4bpi - Revision history

OCA at 07:06, 27 September 2023

2023-09-27T07:06:18Z

← Older revision		Revision as of 07:06, 27 September 2023
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	<StructureSection load='4bpi' size='340' side='right'caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4bpi' size='340' side='right'caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPI FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.982Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene~~></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bpj\|4bpj]], [[4bpk\|4bpk]]</div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [https://pdbe.org/4bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [https://www.ebi.ac.uk/pdbsum/4bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [https://pdbe.org/4bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [https://www.ebi.ac.uk/pdbsum/4bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.		[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Checco, J W~~]]		[[Category: Mus musculus]]
	[[Category: ~~Fairlie, W D~~]]		[[Category: Checco JW]]
	[[Category: ~~Gellman, S H~~]]		[[Category: Fairlie WD]]
	[[Category: ~~Lee, E F~~]]		[[Category: Gellman SH]]
	[[Category: ~~Smith, B J~~]]		[[Category: Lee EF]]
	[[Category: ~~Apoptosis]]~~		[[Category: Smith BJ]]
	~~[[Category: Bim]]~~
	~~[[Category: Chimera~~]]

OCA at 07:21, 31 August 2022

2022-08-31T07:21:11Z

← Older revision		Revision as of 07:21, 31 August 2022
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	<StructureSection load='4bpi' size='340' side='right'caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4bpi' size='340' side='right'caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bpj\|4bpj]], [[4bpk\|4bpk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bpj\|4bpj]], [[4bpk\|4bpk]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [~~http~~://pdbe.org/4bpi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bpi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [https://pdbe.org/4bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [https://www.ebi.ac.uk/pdbsum/4bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.		[[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:26, 24 April 2019

2019-04-24T07:26:04Z

← Older revision		Revision as of 07:26, 24 April 2019
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	==See Also==		==See Also==
	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]		*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:13, 13 March 2019

2019-03-13T13:13:50Z

← Older revision		Revision as of 13:13, 13 March 2019
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	==Mcl-1 bound to alpha beta Puma BH3 peptide 2==		==Mcl-1 bound to alpha beta Puma BH3 peptide 2==
	<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4bpi' size='340' side='right'caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 4bpi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bpi" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Checco, J W]]		[[Category: Checco, J W]]
	[[Category: Fairlie, W D]]		[[Category: Fairlie, W D]]

OCA at 13:22, 15 March 2017

2017-03-15T13:22:00Z

← Older revision		Revision as of 13:22, 15 March 2017
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	<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Checco, J W]]		[[Category: Checco, J W]]
	[[Category: Fairlie, W D]]		[[Category: Fairlie, W D]]

OCA at 23:01, 4 August 2016

2016-08-04T23:01:25Z

← Older revision		Revision as of 23:01, 4 August 2016
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	==Mcl-1 bound to alpha beta Puma BH3 peptide 2==		==Mcl-1 bound to alpha beta Puma BH3 peptide 2==
	<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bpj\|4bpj]], [[4bpk\|4bpk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bpj\|4bpj]], [[4bpk\|4bpk]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [http://www.ebi.ac.uk/pdbsum/4bpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [http://pdbe.org/4bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [http://www.ebi.ac.uk/pdbsum/4bpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4bpi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:28, 24 December 2014

