4awk - Revision history

OCA at 11:37, 20 December 2023

2023-12-20T11:37:15Z

← Older revision		Revision as of 11:37, 20 December 2023
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	<StructureSection load='4awk' size='340' side='right'caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4awk' size='340' side='right'caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~I09a0 I09a0~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AWK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [https://pdbe.org/4awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [https://www.ebi.ac.uk/pdbsum/4awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4awk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [https://pdbe.org/4awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [https://www.ebi.ac.uk/pdbsum/4awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4awk ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/C3W5S0_I09A0 C3W5S0_I09A0]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: I09a0]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cusack, S]]		[[Category: Cusack S]]
	[[Category: Kowalinski, E]]		[[Category: Kowalinski E]]
	[[Category: Ruigrok~~, R W~~]]		[[Category: Ruigrok RW]]
	[[Category: Szolar~~, O H~~]]		[[Category: Szolar OH]]
	[[Category: Wolkerstorfer, A]]		[[Category: Wolkerstorfer A]]
	[[Category: Zubieta, C]]		[[Category: Zubieta C]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Manganese-dependent]]~~
	~~[[Category: Pd...d-e...k superfamily~~]]

OCA at 05:48, 25 August 2022

2022-08-25T05:48:51Z

← Older revision		Revision as of 05:48, 25 August 2022
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	<StructureSection load='4awk' size='340' side='right'caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4awk' size='340' side='right'caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/I09a0 I09a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/I09a0 I09a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AWK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [~~http~~://pdbe.org/4awk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4awk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4awk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [https://pdbe.org/4awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [https://www.ebi.ac.uk/pdbsum/4awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4awk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4awk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4awk" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: I09a0]]		[[Category: I09a0]]
			[[Category: Large Structures]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]
	[[Category: Kowalinski, E]]		[[Category: Kowalinski, E]]

OCA at 09:02, 6 March 2019

2019-03-06T09:02:34Z

← Older revision		Revision as of 09:02, 6 March 2019
Line 1:		Line 1:

	==Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1==		==Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1==
	<StructureSection load='4awk' size='340' side='right' caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4awk' size='340' side='right'caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I09a0 I09a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I09a0 I09a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>

OCA at 17:14, 4 August 2016

2016-08-04T17:14:24Z

← Older revision		Revision as of 17:14, 4 August 2016
Line 1:		Line 1:

	==Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1==		==Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1==
	<StructureSection load='4awk' size='340' side='right' caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4awk' size='340' side='right' caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I09a0 I09a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [http://www.ebi.ac.uk/pdbsum/4awk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [http://pdbe.org/4awk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [http://www.ebi.ac.uk/pdbsum/4awk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4awk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4awk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Influenza a virus~~]]		[[Category: I09a0]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]
	[[Category: Kowalinski, E]]		[[Category: Kowalinski, E]]

OCA at 17:26, 24 December 2014

2014-12-24T17:26:34Z

← Older revision		Revision as of 17:26, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [http://www.ebi.ac.uk/pdbsum/4awk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [http://www.ebi.ac.uk/pdbsum/4awk PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Cusack, S.]]		[[Category: Cusack, S]]
	[[Category: Kowalinski, E.]]		[[Category: Kowalinski, E]]
	[[Category: Ruigrok, R W.]]		[[Category: Ruigrok, R W]]
	[[Category: Szolar, O H.]]		[[Category: Szolar, O H]]
	[[Category: Wolkerstorfer, A.]]		[[Category: Wolkerstorfer, A]]
	[[Category: Zubieta, C.]]		[[Category: Zubieta, C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Manganese-dependent]]		[[Category: Manganese-dependent]]
	[[Category: Pd...d-e...k superfamily]]		[[Category: Pd...d-e...k superfamily]]

OCA at 09:21, 11 June 2014

2014-06-11T09:21:12Z

← Older revision		Revision as of 09:21, 11 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~4awk~~.~~jpg~~\|~~left~~\|~~200px~~]]		==Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1==
			<StructureSection load='4awk' size='340' side='right' caption='[[4awk]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4awk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AWK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CI1:(2Z)-4-[(3S)-1-(BENZYLSULFONYL)-3-(4-CHLOROBENZYL)PIPERIDIN-3-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>CI1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4avg\|4avg]], [[4avl\|4avl]], [[4avq\|4avq]], [[4awf\|4awf]], [[4awg\|4awg]], [[4awh\|4awh]], [[4awm\|4awm]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4awk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4awk RCSB], [http://www.ebi.ac.uk/pdbsum/4awk PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			It is generally recognised that novel antiviral drugs, less prone to resistance, would be a desirable alternative to current drug options in order to be able to treat potentially serious influenza infections. The viral polymerase, which performs transcription and replication of the RNA genome, is an attractive target for antiviral drugs since potent polymerase inhibitors could directly stop viral replication at an early stage. Recent structural studies on functional domains of the heterotrimeric polymerase, which comprises subunits PA, PB1 and PB2, open the way to a structure based approach to optimise inhibitors of viral replication. In particular, the unique cap-snatching mechanism of viral transcription can be inhibited by targeting either the PB2 cap-binding or PA endonuclease domains. Here we describe high resolution X-ray co-crystal structures of the 2009 pandemic H1N1 (pH1N1) PA endonuclease domain with a series of specific inhibitors, including four diketo compounds and a green tea catechin, all of which chelate the two critical manganese ions in the active site of the enzyme. Comparison of the binding mode of the different compounds and that of a mononucleotide phosphate highlights, firstly, how different substituent groups on the basic metal binding scaffold can be orientated to bind in distinct sub-pockets within the active site cavity, and secondly, the plasticity of certain structural elements of the active site cavity, which result in induced fit binding. These results will be important in optimising the design of more potent inhibitors targeting the cap-snatching endonuclease activity of influenza virus polymerase.

	~~{{STRUCTURE_4awk\| PDB=4awk \| SCENE= }}~~		Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase.,Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S PLoS Pathog. 2012 Aug;8(8):e1002831. Epub 2012 Aug 2. PMID:22876177<ref>PMID:22876177</ref>

	~~===Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22876177}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[4awk]] is a 1 chain structure with sequence from [http:/~~/~~en.wikipedia.org/wiki/Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4AWK OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:022876177<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Cusack, S.]]		[[Category: Cusack, S.]]

OCA at 05:08, 29 August 2012

2012-08-29T05:08:17Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:4awk.jpg|left|200px]]
-The entry 4awk is ON HOLD  until Paper Publication
+{{STRUCTURE_4awk|  PDB=4awk  |  SCENE=  }}
-Authors: Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H.J., Ruigrok, R.W.H., Cusack, S.
+===Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1===
-Description: Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1
+{{ABSTRACT_PUBMED_22876177}}

OCA: Protected "4awk" [edit=sysop:move=sysop]

2012-06-13T05:39:33Z

Protected "4awk" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:39, 13 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4awk is ON HOLD until Paper Publication Authors: Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H.J., Ruigrok, R.W.H., Cusack, S. Descri...

2012-06-13T05:39:32Z

New page: '''Unreleased structure''' The entry 4awk is ON HOLD until Paper Publication Authors: Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H.J., Ruigrok, R.W.H., Cusack, S. Descri...

New page

'''Unreleased structure'''

The entry 4awk is ON HOLD until Paper Publication

Authors: Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H.J., Ruigrok, R.W.H., Cusack, S.

Description: Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1