4c2e - Revision history

OCA at 12:02, 20 December 2023

2023-12-20T12:02:15Z

← Older revision		Revision as of 12:02, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [https://pdbe.org/4c2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [https://www.ebi.ac.uk/pdbsum/4c2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2e ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [https://pdbe.org/4c2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [https://www.ebi.ac.uk/pdbsum/4c2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>		[https://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Spore formation in Bacillus subtilis relies on a regulated intramembrane proteolysis (RIP) pathway that synchronizes mother-cell and forespore development. To address the molecular basis of this SpoIV transmembrane signaling, we carried out a structure-function analysis of the activating protease CtpB. Crystal structures reflecting distinct functional states show that CtpB constitutes a ring-like protein scaffold penetrated by two narrow tunnels. Access to the proteolytic sites sequestered within these tunnels is controlled by PDZ domains that rearrange upon substrate binding. Accordingly, CtpB resembles a minimal version of a self-compartmentalizing protease regulated by a unique allosteric mechanism. Moreover, biochemical analysis of the PDZ-gated channel combined with sporulation assays reveal that activation of the SpoIV RIP pathway is induced by the concerted activity of CtpB and a second signaling protease, SpoIVB. This proteolytic mechanism is of broad relevance for cell-cell communication, illustrating how distinct signaling pathways can be integrated into a single RIP module.

			CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis.,Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021<ref>PMID:24243021</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4c2e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:21, 7 September 2022

2022-09-07T17:21:55Z

← Older revision		Revision as of 17:21, 7 September 2022
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	<StructureSection load='4c2e' size='340' side='right'caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4c2e' size='340' side='right'caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2E FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c2c\|4c2c]], [[4c2d\|4c2d]], [[4c2f\|4c2f]], [[4c2g\|4c2g]], [[4c2h\|4c2h]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [https://pdbe.org/4c2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [https://www.ebi.ac.uk/pdbsum/4c2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2e ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/C-terminal_processing_peptidase C-terminal processing peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.102 3.4.21.102] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [~~http~~://pdbe.org/4c2e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c2e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>		[[https://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Spore formation in Bacillus subtilis relies on a regulated intramembrane proteolysis (RIP) pathway that synchronizes mother-cell and forespore development. To address the molecular basis of this SpoIV transmembrane signaling, we carried out a structure-function analysis of the activating protease CtpB. Crystal structures reflecting distinct functional states show that CtpB constitutes a ring-like protein scaffold penetrated by two narrow tunnels. Access to the proteolytic sites sequestered within these tunnels is controlled by PDZ domains that rearrange upon substrate binding. Accordingly, CtpB resembles a minimal version of a self-compartmentalizing protease regulated by a unique allosteric mechanism. Moreover, biochemical analysis of the PDZ-gated channel combined with sporulation assays reveal that activation of the SpoIV RIP pathway is induced by the concerted activity of CtpB and a second signaling protease, SpoIVB. This proteolytic mechanism is of broad relevance for cell-cell communication, illustrating how distinct signaling pathways can be integrated into a single RIP module.

	CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis.,Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021<ref>PMID:24243021</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4c2e" style="background-color:#fffaf0;"></div~~>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacsu]]~~		[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	~~[[Category: C-terminal processing peptidase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Clausen, T]]		[[Category: Clausen T]]
	[[Category: Heuck, A]]		[[Category: Heuck A]]
	[[Category: Kurzbauer, R]]		[[Category: Kurzbauer R]]
	[[Category: Mastny, M]]		[[Category: Mastny M]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Proteolytic tunnel~~]]

OCA at 12:55, 13 March 2019

2019-03-13T12:55:49Z

← Older revision		Revision as of 12:55, 13 March 2019
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	==Crystal structure of the protease CtpB(S309A) present in a resting state==		==Crystal structure of the protease CtpB(S309A) present in a resting state==
	<StructureSection load='4c2e' size='340' side='right' caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4c2e' size='340' side='right'caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2E FirstGlance]. <br>
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	[[Category: Bacsu]]		[[Category: Bacsu]]
	[[Category: C-terminal processing peptidase]]		[[Category: C-terminal processing peptidase]]
			[[Category: Large Structures]]
	[[Category: Clausen, T]]		[[Category: Clausen, T]]
	[[Category: Heuck, A]]		[[Category: Heuck, A]]

OCA at 20:03, 4 August 2016

2016-08-04T20:03:10Z

← Older revision		Revision as of 20:03, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the protease CtpB(S309A) present in a resting state==		==Crystal structure of the protease CtpB(S309A) present in a resting state==
	<StructureSection load='4c2e' size='340' side='right' caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4c2e' size='340' side='right' caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c2c\|4c2c]], [[4c2d\|4c2d]], [[4c2f\|4c2f]], [[4c2g\|4c2g]], [[4c2h\|4c2h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c2c\|4c2c]], [[4c2d\|4c2d]], [[4c2f\|4c2f]], [[4c2g\|4c2g]], [[4c2h\|4c2h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/C-terminal_processing_peptidase C-terminal processing peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.102 3.4.21.102] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/C-terminal_processing_peptidase C-terminal processing peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.102 3.4.21.102] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [http://www.ebi.ac.uk/pdbsum/4c2e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [http://pdbe.org/4c2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [http://www.ebi.ac.uk/pdbsum/4c2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4c2e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:06, 24 December 2014

2014-12-24T19:06:33Z

← Older revision		Revision as of 19:06, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [http://www.ebi.ac.uk/pdbsum/4c2e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [http://www.ebi.ac.uk/pdbsum/4c2e PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:41, 21 December 2014

2014-12-21T17:41:08Z

← Older revision		Revision as of 17:41, 21 December 2014
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	~~{{STRUCTURE_4c2e\| PDB=4c2e \| SCENE= }}~~		==Crystal structure of the protease CtpB(S309A) present in a resting state==
	===Crystal structure of the protease CtpB(S309A) present in a resting state===		<StructureSection load='4c2e' size='340' side='right' caption='[[4c2e]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_24243021}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4c2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2E FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c2c\|4c2c]], [[4c2d\|4c2d]], [[4c2f\|4c2f]], [[4c2g\|4c2g]], [[4c2h\|4c2h]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/C-terminal_processing_peptidase C-terminal processing peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.102 3.4.21.102] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c2e RCSB], [http://www.ebi.ac.uk/pdbsum/4c2e PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Spore formation in Bacillus subtilis relies on a regulated intramembrane proteolysis (RIP) pathway that synchronizes mother-cell and forespore development. To address the molecular basis of this SpoIV transmembrane signaling, we carried out a structure-function analysis of the activating protease CtpB. Crystal structures reflecting distinct functional states show that CtpB constitutes a ring-like protein scaffold penetrated by two narrow tunnels. Access to the proteolytic sites sequestered within these tunnels is controlled by PDZ domains that rearrange upon substrate binding. Accordingly, CtpB resembles a minimal version of a self-compartmentalizing protease regulated by a unique allosteric mechanism. Moreover, biochemical analysis of the PDZ-gated channel combined with sporulation assays reveal that activation of the SpoIV RIP pathway is induced by the concerted activity of CtpB and a second signaling protease, SpoIVB. This proteolytic mechanism is of broad relevance for cell-cell communication, illustrating how distinct signaling pathways can be integrated into a single RIP module.

	~~==Function==~~		CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis.,Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021<ref>PMID:24243021</ref>
	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother~~ cell ~~transcription factor pro-sigma-K during sporulation~~. ~~The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation~~.~~<ref>~~PMID:~~14526016</ref> <ref>PMID:16818230</ref>~~ <ref>PMID:~~17557826~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4c2e]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4C2E OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:024243021</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
			[[Category: Bacsu]]
	[[Category: C-terminal processing peptidase]]		[[Category: C-terminal processing peptidase]]
	[[Category: Clausen, T.]]		[[Category: Clausen, T]]
	[[Category: Heuck, A.]]		[[Category: Heuck, A]]
	[[Category: Kurzbauer, R.]]		[[Category: Kurzbauer, R]]
	[[Category: Mastny, M.]]		[[Category: Mastny, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Proteolytic tunnel]]		[[Category: Proteolytic tunnel]]

OCA at 07:17, 4 December 2013

2013-12-04T07:17:14Z

← Older revision		Revision as of 07:17, 4 December 2013
Line 1:		Line 1:
	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_4c2e\| PDB=4c2e \| SCENE= }}
			===Crystal structure of the protease CtpB(S309A) present in a resting state===
			{{ABSTRACT_PUBMED_24243021}}

	The ~~entry 4c2e~~ is ~~ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>

	~~Authors~~: ~~Mastny, M~~.~~, Heuck, A~~.~~, Kurzbauer, R~~.~~, Clausen, T~~.		==About this Structure==
			[[4c2e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2E OCA].

	~~Description~~: ~~Crystal structure of the protease CtpB(S309A) present in a resting state~~		==Reference==
			<ref group="xtra">PMID:024243021</ref><references group="xtra"/><references/>
			[[Category: C-terminal processing peptidase]]
			[[Category: Clausen, T.]]
			[[Category: Heuck, A.]]
			[[Category: Kurzbauer, R.]]
			[[Category: Mastny, M.]]
			[[Category: Hydrolase]]
			[[Category: Proteolytic tunnel]]

OCA: Protected "4c2e" [edit=sysop:move=sysop]

2013-08-28T06:23:18Z

Protected "4c2e" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:23, 28 August 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4c2e is ON HOLD until Paper Publication Authors: Mastny, M., Heuck, A., Kurzbauer, R., Clausen, T. Description: Crystal structure of the protease C...

2013-08-28T06:23:17Z

New page: '''Unreleased structure''' The entry 4c2e is ON HOLD until Paper Publication Authors: Mastny, M., Heuck, A., Kurzbauer, R., Clausen, T. Description: Crystal structure of the protease C...

New page

'''Unreleased structure'''

The entry 4c2e is ON HOLD until Paper Publication

Authors: Mastny, M., Heuck, A., Kurzbauer, R., Clausen, T.

Description: Crystal structure of the protease CtpB(S309A) present in a resting state