4cd3 - Revision history

OCA at 08:23, 23 October 2024

2024-10-23T08:23:10Z

← Older revision		Revision as of 08:23, 23 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [https://pdbe.org/4cd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4cd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cd3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [https://pdbe.org/4cd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4cd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cd3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.		[https://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In many vertebrate tissues CD39-like ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) act in concert with ecto-5'-nucleotidase (e5NT, CD73) to convert extracellular ATP to adenosine. Extracellular ATP is a cytotoxic, pro-inflammatory signalling molecule whereas its product adenosine constitutes a universal and potent immune suppressor. Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis. Here we present the first crystal structures of an NTPDase catalytic ectodomain in complex with the Reactive Blue 2 (RB2)-derived inhibitor PSB-071. In both of the two crystal forms presented the inhibitor binds as a sandwich of two molecules at the nucleoside binding site. One of the molecules is well defined in its orientation. Specific hydrogen bonds are formed between the sulfonyl group and the nucleoside binding loop. The methylphenyl side chain functionality that improved NTPDase2-specificity is sandwiched between R245 and R394, the latter of which is exclusively found in NTPDase2. The second molecule exhibits great in-plane rotational freedom and could not be modelled in a specific orientation. In addition to this structural insight into NTPDase inhibition, the observation of the putative membrane interaction loop (MIL) in two different conformations related by a 10 degrees rotation identifies the MIL as a dynamic section of NTPDases that is potentially involved in regulation of catalysis.

			Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.,Zebisch M, Baqi Y, Schafer P, Muller CE, Strater N J Struct Biol. 2014 Jan 21. pii: S1047-8477(14)00006-9. doi:, 10.1016/j.jsb.2014.01.005. PMID:24462745<ref>PMID:24462745</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]		*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:39, 7 September 2022

2022-09-07T17:39:47Z

← Older revision		Revision as of 17:39, 7 September 2022
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	<StructureSection load='4cd3' size='340' side='right'caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='4cd3' size='340' side='right'caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cd1\|4cd1]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [https://pdbe.org/4cd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4cd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cd3 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [~~http~~://pdbe.org/4cd3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cd3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cd3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.		[[https://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	In many vertebrate tissues CD39-like ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) act in concert with ecto-5'-nucleotidase (e5NT, CD73) to convert extracellular ATP to adenosine. Extracellular ATP is a cytotoxic, pro-inflammatory signalling molecule whereas its product adenosine constitutes a universal and potent immune suppressor. Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis. Here we present the first crystal structures of an NTPDase catalytic ectodomain in complex with the Reactive Blue 2 (RB2)-derived inhibitor PSB-071. In both of the two crystal forms presented the inhibitor binds as a sandwich of two molecules at the nucleoside binding site. One of the molecules is well defined in its orientation. Specific hydrogen bonds are formed between the sulfonyl group and the nucleoside binding loop. The methylphenyl side chain functionality that improved NTPDase2-specificity is sandwiched between R245 and R394, the latter of which is exclusively found in NTPDase2. The second molecule exhibits great in-plane rotational freedom and could not be modelled in a specific orientation. In addition to this structural insight into NTPDase inhibition, the observation of the putative membrane interaction loop (MIL) in two different conformations related by a 10 degrees rotation identifies the MIL as a dynamic section of NTPDases that is potentially involved in regulation of catalysis.

	Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.,Zebisch M, Baqi Y, Schafer P, Muller CE, Strater N J Struct Biol. 2014 Jan 21. pii: S1047-8477(14)00006-9. doi:, 10.1016/j.jsb.2014.01.005. PMID:24462745<ref>PMID:24462745</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]		*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Schaefer, P~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Straeter, N~~]]		[[Category: Schaefer P]]
	[[Category: ~~Zebisch, M~~]]		[[Category: Straeter N]]
	[[Category: ~~Apyrase]]~~		[[Category: Zebisch M]]
	~~[[Category: Atpase]]~~
	~~[[Category: Drug design]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Ntpdase]]~~
	~~[[Category: Purinergic signalling~~]]

OCA at 16:35, 28 August 2019

2019-08-28T16:35:25Z

← Older revision		Revision as of 16:35, 28 August 2019
Line 1:		Line 1:

	==RnNTPDase2 X4 variant in complex with PSB-071==		==RnNTPDase2 X4 variant in complex with PSB-071==
	<StructureSection load='4cd3' size='340' side='right' caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='4cd3' size='340' side='right'caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Schaefer, P]]		[[Category: Schaefer, P]]
	[[Category: Straeter, N]]		[[Category: Straeter, N]]

OCA at 14:50, 15 November 2017

2017-11-15T14:50:58Z

← Older revision		Revision as of 14:50, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:50, 5 August 2016

2016-08-05T22:50:13Z

← Older revision		Revision as of 22:50, 5 August 2016
Line 1:		Line 1:

