4bcb - Revision history

OCA at 11:47, 20 December 2023

2023-12-20T11:47:48Z

← Older revision		Revision as of 11:47, 20 December 2023
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	<StructureSection load='4bcb' size='340' side='right'caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bcb' size='340' side='right'caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [https://pdbe.org/4bcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [https://www.ebi.ac.uk/pdbsum/4bcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [https://pdbe.org/4bcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [https://www.ebi.ac.uk/pdbsum/4bcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.		[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pig]]~~		[[Category: Sus scrofa]]
	~~[[Category: Prolyl oligopeptidase~~]]		[[Category: Augustyns K]]
	[[Category: Augustyns, K]]		[[Category: Baekelandt V]]
	[[Category: Baekelandt, V]]		[[Category: Cheng JD]]
	[[Category: Cheng~~, J D~~]]		[[Category: DeMeester I]]
	[[Category: DeMeester, I]]		[[Category: Fulop V]]
	[[Category: Fulop, V]]		[[Category: Gerard M]]
	[[Category: Gerard, M]]		[[Category: Joossens J]]
	[[Category: Joossens, J]]		[[Category: Lambeir AM]]
	[[Category: Lambeir~~, A M~~]]		[[Category: Rea D]]
	[[Category: Rea, D]]		[[Category: VanDerVeken P]]
	[[Category: VanDerVeken, P]]		[[Category: VanElzen R]]
	[[Category: VanElzen, R]]
	~~[[Category: Alpha-beta-hydrolase]]~~
	~~[[Category: Alzheimers disease]]~~
	~~[[Category: Amnesia]]~~
	~~[[Category: Beta-propeller]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Parkinsons disease~~]]

OCA at 07:07, 31 August 2022

2022-08-31T07:07:54Z

← Older revision		Revision as of 07:07, 31 August 2022
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	<StructureSection load='4bcb' size='340' side='right'caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bcb' size='340' side='right'caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [~~http~~://pdbe.org/4bcb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bcb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [https://pdbe.org/4bcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [https://www.ebi.ac.uk/pdbsum/4bcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.		[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:28, 13 March 2019

2019-03-13T13:28:04Z

← Older revision		Revision as of 13:28, 13 March 2019
Line 1:		Line 1:

	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor==
	<StructureSection load='4bcb' size='340' side='right' caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bcb' size='340' side='right'caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCB FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]

OCA at 04:33, 5 August 2016

2016-08-05T04:33:14Z

← Older revision		Revision as of 04:33, 5 August 2016
Line 1:		Line 1:

	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor==
	<StructureSection load='4bcb' size='340' side='right' caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bcb' size='340' side='right' caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [http://www.ebi.ac.uk/pdbsum/4bcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [http://pdbe.org/4bcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [http://www.ebi.ac.uk/pdbsum/4bcb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bcb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	~~[[Category: Sus scrofa]]~~
	[[Category: Augustyns, K]]		[[Category: Augustyns, K]]
	[[Category: Baekelandt, V]]		[[Category: Baekelandt, V]]

OCA at 15:50, 25 December 2014

2014-12-25T15:50:13Z

← Older revision		Revision as of 15:50, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [http://www.ebi.ac.uk/pdbsum/4bcb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [http://www.ebi.ac.uk/pdbsum/4bcb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:33, 18 December 2014

2014-12-18T08:33:32Z

← Older revision		Revision as of 08:33, 18 December 2014
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	~~{{STRUCTURE_4bcb\| PDB=4bcb \| SCENE= }}~~		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor==
	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor===		<StructureSection load='4bcb' size='340' side='right' caption='[[4bcb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	{~~{ABSTRACT_PUBMED_23121075}~~}		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4I4:(5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC+ACID+6-OXIDE'>4I4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcc\|4bcc]], [[4bcd\|4bcd]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcb RCSB], [http://www.ebi.ac.uk/pdbsum/4bcb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have investigated the effect of regiospecifically introducing substituents in the P2 part of the typical dipeptide derived basic structure of PREP inhibitors. This hitherto unexplored modification type can be used to improve target affinity, selectivity, and physicochemical parameters in drug discovery programs focusing on PREP inhibitors. Biochemical evaluation of the produced inhibitors identified several substituent types that significantly increase target affinity, thereby reducing the need for an electrophilic "warhead" functionality. Pronounced PREP specificity within the group of Clan SC proteases was generally observed. Omission of the P1 electrophilic function did not affect the overall binding mode of three representative compounds, as studied by X-ray crystallography, while the P2 substituents were demonstrated to be accommodated in a cavity of PREP that, to date, has not been probed by inhibitors. Finally, we report on results of selected inhibitors in a SH-SY5Y cellular model of synucleinopathy and demonstrate a significant antiaggregation effect on alpha-synuclein.

	~~==About this Structure==~~		P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.,Van der Veken P, Fulop V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. PMID:23121075<ref>PMID:23121075</ref>
	~~[[4bcb]] is~~ a ~~1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4BCB OCA~~].
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
			*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Augustyns, K.]]		[[Category: Augustyns, K]]
	[[Category: Baekelandt, V.]]		[[Category: Baekelandt, V]]
	[[Category: Cheng, J D.]]		[[Category: Cheng, J D]]
	[[Category: DeMeester, I.]]		[[Category: DeMeester, I]]
	[[Category: Fulop, V.]]		[[Category: Fulop, V]]
	[[Category: Gerard, M.]]		[[Category: Gerard, M]]
	[[Category: Joossens, J.]]		[[Category: Joossens, J]]
	[[Category: Lambeir, A M.]]		[[Category: Lambeir, A M]]
	[[Category: Rea, D.]]		[[Category: Rea, D]]
	[[Category: VanDerVeken, P.]]		[[Category: VanDerVeken, P]]
	[[Category: VanElzen, R.]]		[[Category: VanElzen, R]]
	[[Category: Alpha-beta-hydrolase]]		[[Category: Alpha-beta-hydrolase]]
	[[Category: Alzheimers disease]]		[[Category: Alzheimers disease]]

OCA at 10:19, 13 March 2013

2013-03-13T10:19:25Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bcb|  PDB=4bcb  |  SCENE=  }}
-The entry 4bcb is ON HOLD  until Paper Publication
+==About this Structure==
+[[4bcb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCB OCA].
-Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., DeMeester, I., Lambeir, A.M., Augustyns, K.
+[[Category: Prolyl oligopeptidase]]
+[[Category: Sus scrofa]]
-Description: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor
+[[Category: Augustyns, K.]]

OCA: Protected "4bcb" [edit=sysop:move=sysop]

2012-10-10T06:44:00Z

Protected "4bcb" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:44, 10 October 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4bcb is ON HOLD until Paper Publication Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekeland...

2012-10-10T06:43:59Z

New page: '''Unreleased structure''' The entry 4bcb is ON HOLD until Paper Publication Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekeland...

New page

'''Unreleased structure'''

The entry 4bcb is ON HOLD until Paper Publication

Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., DeMeester, I., Lambeir, A.M., Augustyns, K.

Description: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor