4bfb - Revision history

OCA at 11:49, 20 December 2023

2023-12-20T11:49:57Z

← Older revision		Revision as of 11:49, 20 December 2023
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	<StructureSection load='4bfb' size='340' side='right'caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='4bfb' size='340' side='right'caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B3P:2~~-[~~3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO~~]-2~~-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.21Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>~~[~~https://en.wikipedia.org/wiki/Memapsin_1 Memapsin~~ 1], ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [https://pdbe.org/4bfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [https://www.ebi.ac.uk/pdbsum/4bfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [https://pdbe.org/4bfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [https://www.ebi.ac.uk/pdbsum/4bfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>		[https://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Camelus glama~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Human~~]]		[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Memapsin 1]]~~		[[Category: Banner DW]]
	[[Category: Banner~~, D W~~]]		[[Category: Benz J]]
	[[Category: Benz, J]]		[[Category: Kuglstatter A]]
	[[Category: Kuglstatter, A]]		[[Category: Ruf A]]
	[[Category: Ruf, A]]		[[Category: Stihle M]]
	[[Category: Stihle, M]]
	~~[[Category: Hydrolase-immune system complex]]~~
	~~[[Category: Nanobody~~]]

OCA at 07:11, 31 August 2022

2022-08-31T07:11:34Z

← Older revision		Revision as of 07:11, 31 August 2022
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	<StructureSection load='4bfb' size='340' side='right'caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='4bfb' size='340' side='right'caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [~~http~~://pdbe.org/4bfb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bfb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [https://pdbe.org/4bfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [https://www.ebi.ac.uk/pdbsum/4bfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>		[[https://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:18, 13 March 2019

2019-03-13T13:18:49Z

← Older revision		Revision as of 13:18, 13 March 2019
Line 1:		Line 1:

	==BACE2 XAPERONE COMPLEX==		==BACE2 XAPERONE COMPLEX==
	<StructureSection load='4bfb' size='340' side='right' caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='4bfb' size='340' side='right'caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFB FirstGlance]. <br>
Line 29:		Line 29:
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Memapsin 1]]		[[Category: Memapsin 1]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]

OCA at 13:46, 4 August 2016

2016-08-04T13:46:17Z

← Older revision		Revision as of 13:46, 4 August 2016
Line 1:		Line 1:

	==BACE2 XAPERONE COMPLEX==		==BACE2 XAPERONE COMPLEX==
	<StructureSection load='4bfb' size='340' side='right' caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='4bfb' size='340' side='right' caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Lama_glama Lama glama~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [http://www.ebi.ac.uk/pdbsum/4bfb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [http://pdbe.org/4bfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [http://www.ebi.ac.uk/pdbsum/4bfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bfb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Camelus glama]]
	[[Category: ~~Lama glama~~]]		[[Category: Human]]
	[[Category: Memapsin 1]]		[[Category: Memapsin 1]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]

OCA at 09:51, 25 December 2014

2014-12-25T09:51:26Z

← Older revision		Revision as of 09:51, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [http://www.ebi.ac.uk/pdbsum/4bfb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [http://www.ebi.ac.uk/pdbsum/4bfb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:18, 21 December 2014

2014-12-21T09:18:04Z

← Older revision		Revision as of 09:18, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4bfb~~\| ~~PDB~~=4bfb \| ~~SCENE~~= }}		==BACE2 XAPERONE COMPLEX==
	===~~BACE2 XAPERONE COMPLEX~~===		<StructureSection load='4bfb' size='340' side='right' caption='[[4bfb]], [[Resolution\|resolution]] 2.21Å' scene=''>
	~~{{ABSTRACT_PUBMED_23695257}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[3zkg\|3zkg]], [[3zki\|3zki]], [[3zkm\|3zkm]], [[3zkn\|3zkn]], [[3zkq\|3zkq]], [[3zks\|3zks]], [[3zkx\|3zkx]], [[3zl7\|3zl7]], [[3zov\|3zov]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfb RCSB], [http://www.ebi.ac.uk/pdbsum/4bfb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The aspartic protease BACE2 is responsible for the shedding of the transmembrane protein Tmem27 from the surface of pancreatic beta-cells, which leads to inactivation of the beta-cell proliferating activity of Tmem27. This role of BACE2 in the control of beta-cell maintenance suggests BACE2 as a drug target for diabetes. Inhibition of BACE2 has recently been shown to lead to improved control of glucose homeostasis and to increased insulin levels in insulin-resistant mice. BACE2 has 52% sequence identity to the well studied Alzheimer's disease target enzyme beta-secretase (BACE1). High-resolution BACE2 structures would contribute significantly to the investigation of this enzyme as either a drug target or anti-target. Surface mutagenesis, BACE2-binding antibody Fab fragments, single-domain camelid antibody VHH fragments (Xaperones) and Fyn-kinase-derived SH3 domains (Fynomers) were used as crystallization helpers to obtain the first high-resolution structures of BACE2. Eight crystal structures in six different packing environments define an ensemble of low-energy conformations available to the enzyme. Here, the different strategies used for raising and selecting BACE2 binders for cocrystallization are described and the crystallization success, crystal quality and the time and resources needed to obtain suitable crystals are compared.

