4axe - Revision history

OCA at 11:37, 20 December 2023

2023-12-20T11:37:42Z

← Older revision		Revision as of 11:37, 20 December 2023
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	<StructureSection load='4axe' size='340' side='right'caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4axe' size='340' side='right'caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AXE FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-5~~-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [https://pdbe.org/4axe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [https://www.ebi.ac.uk/pdbsum/4axe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4axe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [https://pdbe.org/4axe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [https://www.ebi.ac.uk/pdbsum/4axe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4axe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>		[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath]]~~		[[Category: Arabidopsis thaliana]]
	~~[[Category: Inositol-pentakisphosphate 2-kinase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Banos-Sanz, J I~~]]		[[Category: Gonzalez B]]
	[[Category: ~~Gonzalez, B~~]]		[[Category: I Banos-Sanz J]]
	[[Category: Sanz-Aparicio, J]]		[[Category: Sanz-Aparicio J]]
	~~[[Category: Inositide signalling]]~~
	~~[[Category: Phytic acid]]~~
	~~[[Category: Protein kinase]]~~
	~~[[Category: Transferase~~]]

OCA at 05:49, 25 August 2022

2022-08-25T05:49:35Z

← Older revision		Revision as of 05:49, 25 August 2022
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	<StructureSection load='4axe' size='340' side='right'caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4axe' size='340' side='right'caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AXE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [~~http~~://pdbe.org/4axe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4axe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4axe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [https://pdbe.org/4axe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [https://www.ebi.ac.uk/pdbsum/4axe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4axe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>		[[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
			[[Category: Large Structures]]
	[[Category: Banos-Sanz, J I]]		[[Category: Banos-Sanz, J I]]
	[[Category: Gonzalez, B]]		[[Category: Gonzalez, B]]

OCA at 09:40, 6 March 2019

2019-03-06T09:40:02Z

← Older revision		Revision as of 09:40, 6 March 2019
Line 1:		Line 1:

	==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP==		==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP==
	<StructureSection load='4axe' size='340' side='right' caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4axe' size='340' side='right'caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>

OCA at 09:06, 5 August 2016

2016-08-05T09:06:46Z

← Older revision		Revision as of 09:06, 5 August 2016
Line 1:		Line 1:

	==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP==		==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP==
	<StructureSection load='4axe' size='340' side='right' caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4axe' size='340' side='right' caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [http://www.ebi.ac.uk/pdbsum/4axe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [http://pdbe.org/4axe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [http://www.ebi.ac.uk/pdbsum/4axe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4axe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4axe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
	[[Category: Banos-Sanz, J I]]		[[Category: Banos-Sanz, J I]]

OCA at 01:02, 25 December 2014

2014-12-25T01:02:07Z

← Older revision		Revision as of 01:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [http://www.ebi.ac.uk/pdbsum/4axe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [http://www.ebi.ac.uk/pdbsum/4axe PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
	[[Category: Banos-Sanz, J I.]]		[[Category: Banos-Sanz, J I]]
	[[Category: Gonzalez, B.]]		[[Category: Gonzalez, B]]
	[[Category: Sanz-Aparicio, J.]]		[[Category: Sanz-Aparicio, J]]
	[[Category: Inositide signalling]]		[[Category: Inositide signalling]]
	[[Category: Phytic acid]]		[[Category: Phytic acid]]
	[[Category: Protein kinase]]		[[Category: Protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:53, 25 June 2014