2014-12-24T20:28:30Z

← Older revision		Revision as of 20:28, 24 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4bpi\| PDB=4bpi \| SCENE= }}~~		==Mcl-1 bound to alpha beta Puma BH3 peptide 2==
	===Mcl-1 bound to alpha beta Puma BH3 peptide 2===		<StructureSection load='4bpi' size='340' side='right' caption='[[4bpi]], [[Resolution\|resolution]] 1.98Å' scene=''>
	~~{{ABSTRACT_PUBMED_23929624}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BPI FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3Q:(3S)-3,6-DIAMINO-6-OXOHEXANOIC+ACID'>B3Q</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bpj\|4bpj]], [[4bpk\|4bpk]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bpi RCSB], [http://www.ebi.ac.uk/pdbsum/4bpi PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.		[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have used computational methods to improve the affinity of a foldamer ligand for its target protein. The effort began with a previously reported alpha/beta-peptide based on the BH3 domain of the proapoptotic protein Puma; this foldamer binds tightly to Bcl-x(L) but weakly to Mcl-1. The crystal structure of the Puma-derived alpha/beta-peptide complexed to Bcl-x(L) was used as the basis for computational design of variants intended to display improved binding to Mcl-1. Molecular modelling suggested modification of three alpha residues of the original alpha/beta backbone. Individually, each substitution caused only a modest (4- to 15-fold) gain in affinity; however, together the three substitutions led to a 250-fold increase in binding to Mcl-1. These modifications had very little effect on affinity for Bcl-x(L). Crystal structures of a number of the new alpha/beta-peptides bound to either Mcl-1 or Bcl-x(L) validated the selection of each substitution. Overall, our findings demonstrate that structure-guided rational design can be used to improve affinity and alter partner selectivity of peptidic ligands with unnatural backbones that bind to specific protein partners.

	~~==About this~~ Structure==		Structure-guided rational design of alpha/beta-peptide foldamers with high affinity for BCL-2 family prosurvival proteins.,Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie WD Chembiochem. 2013 Sep 2;14(13):1564-72. doi: 10.1002/cbic.201300351. Epub 2013, Aug 8. PMID:23929624<ref>PMID:23929624</ref>
	~~[[4bpi]] is a~~ 2 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=4BPI OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:023929624</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
	[[Category: Checco, J W.]]		== References ==
	[[Category: Fairlie, W D.]]		<references/>
	[[Category: Gellman, S H.]]		__TOC__
	[[Category: Lee, E F.]]		</StructureSection>
	[[Category: Smith, B J.]]		[[Category: Human]]
			[[Category: Checco, J W]]
			[[Category: Fairlie, W D]]
			[[Category: Gellman, S H]]
			[[Category: Lee, E F]]
			[[Category: Smith, B J]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bim]]		[[Category: Bim]]
	[[Category: Chimera]]		[[Category: Chimera]]

OCA at 06:25, 9 April 2014

2014-04-09T06:25:46Z

← Older revision		Revision as of 06:25, 9 April 2014
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4bpi\| PDB=4bpi \| SCENE= }}
			===Mcl-1 bound to alpha beta Puma BH3 peptide 2===
			{{ABSTRACT_PUBMED_23929624}}

	~~The entry 4bpi is ON HOLD until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.

	~~Authors~~: ~~Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S~~.H.~~, Fairlie, W~~.D.		==About this Structure==
			[[4bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPI OCA].

	~~Description~~: ~~Mcl-1 bound to alpha beta Puma BH3 peptide 2~~		==Reference==
			<ref group="xtra">PMID:023929624</ref><references group="xtra"/><references/>
			[[Category: Checco, J W.]]
			[[Category: Fairlie, W D.]]
			[[Category: Gellman, S H.]]
			[[Category: Lee, E F.]]
			[[Category: Smith, B J.]]
			[[Category: Apoptosis]]
			[[Category: Bim]]
			[[Category: Chimera]]

OCA at 08:27, 30 June 2013

2013-06-30T08:27:18Z

← Older revision		Revision as of 08:27, 30 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 4bpi is ON HOLD		The entry 4bpi is ON HOLD until Paper Publication

	Authors: Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.		Authors: Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.

	Description: Mcl-1 bound to alpha beta Puma BH3 peptide 2		Description: Mcl-1 bound to alpha beta Puma BH3 peptide 2

OCA: Protected "4bpi" [edit=sysop:move=sysop]

2013-06-19T10:52:29Z

Protected "4bpi" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:52, 19 June 2013
(No difference)