4ask - Revision history

OCA at 11:34, 20 December 2023

2023-12-20T11:34:45Z

← Older revision		Revision as of 11:34, 20 December 2023
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	<StructureSection load='4ask' size='340' side='right'caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4ask' size='340' side='right'caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xue\|2xue]], [[2xxz\|2xxz]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [https://pdbe.org/4ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [https://www.ebi.ac.uk/pdbsum/4ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ask ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [https://pdbe.org/4ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [https://www.ebi.ac.uk/pdbsum/4ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ask ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>		[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chung, C]]		[[Category: Chung C]]
	[[Category: Liddle, J]]		[[Category: Liddle J]]
	[[Category: Mosley, J]]		[[Category: Mosley J]]
	~~[[Category: Gsk-j1]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Kdm6b]]~~
	~~[[Category: Lysine specific histone demethylase]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 05:44, 25 August 2022

2022-08-25T05:44:52Z

← Older revision		Revision as of 05:44, 25 August 2022
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	<StructureSection load='4ask' size='340' side='right'caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4ask' size='340' side='right'caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xue\|2xue]], [[2xxz\|2xxz]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [~~http~~://pdbe.org/4ask PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ask PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ask ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [https://pdbe.org/4ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [https://www.ebi.ac.uk/pdbsum/4ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ask ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>		[[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]		*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Chung, C]]		[[Category: Chung, C]]
	[[Category: Liddle, J]]		[[Category: Liddle, J]]

OCA at 09:00, 6 March 2019

2019-03-06T09:00:51Z

← Older revision		Revision as of 09:00, 6 March 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1==		==CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1==
	<StructureSection load='4ask' size='340' side='right' caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4ask' size='340' side='right'caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>

OCA at 10:03, 4 August 2016

2016-08-04T10:03:27Z

← Older revision		Revision as of 10:03, 4 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1==		==CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1==
	<StructureSection load='4ask' size='340' side='right' caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4ask' size='340' side='right' caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [http://www.ebi.ac.uk/pdbsum/4ask PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [http://pdbe.org/4ask PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [http://www.ebi.ac.uk/pdbsum/4ask PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ask ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4ask" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Chung, C]]		[[Category: Chung, C]]
	[[Category: Liddle, J]]		[[Category: Liddle, J]]

OCA at 08:41, 24 December 2014

2014-12-24T08:41:04Z

← Older revision		Revision as of 08:41, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [http://www.ebi.ac.uk/pdbsum/4ask PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [http://www.ebi.ac.uk/pdbsum/4ask PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chung, C.]]		[[Category: Chung, C]]
	[[Category: Liddle, J.]]		[[Category: Liddle, J]]
	[[Category: Mosley, J.]]		[[Category: Mosley, J]]
	[[Category: Gsk-j1]]		[[Category: Gsk-j1]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]

OCA at 09:19, 11 June 2014

2014-06-11T09:19:54Z

← Older revision		Revision as of 09:19, 11 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4ask~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1==
			<StructureSection load='4ask' size='340' side='right' caption='[[4ask]], [[Resolution\|resolution]] 1.86Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=K0I:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>K0I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xue\|2xue]], [[2xxz\|2xxz]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ask RCSB], [http://www.ebi.ac.uk/pdbsum/4ask PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The jumonji (JMJ) family of histone demethylases are Fe(2+)- and alpha-ketoglutarate-dependent oxygenases that are essential components of regulatory transcriptional chromatin complexes. These enzymes demethylate lysine residues in histones in a methylation-state and sequence-specific context. Considerable effort has been devoted to gaining a mechanistic understanding of the roles of histone lysine demethylases in eukaryotic transcription, genome integrity and epigenetic inheritance, as well as in development, physiology and disease. However, because of the absence of any selective inhibitors, the relevance of the demethylase activity of JMJ enzymes in regulating cellular responses remains poorly understood. Here we present a structure-guided small-molecule and chemoproteomics approach to elucidating the functional role of the H3K27me3-specific demethylase subfamily (KDM6 subfamily members JMJD3 and UTX). The liganded structures of human and mouse JMJD3 provide novel insight into the specificity determinants for cofactor, substrate and inhibitor recognition by the KDM6 subfamily of demethylases. We exploited these structural features to generate the first small-molecule catalytic site inhibitor that is selective for the H3K27me3-specific JMJ subfamily. We demonstrate that this inhibitor binds in a novel manner and reduces lipopolysaccharide-induced proinflammatory cytokine production by human primary macrophages, a process that depends on both JMJD3 and UTX. Our results resolve the ambiguity associated with the catalytic function of H3K27-specific JMJs in regulating disease-relevant inflammatory responses and provide encouragement for designing small-molecule inhibitors to allow selective pharmacological intervention across the JMJ family.

	~~{{STRUCTURE_4ask\| PDB=4ask \| SCENE= }}~~		A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.,Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM Nature. 2012 Jul 29. doi: 10.1038/nature11262. PMID:22842901<ref>PMID:22842901</ref>

	~~===CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22842901}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4ask]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022842901<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chung, C.]]		[[Category: Chung, C.]]

OCA at 05:06, 29 August 2012

2012-08-29T05:06:06Z

← Older revision		Revision as of 05:06, 29 August 2012
Line 1:		Line 1:
	[[Image:4ask.~~jpg~~\|left\|200px]]		[[Image:4ask.png\|left\|200px]]

	{{STRUCTURE_4ask\| PDB=4ask \| SCENE= }}		{{STRUCTURE_4ask\| PDB=4ask \| SCENE= }}
Line 5:		Line 5:
	===CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1===		===CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1===

			{{ABSTRACT_PUBMED_22842901}}

	==About this Structure==		==About this Structure==
	[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA].		[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA].

			==Reference==
			<ref group="xtra">PMID:022842901</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chung, C.]]		[[Category: Chung, C.]]

OCA at 07:17, 25 July 2012

2012-07-25T07:17:49Z

← Older revision		Revision as of 07:17, 25 July 2012
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	~~'''Unreleased structure'''~~		[[Image:4ask.jpg\|left\|200px]]

	~~The entry~~ 4ask ~~is ON HOLD~~		{{STRUCTURE_4ask\| PDB=4ask \| SCENE= }}

	~~Authors: Chung, C., Mosley, J., Liddle, J.~~		===CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1===

	~~Description~~: ~~CRYSTAL STRUCTURE OF JMJD3 WITH GSK~~-J1
			==About this Structure==
			[[4ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASK OCA].
			[[Category: Homo sapiens]]
			[[Category: Chung, C.]]
			[[Category: Liddle, J.]]
			[[Category: Mosley, J.]]
			[[Category: Gsk-j1]]
			[[Category: Inhibitor]]
			[[Category: Kdm6b]]
			[[Category: Lysine specific histone demethylase]]
			[[Category: Oxidoreductase]]

OCA: Protected "4ask" [edit=sysop:move=sysop]

2012-05-09T08:42:06Z

Protected "4ask" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:42, 9 May 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4ask is ON HOLD Authors: Chung, C., Mosley, J., Liddle, J. Description: CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1

2012-05-09T08:42:06Z

New page: '''Unreleased structure''' The entry 4ask is ON HOLD Authors: Chung, C., Mosley, J., Liddle, J. Description: CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1

New page

'''Unreleased structure'''

The entry 4ask is ON HOLD

Authors: Chung, C., Mosley, J., Liddle, J.

Description: CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1