4bpc - Revision history

OCA at 11:56, 20 December 2023

2023-12-20T11:56:16Z

← Older revision		Revision as of 11:56, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=CSO:S~~-~~HYDROXYCYSTEINE'>CSO</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [https://pdbe.org/4bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [https://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [https://pdbe.org/4bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [https://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.		[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Protein-tyrosine-phosphatase]]~~		[[Category: Chien PN]]
	[[Category: Chien~~, P N~~]]		[[Category: Chun HJ]]
	[[Category: Chun~~, H J~~]]		[[Category: Jeon TJ]]
	[[Category: Jeon~~, T J~~]]		[[Category: Ryu SE]]
	[[Category: Ryu~~, S E]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Proteoglycan]]~~
	~~[[Category: Redox regulation~~]]

OCA at 07:21, 31 August 2022

2022-08-31T07:21:01Z

← Older revision		Revision as of 07:21, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [~~http~~://pdbe.org/4bpc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [https://pdbe.org/4bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [https://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.		[[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:15, 4 November 2020

2020-11-04T08:15:20Z

← Older revision		Revision as of 08:15, 4 November 2020
Line 1:		Line 1:

	==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==		==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==
	<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://pdbe.org/4bpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://pdbe.org/4bpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Chien, P N]]		[[Category: Chien, P N]]

OCA at 09:07, 30 January 2019

2019-01-30T09:07:12Z

← Older revision		Revision as of 09:07, 30 January 2019
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:01, 16 November 2017

2017-11-16T16:01:21Z

← Older revision		Revision as of 16:01, 16 November 2017
Line 1:		Line 1:

	==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==		==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==
	<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://pdbe.org/4bpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://pdbe.org/4bpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:18, 30 September 2015

2015-09-30T06:18:19Z

← Older revision		Revision as of 06:18, 30 September 2015
Line 2:		Line 2:
	<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://pdbe.org/4bpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Chien, P N]]		[[Category: Chien, P N]]

OCA at 20:29, 25 December 2014

2014-12-25T20:29:39Z

← Older revision		Revision as of 20:29, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4bpc\| PDB=4bpc \| SCENE= }}~~		==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==
	===Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form===		<StructureSection load='4bpc' size='340' side='right' caption='[[4bpc]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~{{ABSTRACT_PUBMED_23820885}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [http://www.ebi.ac.uk/pdbsum/4bpc PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Protein tyrosine phosphatase sigma (PTPsigma) plays a vital role in neural development. The extracellular domain of PTPsigma binds to various proteoglycans, which control the activity of 2 intracellular PTP domains (D1 and D2). To understand the regulatory mechanism of PTPsigma, we carried out structural and biochemical analyses of PTPsigma D1D2. In the crystal structure analysis of a mutant form of D1D2 of PTPsigma, we unexpectedly found that the catalytic cysteine of D1 is oxidized to cysteine sulfenic acid, while that of D2 remained in its reduced form, suggesting that D1 is more sensitive to oxidation than D2. This finding contrasts previous observations on PTPalpha. The cysteine sulfenic acid of D1 was further confirmed by immunoblot and mass spectrometric analyses. The stabilization of the cysteine sulfenic acid in the active site of PTP suggests that the formation of cysteine sulfenic acid may function as a stable intermediate during the redox-regulation of PTPs.

	~~==Function==~~		Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form.,Jeon TJ, Chien PN, Chun HJ, Ryu SE Mol Cells. 2013 May 30. PMID:23820885<ref>PMID:23820885</ref>
	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4bpc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023820885</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Chien, P N.]]		[[Category: Chien, P N]]
	[[Category: Chun, H J.]]		[[Category: Chun, H J]]
	[[Category: Jeon, T J.]]		[[Category: Jeon, T J]]
	[[Category: Ryu, S E.]]		[[Category: Ryu, S E]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Proteoglycan]]		[[Category: Proteoglycan]]
	[[Category: Redox regulation]]		[[Category: Redox regulation]]

OCA at 04:55, 18 July 2013

2013-07-18T04:55:13Z

← Older revision		Revision as of 04:55, 18 July 2013
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4bpc\| PDB=4bpc \| SCENE= }}
			===Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form===
			{{ABSTRACT_PUBMED_23820885}}

	~~The entry 4bpc is ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.

	~~Authors~~: ~~Jeon, T~~.J.~~, Chien, P~~.~~N., Chun, H~~.J.~~, Ryu, S~~.E.		==About this Structure==
			[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA].

	~~Description~~: ~~Structure of the Catalytic Domain of~~ Protein ~~Tyrosine Phosphatase Sigma in the Sulfenic Acid Form~~		==Reference==
			<ref group="xtra">PMID:023820885</ref><references group="xtra"/><references/>
			[[Category: Homo sapiens]]
			[[Category: Protein-tyrosine-phosphatase]]
			[[Category: Chien, P N.]]
			[[Category: Chun, H J.]]
			[[Category: Jeon, T J.]]
			[[Category: Ryu, S E.]]
			[[Category: Hydrolase]]
			[[Category: Proteoglycan]]
			[[Category: Redox regulation]]

OCA: Protected "4bpc" [edit=sysop:move=sysop]

2013-06-19T10:52:08Z

Protected "4bpc" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:52, 19 June 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4bpc is ON HOLD until Paper Publication Authors: Jeon, T.J., Chien, P.N., Chun, H.J., Ryu, S.E. Description: Structure of the Catalytic Domain of P...

2013-06-19T10:52:07Z

New page: '''Unreleased structure''' The entry 4bpc is ON HOLD until Paper Publication Authors: Jeon, T.J., Chien, P.N., Chun, H.J., Ryu, S.E. Description: Structure of the Catalytic Domain of P...

New page

'''Unreleased structure'''

The entry 4bpc is ON HOLD until Paper Publication

Authors: Jeon, T.J., Chien, P.N., Chun, H.J., Ryu, S.E.

Description: Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form