4bcd - Revision history

OCA at 11:47, 20 December 2023

2023-12-20T11:47:51Z

← Older revision		Revision as of 11:47, 20 December 2023
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	<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.		[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pig]]~~		[[Category: Sus scrofa]]
	~~[[Category: Prolyl oligopeptidase~~]]		[[Category: Augustyns K]]
	[[Category: Augustyns, K]]		[[Category: Baekelandt V]]
	[[Category: Baekelandt, V]]		[[Category: Cheng JD]]
	[[Category: Cheng~~, J D~~]]		[[Category: DeMeester I]]
	[[Category: DeMeester, I]]		[[Category: Fulop V]]
	[[Category: Fulop, V]]		[[Category: Gerard M]]
	[[Category: Gerard, M]]		[[Category: Joossens J]]
	[[Category: Joossens, J]]		[[Category: Lambeir AM]]
	[[Category: Lambeir~~, A M~~]]		[[Category: Rea D]]
	[[Category: Rea, D]]		[[Category: VanDerVeken P]]
	[[Category: VanDerVeken, P]]		[[Category: VanElzen R]]
	[[Category: VanElzen, R]]
	~~[[Category: Alpha-beta-hydrolase]]~~
	~~[[Category: Alzheimers disease]]~~
	~~[[Category: Amnesia]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Parkinsons disease~~]]

OCA at 07:07, 31 August 2022

2022-08-31T07:07:57Z

← Older revision		Revision as of 07:07, 31 August 2022
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	<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [~~http~~://pdbe.org/4bcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.		[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:50, 13 March 2019

2019-03-13T13:50:49Z

← Older revision		Revision as of 13:50, 13 March 2019
Line 1:		Line 1:

	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==
	<StructureSection load='4bcd' size='340' side='right' caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]

OCA at 17:57, 5 August 2016

2016-08-05T17:57:05Z

← Older revision		Revision as of 17:57, 5 August 2016
Line 1:		Line 1:

	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==
	<StructureSection load='4bcd' size='340' side='right' caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bcd' size='340' side='right' caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [http://www.ebi.ac.uk/pdbsum/4bcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [http://pdbe.org/4bcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [http://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bcd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	~~[[Category: Sus scrofa]]~~
	[[Category: Augustyns, K]]		[[Category: Augustyns, K]]
	[[Category: Baekelandt, V]]		[[Category: Baekelandt, V]]

OCA at 20:48, 25 December 2014

2014-12-25T20:48:01Z

← Older revision		Revision as of 20:48, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4bcd\| PDB=4bcd \| SCENE= }}~~		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==
	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor===		<StructureSection load='4bcd' size='340' side='right' caption='[[4bcd]], [[Resolution\|resolution]] 1.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_23121075}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4amz\|4amz]], [[4an0\|4an0]], [[4an1\|4an1]], [[4ax4\|4ax4]], [[4bcb\|4bcb]], [[4bcc\|4bcc]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [http://www.ebi.ac.uk/pdbsum/4bcd PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have investigated the effect of regiospecifically introducing substituents in the P2 part of the typical dipeptide derived basic structure of PREP inhibitors. This hitherto unexplored modification type can be used to improve target affinity, selectivity, and physicochemical parameters in drug discovery programs focusing on PREP inhibitors. Biochemical evaluation of the produced inhibitors identified several substituent types that significantly increase target affinity, thereby reducing the need for an electrophilic "warhead" functionality. Pronounced PREP specificity within the group of Clan SC proteases was generally observed. Omission of the P1 electrophilic function did not affect the overall binding mode of three representative compounds, as studied by X-ray crystallography, while the P2 substituents were demonstrated to be accommodated in a cavity of PREP that, to date, has not been probed by inhibitors. Finally, we report on results of selected inhibitors in a SH-SY5Y cellular model of synucleinopathy and demonstrate a significant antiaggregation effect on alpha-synuclein.

	~~==Function==~~		P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.,Van der Veken P, Fulop V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. PMID:23121075<ref>PMID:23121075</ref>
	~~[[http~~:/~~/www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on~~ the ~~C-terminal side~~ of ~~prolyl residues within peptides that are up to approximately 30 amino acids long~~.
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==~~About this Structure~~==		==See Also==
	[[~~4bcd~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA].~~		*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Augustyns, K.]]		[[Category: Augustyns, K]]
	[[Category: Baekelandt, V.]]		[[Category: Baekelandt, V]]
	[[Category: Cheng, J D.]]		[[Category: Cheng, J D]]
	[[Category: DeMeester, I.]]		[[Category: DeMeester, I]]
	[[Category: Fulop, V.]]		[[Category: Fulop, V]]
	[[Category: Gerard, M.]]		[[Category: Gerard, M]]
	[[Category: Joossens, J.]]		[[Category: Joossens, J]]
	[[Category: Lambeir, A M.]]		[[Category: Lambeir, A M]]
	[[Category: Rea, D.]]		[[Category: Rea, D]]
	[[Category: VanDerVeken, P.]]		[[Category: VanDerVeken, P]]
	[[Category: VanElzen, R.]]		[[Category: VanElzen, R]]
	[[Category: Alpha-beta-hydrolase]]		[[Category: Alpha-beta-hydrolase]]
	[[Category: Alzheimers disease]]		[[Category: Alzheimers disease]]

OCA at 06:35, 2 May 2013

2013-05-02T06:35:24Z

← Older revision		Revision as of 06:35, 2 May 2013
Line 2:		Line 2:
	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor===		===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor===
	{{ABSTRACT_PUBMED_23121075}}		{{ABSTRACT_PUBMED_23121075}}

			==Function==
			[[http://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

	==About this Structure==		==About this Structure==

OCA at 10:20, 13 March 2013

2013-03-13T10:20:59Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bcd|  PDB=4bcd  |  SCENE=  }}
-The entry 4bcd is ON HOLD  until Paper Publication
+==About this Structure==
+[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA].
-Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., DeMeester, I., Lambeir, A.M., Augustyns, K.
+[[Category: Prolyl oligopeptidase]]
+[[Category: Sus scrofa]]
-Description: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor
+[[Category: Augustyns, K.]]

OCA: Protected "4bcd" [edit=sysop:move=sysop]

2012-10-10T06:44:04Z

Protected "4bcd" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:44, 10 October 2012
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4bcd is ON HOLD until Paper Publication Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekeland...

2012-10-10T06:44:03Z

New page: '''Unreleased structure''' The entry 4bcd is ON HOLD until Paper Publication Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekeland...

New page

'''Unreleased structure'''

The entry 4bcd is ON HOLD until Paper Publication

Authors: VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., DeMeester, I., Lambeir, A.M., Augustyns, K.

Description: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor