4blb - Revision history

OCA at 11:01, 9 May 2024

2024-05-09T11:01:47Z

← Older revision		Revision as of 11:01, 9 May 2024
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	<StructureSection load='4blb' size='340' side='right'caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4blb' size='340' side='right'caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GLC:ALPHA~~-~~D-GLUCOSE'>GLC</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[4bl8\|4bl8]]~~, ~~[[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [https://pdbe.org/4blb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [https://www.ebi.ac.uk/pdbsum/4blb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [https://pdbe.org/4blb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [https://www.ebi.ac.uk/pdbsum/4blb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blb ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/SUFU_HUMAN SUFU_HUMAN] Defects in SUFU are a cause of medulloblastoma (MDB) [MIM:[https://omim.org/entry/155255 155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in SUFU play a role in predisposition to desmoplastic MDB. These tumors make up about 20 to 30% of medulloblastomas, have a more nodular architecture than 'classical' medulloblastoma, and may have a better prognosis.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[https://www.uniprot.org/uniprot/~~GLI1_HUMAN GLI1_HUMAN~~]~~] Acts as~~ a ~~transcriptional activator~~. May ~~regulate~~ the ~~transcription~~ of ~~specific genes during normal development~~. ~~May play a role~~ in ~~craniofacial development~~ and ~~digital development~~, ~~as well as development~~ of ~~the central nervous system and gastrointestinal tract~~. ~~Mediates SHH~~ signaling and ~~thus cell proliferation~~ and ~~differentiation~~.<ref>PMID:10806483</ref> <ref>PMID:~~11238441~~</ref>		[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SUFU_HUMAN SUFU_HUMAN] Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).<ref>PMID:10564661</ref> <ref>PMID:10559945</ref> <ref>PMID:12068298</ref> <ref>PMID:10806483</ref> <ref>PMID:22365972</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cherry~~, A L~~]]		[[Category: Cherry AL]]
	[[Category: ~~Finta, C~~]]		[[Category: De Sanctis D]]
	[[Category: ~~Jovine, L~~]]		[[Category: Finta C]]
	[[Category: ~~Karlstrom, M~~]]		[[Category: Jovine L]]
	[[Category: ~~Sanctis, D De~~]]		[[Category: Karlstrom M]]
	[[Category: Toftgard, R]]		[[Category: Toftgard R]]
	~~[[Category: Chimera]]~~
	~~[[Category: Fusion protein]]~~
	~~[[Category: Gene regulation]]~~
	~~[[Category: Hedgehog signaling]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Sugar binding protein-signaling protein complex]]~~
	~~[[Category: Transcription factor~~]]

OCA at 07:17, 31 August 2022

2022-08-31T07:17:33Z

← Older revision		Revision as of 07:17, 31 August 2022
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	<StructureSection load='4blb' size='340' side='right'caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4blb' size='340' side='right'caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MAL~~:~~MALTOSE~~'>~~MAL~~</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [~~http~~://pdbe.org/4blb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4blb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4blb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [https://pdbe.org/4blb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [https://www.ebi.ac.uk/pdbsum/4blb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[~~http~~://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN]] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref>		[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[https://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN]] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cherry, A L]]		[[Category: Cherry, A L]]

OCA at 13:40, 13 March 2019

2019-03-13T13:40:25Z

← Older revision		Revision as of 13:40, 13 March 2019
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	==Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex==		==Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex==
	<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4blb' size='340' side='right'caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cherry, A L]]		[[Category: Cherry, A L]]
	[[Category: Finta, C]]		[[Category: Finta, C]]

OCA at 13:38, 15 March 2017

2017-03-15T13:38:58Z

← Older revision		Revision as of 13:38, 15 March 2017
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	<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Cherry, A L]]		[[Category: Cherry, A L]]
	[[Category: Finta, C]]		[[Category: Finta, C]]

OCA at 19:06, 5 August 2016

2016-08-05T19:06:48Z

← Older revision		Revision as of 19:06, 5 August 2016
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	==Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex==		==Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex==
	<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [http://www.ebi.ac.uk/pdbsum/4blb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [http://pdbe.org/4blb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [http://www.ebi.ac.uk/pdbsum/4blb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4blb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4blb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:04, 25 December 2014

2014-12-25T05:04:34Z

← Older revision		Revision as of 05:04, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [http://www.ebi.ac.uk/pdbsum/4blb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [http://www.ebi.ac.uk/pdbsum/4blb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[http://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN]] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:16, 21 December 2014

2014-12-21T17:16:00Z

← Older revision		Revision as of 17:16, 21 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4blb\| PDB=4blb \| SCENE= }}~~		==Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex==
	===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===		<StructureSection load='4blb' size='340' side='right' caption='[[4blb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_24311597}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4blb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bl8\|4bl8]], [[4bl9\|4bl9]], [[4bla\|4bla]], [[4bld\|4bld]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blb RCSB], [http://www.ebi.ac.uk/pdbsum/4blb PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hedgehog signalling plays a fundamental role in the control of metazoan development, cell proliferation and differentiation, as highlighted by the fact that its deregulation is associated with the development of many human tumours. SUFU is an essential intracellular negative regulator of mammalian Hedgehog signalling and acts by binding and modulating the activity of GLI transcription factors. Despite its central importance, little is known about SUFU regulation and the nature of SUFU-GLI interaction. Here, the crystal and small-angle X-ray scattering structures of full-length human SUFU and its complex with the key SYGHL motif conserved in all GLIs are reported. It is demonstrated that GLI binding is associated with major conformational changes in SUFU, including an intrinsically disordered loop that is also crucial for pathway activation. These findings reveal the structure of the SUFU-GLI interface and suggest a mechanism for an essential regulatory step in Hedgehog signalling, offering possibilities for the development of novel pathway modulators and therapeutics.

