4bfm - Revision history

OCA at 11:50, 20 December 2023

2023-12-20T11:50:16Z

← Older revision		Revision as of 11:50, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bfm' size='340' side='right'caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4bfm' size='340' side='right'caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [https://pdbe.org/4bfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [https://www.ebi.ac.uk/pdbsum/4bfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [https://pdbe.org/4bfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [https://www.ebi.ac.uk/pdbsum/4bfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>		[https://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Cho~~, H S~~]]		[[Category: Cho HS]]
	[[Category: Cho~~, Y S~~]]		[[Category: Cho YS]]
	[[Category: Park~~, S M~~]]		[[Category: Park SM]]
	[[Category: Yoo~~, J H]]~~		[[Category: Yoo JH]]
	~~[[Category: Transferase~~]]

OCA at 07:11, 31 August 2022

2022-08-31T07:11:57Z

← Older revision		Revision as of 07:11, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bfm' size='340' side='right'caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4bfm' size='340' side='right'caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BFM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [~~http~~://pdbe.org/4bfm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bfm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [https://pdbe.org/4bfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [https://www.ebi.ac.uk/pdbsum/4bfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>		[[https://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:00, 13 March 2019

2019-03-13T14:00:32Z

← Older revision		Revision as of 14:00, 13 March 2019
Line 1:		Line 1:

	==The crystal structure of mouse PK38==		==The crystal structure of mouse PK38==
	<StructureSection load='4bfm' size='340' side='right' caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4bfm' size='340' side='right'caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFM FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cho, H S]]		[[Category: Cho, H S]]

OCA at 07:49, 5 August 2016

2016-08-05T07:49:34Z

← Older revision		Revision as of 07:49, 5 August 2016
Line 1:		Line 1:

	==The crystal structure of mouse PK38==		==The crystal structure of mouse PK38==
	<StructureSection load='4bfm' size='340' side='right' caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4bfm' size='340' side='right' caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [http://www.ebi.ac.uk/pdbsum/4bfm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [http://pdbe.org/4bfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [http://www.ebi.ac.uk/pdbsum/4bfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bfm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:26, 25 December 2014

2014-12-25T00:26:34Z

← Older revision		Revision as of 00:26, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4bfm\| PDB~~=4bfm \| ~~SCENE~~= }}		==The crystal structure of mouse PK38==
	===~~The crystal~~ structure ~~of mouse PK38~~===		<StructureSection load='4bfm' size='340' side='right' caption='[[4bfm]], [[Resolution\|resolution]] 2.35Å' scene=''>
	~~{{ABSTRACT_PUBMED_24531485}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFM FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfm RCSB], [http://www.ebi.ac.uk/pdbsum/4bfm PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>		[[http://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Murine protein serine/threonine kinase 38 (MPK38) is the murine orthologue of human maternal embryonic leucine-zipper kinase (MELK), which belongs to the SNF1/AMPK family. MELK is considered to be a promising drug target for anticancer therapy because overexpression and hyperactivation of MELK is correlated with several human cancers. Activation of MPK38 requires the extended sequence (ExS) containing the ubiquitin-associated (UBA) linker and UBA domain and phosphorylation of the activation loop. However, the activation mechanism of MPK38 is unknown. This paper reports the crystal structure of MPK38 (T167E), which mimics a phosphorylated state of the activation loop, in complex with AMP-PNP. In the MPK38 structure, the UBA linker forces an inward movement of the alphaC helix. Phosphorylation of the activation loop then induces movement of the activation loop towards the C-lobe and results in interlobar cleft closure. These processes generate a fully active state of MPK38. This structure suggests that MPK38 has a similar molecular mechanism regulating activation as in other kinases of the SNF1/AMPK family.

	~~==About this Structure==~~		The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity.,Cho YS, Yoo J, Park S, Cho HS Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):514-21. doi:, 10.1107/S1399004713027806. Epub 2014 Jan 31. PMID:24531485<ref>PMID:24531485</ref>
	~~[[4bfm]] is a 1 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=4BFM OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024531485</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
	[[Category: Cho, H S.]]		== References ==
	[[Category: Cho, Y S.]]		<references/>
	[[Category: Park, S M.]]		__TOC__
	[[Category: Yoo, J H.]]		</StructureSection>
			[[Category: Lk3 transgenic mice]]
			[[Category: Cho, H S]]
			[[Category: Cho, Y S]]
			[[Category: Park, S M]]
			[[Category: Yoo, J H]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 15:54, 3 March 2014

2014-03-03T15:54:34Z

← Older revision		Revision as of 15:54, 3 March 2014
Line 1:		Line 1:
	{{STRUCTURE_4bfm\| PDB=4bfm \| SCENE= }}		{{STRUCTURE_4bfm\| PDB=4bfm \| SCENE= }}
	===The crystal structure of mouse PK38===		===The crystal structure of mouse PK38===
			{{ABSTRACT_PUBMED_24531485}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:024531485</ref><references group="xtra"/><references/>
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]
	[[Category: Cho, Y S.]]		[[Category: Cho, Y S.]]

OCA at 05:13, 13 February 2014

2014-02-13T05:13:42Z

← Older revision		Revision as of 05:13, 13 February 2014
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4bfm\| PDB=4bfm \| SCENE= }}
			===The crystal structure of mouse PK38===

	~~The entry 4bfm is ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>

	~~Authors~~: ~~Yoo, J.H., Cho, Y.S., Park, S~~.M.~~, Cho, H~~.S.		==About this Structure==
			[[4bfm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA].

	~~Description~~: ~~The crystal structure of mouse PK38~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Cho, H S.]]
			[[Category: Cho, Y S.]]
			[[Category: Park, S M.]]
			[[Category: Yoo, J H.]]
			[[Category: Transferase]]

OCA at 07:06, 16 October 2013

2013-10-16T07:06:21Z

← Older revision		Revision as of 07:06, 16 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4bfm is ON HOLD		The entry 4bfm is ON HOLD until Paper Publication

	Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.		Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.

	Description: The crystal structure of mouse PK38		Description: The crystal structure of mouse PK38

OCA at 03:15, 20 September 2013

2013-09-20T03:15:26Z

← Older revision		Revision as of 03:15, 20 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4bfm is ON HOLD ~~until Paper Publication~~		The entry 4bfm is ON HOLD

	Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.		Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.

	Description: The crystal structure of mouse PK38		Description: The crystal structure of mouse PK38

OCA at 10:45, 19 June 2013

2013-06-19T10:45:20Z

← Older revision		Revision as of 10:45, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4bfm is ON HOLD		The entry 4bfm is ON HOLD until Paper Publication

	Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.		Authors: Yoo, J.H., Cho, Y.S., Park, S.M., Cho, H.S.

	Description: The crystal structure of mouse PK38		Description: The crystal structure of mouse PK38