2014-06-25T06:53:57Z

← Older revision		Revision as of 06:53, 25 June 2014
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	[[~~Image~~:~~4axe~~.~~png~~\|~~left~~\|~~200px~~]]		==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP==
			<StructureSection load='4axe' size='340' side='right' caption='[[4axe]], [[Resolution\|resolution]] 2.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AXE FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]], [[4aqk\|4aqk]], [[4axc\|4axc]], [[4axd\|4axd]], [[4axf\|4axf]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4axe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4axe RCSB], [http://www.ebi.ac.uk/pdbsum/4axe PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the synthesis of inositol 1,2,3,4,5,6-hexakisphosphate from ATP and IP(5). Inositol 1,2,3,4,5,6-hexakisphosphate is implicated in crucial processes such as mRNA export, DNA editing, and phosphorus storage in plants. We previously solved the first structure of an IP(5) 2-K, which shed light on aspects of substrate recognition. However, failure of IP(5) 2-K to crystallize in the absence of inositide prompted us to study putative conformational changes upon substrate binding. We have made mutations to residues on a region of the protein that produces a clasp over the active site. A W129A mutant allowed us to capture IP(5) 2-K in its different conformations by crystallography. Thus, the IP(5) 2-K apo-form structure displays an open conformation, whereas the nucleotide-bound form shows a half-closed conformation, in contrast to the inositide-bound form obtained previously in a closed conformation. Both nucleotide and inositide binding produce large conformational changes that can be understood as two rigid domain movements, although local changes were also observed. Changes in intrinsic fluorescence upon nucleotide and inositide binding are in agreement with the crystallographic findings. Our work suggests that the clasp might be involved in enzyme kinetics, with the N-terminal lobe being essential for inositide binding and subsequent conformational changes. We also show how IP(5) 2-K discriminates between inositol 1,3,4,5-tetrakisphosphate and 3,4,5,6-tetrakisphosphate enantiomers and that substrate preference can be manipulated by Arg(130) mutation. Altogether, these results provide a framework for rational design of specific inhibitors with potential applications as biological tools for in vivo studies, which could assist in the identification of novel roles for IP(5) 2-K in mammals.

	~~{{STRUCTURE_4axe\| PDB=4axe \| SCENE= }}~~		Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: ROLE OF N-TERMINAL LOBE AND ENANTIOMERIC SUBSTRATE PREFERENCE.,Banos-Sanz JI, Sanz-Aparicio J, Whitfield H, Hamilton C, Brearley CA, Gonzalez B J Biol Chem. 2012 Aug 24;287(35):29237-49. Epub 2012 Jun 28. PMID:22745128<ref>PMID:22745128</ref>

	~~===Inositol 1~~,~~3,4,5,6-pentakisphosphate 2-kinase in complex with ADP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22745128}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[4axe]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA].~~		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]

OCA at 05:24, 5 September 2012

2012-09-05T05:24:01Z

← Older revision		Revision as of 05:24, 5 September 2012
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	[[Image:4axe.~~jpg~~\|left\|200px]]		[[Image:4axe.png\|left\|200px]]

	{{STRUCTURE_4axe\| PDB=4axe \| SCENE= }}		{{STRUCTURE_4axe\| PDB=4axe \| SCENE= }}
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	===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP===		===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP===

			{{ABSTRACT_PUBMED_22745128}}

	==About this Structure==		==About this Structure==

OCA at 07:47, 4 July 2012

2012-07-04T07:47:05Z

← Older revision		Revision as of 07:47, 4 July 2012
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	~~'''Unreleased structure'''~~		[[Image:4axe.jpg\|left\|200px]]

	~~The entry~~ 4axe ~~is ON HOLD~~ ~~until Paper Publication~~		{{STRUCTURE_4axe\| PDB=4axe \| SCENE= }}

	~~Authors: I Banos-Sanz~~, J., ~~Sanz-Aparicio~~, J., ~~Gonzalez, B.~~		===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP===

	~~Description~~: Inositol ~~1,3,4,5,6~~-pentakisphosphate 2-kinase ~~in complex with ADP~~
			==About this Structure==
			[[4axe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXE OCA].
			[[Category: Arabidopsis thaliana]]
			[[Category: Inositol-pentakisphosphate 2-kinase]]
			[[Category: Banos-Sanz, J I.]]
			[[Category: Gonzalez, B.]]
			[[Category: Sanz-Aparicio, J.]]
			[[Category: Inositide signalling]]
			[[Category: Phytic acid]]
			[[Category: Protein kinase]]
			[[Category: Transferase]]

OCA: Protected "4axe" [edit=sysop:move=sysop]

2012-06-20T07:16:57Z

Protected "4axe" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:16, 20 June 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4axe is ON HOLD until Paper Publication Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B. Description: Inositol 1,3,4,5,6-pentakisphosphat...

2012-06-20T07:16:57Z

New page: '''Unreleased structure''' The entry 4axe is ON HOLD until Paper Publication Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B. Description: Inositol 1,3,4,5,6-pentakisphosphat...

New page

'''Unreleased structure'''

The entry 4axe is ON HOLD until Paper Publication

Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B.

Description: Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP