4b2f - Revision history

OCA at 11:41, 20 December 2023

2023-12-20T11:41:34Z

← Older revision		Revision as of 11:41, 20 December 2023
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	<StructureSection load='4b2f' size='340' side='right'caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4b2f' size='340' side='right'caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Borbu Borbu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2F FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~4axz~~\|~~4axz~~]]~~</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [https://pdbe.org/4b2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [https://www.ebi.ac.uk/pdbsum/4b2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [https://pdbe.org/4b2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [https://www.ebi.ac.uk/pdbsum/4b2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2f ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/O50962_BORBU O50962_BORBU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Borbu~~]]		[[Category: Borreliella burgdorferi B31]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brangulis, K]]		[[Category: Brangulis K]]
	[[Category: Kazaks, A]]		[[Category: Kazaks A]]
	[[Category: Petrovskis, I]]		[[Category: Petrovskis I]]
	[[Category: Tars, K]]		[[Category: Tars K]]
	~~[[Category: Membrane protein]]~~
	~~[[Category: Outer surface lipoprotein~~]]

OCA at 06:57, 31 August 2022

2022-08-31T06:57:25Z

← Older revision		Revision as of 06:57, 31 August 2022
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	<StructureSection load='4b2f' size='340' side='right'caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4b2f' size='340' side='right'caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Borbu Borbu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borbu Borbu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4axz\|4axz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4axz\|4axz]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [~~http~~://pdbe.org/4b2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [https://pdbe.org/4b2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [https://www.ebi.ac.uk/pdbsum/4b2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:29, 29 January 2020

2020-01-29T17:29:22Z

← Older revision		Revision as of 17:29, 29 January 2020
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	==N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi==		==N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi==
	<StructureSection load='4b2f' size='340' side='right' caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4b2f' size='340' side='right'caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borbu Borbu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borbu Borbu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2F FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Borbu]]		[[Category: Borbu]]
			[[Category: Large Structures]]
	[[Category: Brangulis, K]]		[[Category: Brangulis, K]]
	[[Category: Kazaks, A]]		[[Category: Kazaks, A]]

OCA at 17:38, 11 August 2016

2016-08-11T17:38:10Z

← Older revision		Revision as of 17:38, 11 August 2016
Line 1:		Line 1:

	==N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi==		==N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi==
	<StructureSection load='4b2f' size='340' side='right' caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4b2f' size='340' side='right' caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Borrelia_burgdorferi_b31 Borrelia burgdorferi b31~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borbu Borbu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4axz\|4axz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4axz\|4axz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [http://www.ebi.ac.uk/pdbsum/4b2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [http://pdbe.org/4b2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [http://www.ebi.ac.uk/pdbsum/4b2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4b2f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Borrelia burgdorferi b31~~]]		[[Category: Borbu]]
	[[Category: Brangulis, K]]		[[Category: Brangulis, K]]
	[[Category: Kazaks, A]]		[[Category: Kazaks, A]]

OCA at 14:34, 4 January 2015

2015-01-04T14:34:20Z

← Older revision		Revision as of 14:34, 4 January 2015
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	~~{{STRUCTURE_4b2f\| PDB=4b2f \| SCENE= }}~~		==N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi==
	===N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi===		<StructureSection load='4b2f' size='340' side='right' caption='[[4b2f]], [[Resolution\|resolution]] 1.88Å' scene=''>
	~~{{ABSTRACT_PUBMED_23618869}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi_b31 Borrelia burgdorferi b31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2F FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4axz\|4axz]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2f RCSB], [http://www.ebi.ac.uk/pdbsum/4b2f PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Borrelia burgdorferi, which is the causative agent of Lyme disease, is transmitted from infected Ixodes ticks to a mammalian host following a tick bite. Upon changing the host organism from an Ixodes tick to a warm-blooded mammal, the spirochete must adapt to very different conditions, which is achieved by altering the expression of several genes in response to a changing environment. Recently, considerable attention has been devoted to several outer surface proteins, including BBA73, that undergo dramatic upregulation during the transmission of B. burgdorferi from infected Ixodes ticks to mammals and that are thought to be important for the establishment and maintenance of the infection. These upregulated proteins could reveal the mechanism of pathogenesis and potentially serve as novel drug targets to prevent the transmission of the pathogenic bacteria. To promote effective treatments for Lyme disease and to gain better insight into B. burgdorferi pathogenesis, we have determined the crystal structure of the upregulated outer surface protein BBA73 at 2.0A resolution. We observed that the BBA73 protein exists as a homodimer both in the crystal and in solution. The monomers interact with their N-terminal alpha-helices and form a cleft that could potentially serve as a ligand or receptor binding site. To confirm that the protein dimerizes through the interaction of the N-terminal regions, we produced an N-terminal deletion mutant of BBA73 to disrupt dimerization, and we determined the crystal structure of the truncated BBA73 protein at 1.9A resolution. The truncated protein did not form a homodimer, and the crystal structure confirmed that the overall fold is identical to that of the native BBA73 protein. Notably, a paralogous protein CspA from B. burgdorferi with known crystal structure also forms a homodimer, albeit through an entirely different interaction between the monomers.

