4c8f - Revision history

OCA at 11:09, 9 May 2024

2024-05-09T11:09:38Z

← Older revision		Revision as of 11:09, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [https://pdbe.org/4c8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [https://www.ebi.ac.uk/pdbsum/4c8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8f ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.69Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [https://pdbe.org/4c8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [https://www.ebi.ac.uk/pdbsum/4c8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>		[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.

			Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4c8f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:32, 7 September 2022

2022-09-07T17:32:08Z

← Older revision		Revision as of 17:32, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c8f' size='340' side='right'caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='4c8f' size='340' side='right'caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [https://pdbe.org/4c8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [https://www.ebi.ac.uk/pdbsum/4c8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8f ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [~~http~~://pdbe.org/4c8f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c8f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>		[[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.

	Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4c8f" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==
	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]		*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Jones~~, E Y~~]]		[[Category: Jones EY]]
	[[Category: Zebisch, M]]		[[Category: Zebisch M]]
	~~[[Category: Lgr4]]~~
	~~[[Category: Lgr5]]~~
	~~[[Category: Lgr6]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: R-spo]]~~
	~~[[Category: R-spondin]]~~
	~~[[Category: Receptor]]~~
	~~[[Category: Rnf43]]~~
	~~[[Category: Rspo]]~~
	~~[[Category: Rspo1]]~~
	~~[[Category: Rspo2]]~~
	~~[[Category: Rspo3]]~~
	~~[[Category: Rspo4]]~~
	~~[[Category: Signalling]]~~
	~~[[Category: Wnt~~]]

OCA at 09:19, 20 March 2019

2019-03-20T09:19:01Z

← Older revision		Revision as of 09:19, 20 March 2019
Line 1:		Line 1:

	==mouse ZNRF3 ectodomain crystal form IV==		==mouse ZNRF3 ectodomain crystal form IV==
	<StructureSection load='4c8f' size='340' side='right' caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='4c8f' size='340' side='right'caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8F FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Jones, E Y]]		[[Category: Jones, E Y]]

OCA at 20:12, 5 August 2016

2016-08-05T20:12:40Z

← Older revision		Revision as of 20:12, 5 August 2016
Line 1:		Line 1:

	==mouse ZNRF3 ectodomain crystal form IV==		==mouse ZNRF3 ectodomain crystal form IV==
	<StructureSection load='4c8f' size='340' side='right' caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='4c8f' size='340' side='right' caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [http://www.ebi.ac.uk/pdbsum/4c8f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [http://pdbe.org/4c8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [http://www.ebi.ac.uk/pdbsum/4c8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4c8f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 05:30, 25 December 2014

2014-12-25T05:30:07Z

← Older revision		Revision as of 05:30, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4c8f~~\| ~~PDB~~=4c8f \| ~~SCENE~~= }}		==mouse ZNRF3 ectodomain crystal form IV==
	===~~mouse ZNRF3 ectodomain crystal form IV=~~==		<StructureSection load='4c8f' size='340' side='right' caption='[[4c8f]], [[Resolution\|resolution]] 2.69Å' scene=''>
	~~{{ABSTRACT_PUBMED_24225776}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8F FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8f RCSB], [http://www.ebi.ac.uk/pdbsum/4c8f PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.

	~~==Function==~~		Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>
	~~[[http://www.uniprot.org~~/~~uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3~~ ubiquitin~~-protein~~ ligase ~~that acts as a negative regulator of the Wnt signaling pathway~~ by ~~mediating~~ the ~~ubiquitination and subsequent degradation of~~ Wnt ~~receptor complex components Frizzled and LRP6. Acts on both canonical and non~~-~~canonical Wnt signaling pathway~~. ~~Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway~~, ~~thereby resticting the size of the intestinal stem cell zone~~.~~<ref>~~PMID:~~22575959</ref>~~ <ref>PMID:~~22895187~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4c8f]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:024225776</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Jones, E Y.]]		[[Category: Jones, E Y]]
	[[Category: Zebisch, M.]]		[[Category: Zebisch, M]]
	[[Category: Lgr4]]		[[Category: Lgr4]]
	[[Category: Lgr5]]		[[Category: Lgr5]]

OCA at 08:56, 27 November 2013

2013-11-27T08:56:52Z

← Older revision		Revision as of 08:56, 27 November 2013
Line 1:		Line 1:
	{{STRUCTURE_4c8f\| PDB=4c8f \| SCENE= }}		{{STRUCTURE_4c8f\| PDB=4c8f \| SCENE= }}
	===mouse ZNRF3 ectodomain crystal form IV===		===mouse ZNRF3 ectodomain crystal form IV===
			{{ABSTRACT_PUBMED_24225776}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
	[[4c8f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA].		[[4c8f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8F OCA].

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
			[[Category: Lk3 transgenic mice]]
	[[Category: Jones, E Y.]]		[[Category: Jones, E Y.]]
	[[Category: Zebisch, M.]]		[[Category: Zebisch, M.]]

OCA at 13:39, 20 November 2013

2013-11-20T13:39:50Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c8f|  PDB=4c8f  |  SCENE=  }}
-The entry 4c8f is ON HOLD
+==Function==
-Authors: Zebisch, M., Jones, E.Y.
+==About this Structure==
-Description: mouse ZNRF3 ectodomain crystal form IV
+==Reference==

OCA: Protected "4c8f" [edit=sysop:move=sysop]

2013-10-10T05:27:55Z

Protected "4c8f" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:27, 10 October 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 4c8f is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: mouse ZNRF3 ectodomain crystal form IV

2013-10-10T05:27:54Z

New page: '''Unreleased structure''' The entry 4c8f is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: mouse ZNRF3 ectodomain crystal form IV

New page

'''Unreleased structure'''

The entry 4c8f is ON HOLD

Authors: Zebisch, M., Jones, E.Y.

Description: mouse ZNRF3 ectodomain crystal form IV