	~~==Function==~~		Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.,Cherry AL, Finta C, Karlstrom M, Jin Q, Schwend T, Astorga-Wells J, Zubarev RA, Del Campo M, Criswell AR, de Sanctis D, Jovine L, Toftgard R Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2563-79. doi:, 10.1107/S0907444913028473. Epub 2013 Nov 19. PMID:24311597<ref>PMID:24311597</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high~~-~~affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides~~. ~~[[http~~:~~//www~~.~~uniprot.org~~/~~uniprot/GLI1_HUMAN GLI1_HUMAN]] Acts as a transcriptional activator~~. ~~May regulate the transcription of specific genes during normal development~~. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:~~10806483</ref>~~ <ref>PMID:~~11238441~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4blb]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:024311597</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Cherry, A L.]]		[[Category: Cherry, A L]]
	[[Category: Finta, C.]]		[[Category: Finta, C]]
	[[Category: Jovine, L.]]		[[Category: Jovine, L]]
	[[Category: Karlstrom, M.]]		[[Category: Karlstrom, M]]
	[[Category: Sanctis, D De.]]		[[Category: Sanctis, D De]]
	[[Category: Toftgard, R.]]		[[Category: Toftgard, R]]
	[[Category: Chimera]]		[[Category: Chimera]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]

OCA at 07:58, 18 December 2013

2013-12-18T07:58:04Z

← Older revision		Revision as of 07:58, 18 December 2013
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	{{STRUCTURE_4blb\| PDB=4blb \| SCENE= }}		{{STRUCTURE_4blb\| PDB=4blb \| SCENE= }}
	===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===		===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===
	{{~~ABSTRACT_PUBMED_16459298~~}}		{{ABSTRACT_PUBMED_24311597}}

	==Function==		==Function==
Line 10:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~016459298~~</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024311597</ref><references group="xtra"/><references/>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Cherry, A L.]]		[[Category: Cherry, A L.]]

OCA at 12:32, 11 December 2013

2013-12-11T12:32:55Z

← Older revision		Revision as of 12:32, 11 December 2013
Line 1:		Line 1:
	{{STRUCTURE_4blb\| PDB=4blb \| SCENE= }}		{{STRUCTURE_4blb\| PDB=4blb \| SCENE= }}
	===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===		===Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex===
	{{~~ABSTRACT_PUBMED_10559945~~}}		{{ABSTRACT_PUBMED_16459298}}

	~~==Disease==~~
	[[http://www.uniprot.org/uniprot/GLI3_HUMAN GLI3_HUMAN]] Postaxial polydactyly type B, unilateral;Postaxial polydactyly type A, unilateral;Pallister-Hall syndrome;Postaxial polydactyly type A, bilateral;Polysyndactyly, bilateral;Polysyndactyly, unilateral;Greig cephalopolysyndactyly syndrome;Acrocallosal syndrome;Postaxial polydactyly type B, bilateral. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

	==Function==		==Function==
	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[http://www.uniprot.org/uniprot/~~GLI3_HUMAN GLI3_HUMAN~~]] ~~Has a dual function~~ as a transcriptional activator ~~and a repressor~~ of ~~the sonic hedgehog (Shh) pathway, and plays~~ a role in ~~limb~~ development~~. The full-length GLI3 form (GLI3FL) after phosphorylation~~ and ~~nuclear translocation~~, ~~acts~~ as ~~an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts~~ as ~~a repressor. A proper balance between~~ the ~~GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number~~ and ~~identity~~. ~~In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells~~ and ~~in activating chondrocyte~~ proliferation~~. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'~~.<ref>PMID:~~10693759~~</ref> <ref>PMID:11238441~~</ref> <ref>PMID:17764085~~</ref>		[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[http://www.uniprot.org/uniprot/GLI1_HUMAN GLI1_HUMAN]] Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.<ref>PMID:10806483</ref> <ref>PMID:11238441</ref>

	==About this Structure==		==About this Structure==
	[[4blb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA].		[[4blb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~010559945~~</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:016459298</ref><references group="xtra"/><references/>
			[[Category: Human]]
	[[Category: Cherry, A L.]]		[[Category: Cherry, A L.]]
	[[Category: Finta, C.]]		[[Category: Finta, C.]]

OCA at 10:25, 27 November 2013

2013-11-27T10:25:01Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4blb|  PDB=4blb  |  SCENE=  }}
-The entry 4blb is ON HOLD  until Paper Publication
+==Disease==
-Authors: Cherry, A.L., Finta, C., Karlstrom, M., De Sanctis, D., Toftgard, R., Jovine, L.
+==Function==
-Description: Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex
+==About this Structure==