	~~==About this Structure==~~		Structural characterization of the Borrelia burgdorferi outer surface protein BBA73 implicates dimerization as a functional mechanism.,Brangulis K, Petrovskis I, Kazaks A, Baumanis V, Tars K Biochem Biophys Res Commun. 2013 Apr 22. pii: S0006-291X(13)00654-2. doi:, 10.1016/j.bbrc.2013.04.028. PMID:23618869<ref>PMID:23618869</ref>
	~~[[4b2f]] is~~ a ~~1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Borrelia_burgdorferi_b31 Borrelia burgdorferi b31]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4B2F OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023618869</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Borrelia burgdorferi b31]]		[[Category: Borrelia burgdorferi b31]]
	[[Category: Brangulis, K.]]		[[Category: Brangulis, K]]
	[[Category: Kazaks, A.]]		[[Category: Kazaks, A]]
	[[Category: Petrovskis, I.]]		[[Category: Petrovskis, I]]
	[[Category: Tars, K.]]		[[Category: Tars, K]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Outer surface lipoprotein]]		[[Category: Outer surface lipoprotein]]

OCA at 21:08, 19 June 2013

2013-06-19T21:08:50Z

← Older revision		Revision as of 21:08, 19 June 2013
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi_b31 Borrelia burgdorferi b31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA].		[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi_b31 Borrelia burgdorferi b31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA].

			==Reference==
			<ref group="xtra">PMID:023618869</ref><references group="xtra"/><references/>
	[[Category: Borrelia burgdorferi b31]]		[[Category: Borrelia burgdorferi b31]]
	[[Category: Brangulis, K.]]		[[Category: Brangulis, K.]]

OCA at 07:46, 8 May 2013

2013-05-08T07:46:41Z

← Older revision		Revision as of 07:46, 8 May 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4b2f\| PDB=4b2f \| SCENE= }}
			===N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi===
			{{ABSTRACT_PUBMED_23618869}}

	~~The entry~~ 4b2f is ~~ON HOLD until Paper Publication~~		==About this Structure==
			[[4b2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi_b31 Borrelia burgdorferi b31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2F OCA].
	~~Authors~~: Brangulis, K., Petrovskis, I.~~, Kazaks, A.,~~ Tars, K.		[[Category: Borrelia burgdorferi b31]]
			[[Category: Brangulis, K.]]
	~~Description~~: ~~N-terminal deletion mutant of an outer~~ surface ~~protein BBA73 from Borrelia burgdorferi~~		[[Category: Kazaks, A.]]
			[[Category: Petrovskis, I.]]
			[[Category: Tars, K.]]
			[[Category: Membrane protein]]
			[[Category: Outer surface lipoprotein]]

OCA: Protected "4b2f" [edit=sysop:move=sysop]

2012-07-25T06:39:04Z

Protected "4b2f" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:39, 25 July 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4b2f is ON HOLD until Paper Publication Authors: Brangulis, K., Petrovskis, I., Kazaks, A., Tars, K. Description: N-terminal deletion mutant of an ...

2012-07-25T06:39:03Z

New page: '''Unreleased structure''' The entry 4b2f is ON HOLD until Paper Publication Authors: Brangulis, K., Petrovskis, I., Kazaks, A., Tars, K. Description: N-terminal deletion mutant of an ...

New page

'''Unreleased structure'''

The entry 4b2f is ON HOLD until Paper Publication

Authors: Brangulis, K., Petrovskis, I., Kazaks, A., Tars, K.

Description: N-terminal deletion mutant of an outer surface protein BBA73 from Borrelia burgdorferi