\|left\|200px]]		[[Image:4aps.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_4aps", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_4aps\| PDB=4aps \| SCENE= }}		{{STRUCTURE_4aps\| PDB=4aps \| SCENE= }}

	===Crystal structure of a POT family peptide transporter in an inward open conformation.===		===Crystal structure of a POT family peptide transporter in an inward open conformation.===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22659829}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 22659829 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_22659829}}		{{ABSTRACT_PUBMED_22659829}}

OCA at 06:07, 13 June 2012

2012-06-13T06:07:36Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4aps.jpg|left|200px]]
-The entry 4aps is ON HOLD  until Paper Publication
+<!--
-Authors: Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.
+===Crystal structure of a POT family peptide transporter in an inward open conformation.===
-Description: Crystal structure of a POT family peptide transporter in an inward open conformation.

OCA at 18:49, 2 May 2012

2012-05-02T18:49:29Z

← Older revision		Revision as of 18:49, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4aps is ON HOLD until ~~sometime in the future~~		The entry 4aps is ON HOLD until Paper Publication

	Authors: Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.		Authors: Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.

	Description: Crystal structure of a POT family peptide transporter in an inward open conformation.		Description: Crystal structure of a POT family peptide transporter in an inward open conformation.

OCA at 08:46, 25 April 2012

2012-04-25T08:46:57Z

← Older revision		Revision as of 08:46, 25 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4aps is ON HOLD		The entry 4aps is ON HOLD until sometime in the future

	Authors: Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.		Authors: Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.

	Description: Crystal structure of a POT family peptide transporter in an inward open conformation.		Description: Crystal structure of a POT family peptide transporter in an inward open conformation.