	~~==Function==~~		Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.,Banner DW, Gsell B, Benz J, Bertschinger J, Burger D, Brack S, Cuppuleri S, Debulpaep M, Gast A, Grabulovski D, Hennig M, Hilpert H, Huber W, Kuglstatter A, Kusznir E, Laeremans T, Matile H, Miscenic C, Rufer AC, Schlatter D, Steyaert J, Stihle M, Thoma R, Weber M, Ruf A Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1124-37. doi:, 10.1107/S0907444913006574. Epub 2013 May 15. PMID:23695257<ref>PMID:23695257</ref>
	~~[[http://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for~~ the ~~proteolytic processing of the amyloid precursor protein (APP)~~. ~~Cleaves APP~~, ~~between residues 690 and 691~~, ~~leading to the generation and extracellular release of beta-cleaved soluble APP~~, ~~and a corresponding cell-associated~~ C-~~terminal fragment which is later released by gamma-secretase~~. ~~It has also been shown that it can cleave APP between residues 671 and 672~~.~~<ref>PMID:10591213<~~/~~ref> <ref>~~PMID:~~11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref>~~ <ref>PMID:~~16816112~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4bfb]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia~~.~~org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=4BFB OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023695257</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Beta secretase\|Beta secretase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Memapsin 1]]		[[Category: Memapsin 1]]
	[[Category: Banner, D W.]]		[[Category: Banner, D W]]
	[[Category: Benz, J.]]		[[Category: Benz, J]]
	[[Category: Kuglstatter, A.]]		[[Category: Kuglstatter, A]]
	[[Category: Ruf, A.]]		[[Category: Ruf, A]]
	[[Category: Stihle, M.]]		[[Category: Stihle, M]]
	[[Category: Hydrolase-immune system complex]]		[[Category: Hydrolase-immune system complex]]
	[[Category: Nanobody]]		[[Category: Nanobody]]

OCA at 15:36, 19 June 2013

2013-06-19T15:36:08Z

← Older revision		Revision as of 15:36, 19 June 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_4bfb\| PDB=4bfb \| SCENE= }}
			===BACE2 XAPERONE COMPLEX===
			{{ABSTRACT_PUBMED_23695257}}

	~~The entry 4bfb~~ is ~~ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>

	~~Authors~~: ~~Banner, D~~.W.~~, Kuglstatter, A~~.~~, Benz, J~~.~~, Stihle, M~~.~~, Ruf, A~~.		==About this Structure==
			[[4bfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFB OCA].

	~~Description~~: ~~BACE2 XAPERONE COMPLEX~~		==Reference==
			<ref group="xtra">PMID:023695257</ref><references group="xtra"/><references/>
			[[Category: Homo sapiens]]
			[[Category: Lama glama]]
			[[Category: Memapsin 1]]
			[[Category: Banner, D W.]]
			[[Category: Benz, J.]]
			[[Category: Kuglstatter, A.]]
			[[Category: Ruf, A.]]
			[[Category: Stihle, M.]]
			[[Category: Hydrolase-immune system complex]]
			[[Category: Nanobody]]

OCA at 00:37, 4 April 2013

2013-04-04T00:37:02Z

← Older revision		Revision as of 00:37, 4 April 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4bfb is ON HOLD		The entry 4bfb is ON HOLD until Paper Publication

	Authors: Banner, D.W., Kuglstatter, A., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle~~, M., Thoma, R., Weber~~, M., Ruf, A.		Authors: Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A.

	Description: BACE2 XAPERONE COMPLEX		Description: BACE2 XAPERONE COMPLEX

OCA: Protected "4bfb" [edit=sysop:move=sysop]

2013-03-27T08:05:32Z

Protected "4bfb" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:05, 27 March 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4bfb is ON HOLD Authors: Banner, D.W., Kuglstatter, A., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski,...

2013-03-27T08:05:31Z

New page: '''Unreleased structure''' The entry 4bfb is ON HOLD Authors: Banner, D.W., Kuglstatter, A., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski,...

New page

'''Unreleased structure'''

The entry 4bfb is ON HOLD

Authors: Banner, D.W., Kuglstatter, A., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Ruf, A.

Description: BACE2 XAPERONE COMPLEX