	==RnNTPDase2 X4 variant in complex with PSB-071==		==RnNTPDase2 X4 variant in complex with PSB-071==
	<StructureSection load='4cd3' size='340' side='right' caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='4cd3' size='340' side='right' caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cd1\|4cd1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cd1\|4cd1]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/4cd3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [http://pdbe.org/4cd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/4cd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cd3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4cd3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:32, 25 December 2014

2014-12-25T06:32:36Z

← Older revision		Revision as of 06:32, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_4cd3~~\| ~~PDB~~=4cd3 \| ~~SCENE~~= }}		==RnNTPDase2 X4 variant in complex with PSB-071==
	===~~RnNTPDase2 X4 variant~~ in complex with PSB-071~~===~~		<StructureSection load='4cd3' size='340' side='right' caption='[[4cd3]], [[Resolution\|resolution]] 2.19Å' scene=''>
	~~{{ABSTRACT_PUBMED_24462745}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4cd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CD3 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8E9:1-AMINO-4-(3-METHYLPHENYL)AMINO-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-SULFONATE'>8E9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cd1\|4cd1]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cd3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cd3 RCSB], [http://www.ebi.ac.uk/pdbsum/4cd3 PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In many vertebrate tissues CD39-like ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) act in concert with ecto-5'-nucleotidase (e5NT, CD73) to convert extracellular ATP to adenosine. Extracellular ATP is a cytotoxic, pro-inflammatory signalling molecule whereas its product adenosine constitutes a universal and potent immune suppressor. Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis. Here we present the first crystal structures of an NTPDase catalytic ectodomain in complex with the Reactive Blue 2 (RB2)-derived inhibitor PSB-071. In both of the two crystal forms presented the inhibitor binds as a sandwich of two molecules at the nucleoside binding site. One of the molecules is well defined in its orientation. Specific hydrogen bonds are formed between the sulfonyl group and the nucleoside binding loop. The methylphenyl side chain functionality that improved NTPDase2-specificity is sandwiched between R245 and R394, the latter of which is exclusively found in NTPDase2. The second molecule exhibits great in-plane rotational freedom and could not be modelled in a specific orientation. In addition to this structural insight into NTPDase inhibition, the observation of the putative membrane interaction loop (MIL) in two different conformations related by a 10 degrees rotation identifies the MIL as a dynamic section of NTPDases that is potentially involved in regulation of catalysis.

	~~==Function==~~		Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.,Zebisch M, Baqi Y, Schafer P, Muller CE, Strater N J Struct Biol. 2014 Jan 21. pii: S1047-8477(14)00006-9. doi:, 10.1016/j.jsb.2014.01.005. PMID:24462745<ref>PMID:24462745</ref>
	~~[[http~~:/~~/www~~.~~uniprot~~.~~org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission~~. ~~Hydrolyzes ADP only to a marginal extent~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[4cd3]] is~~ a ~~1 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=4CD3 OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:024462745</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
	[[Category: Schaefer, P.]]		== References ==
	[[Category: Straeter, N.]]		<references/>
	[[Category: Zebisch, M.]]		__TOC__
			</StructureSection>
			[[Category: Buffalo rat]]
			[[Category: Schaefer, P]]
			[[Category: Straeter, N]]
			[[Category: Zebisch, M]]
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 05:10, 13 February 2014

2014-02-13T05:10:39Z

← Older revision		Revision as of 05:10, 13 February 2014
Line 1:		Line 1:
	~~'''Unreleased structure'''~~		{{STRUCTURE_4cd3\| PDB=4cd3 \| SCENE= }}
			===RnNTPDase2 X4 variant in complex with PSB-071===
			{{ABSTRACT_PUBMED_24462745}}

	~~The entry 4cd3 is ON HOLD~~		==Function==
			[[http://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.

	~~Authors~~: ~~Zebisch, M~~.~~, Schaefer, P~~.~~, Straeter, N~~.		==About this Structure==
			[[4cd3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CD3 OCA].

	~~Description~~: ~~RnNTPDase2 X4 variant in complex with PSB-071~~		==Reference==
			<ref group="xtra">PMID:024462745</ref><references group="xtra"/><references/>
			[[Category: Schaefer, P.]]
			[[Category: Straeter, N.]]
			[[Category: Zebisch, M.]]
			[[Category: Apyrase]]
			[[Category: Atpase]]
			[[Category: Drug design]]
			[[Category: Hydrolase]]
			[[Category: Inhibitor]]
			[[Category: Ntpdase]]
			[[Category: Purinergic signalling]]

OCA: Protected "4cd3" [edit=sysop:move=sysop]

2013-11-13T07:13:56Z

Protected "4cd3" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:13, 13 November 2013
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OCA: New page: '''Unreleased structure''' The entry 4cd3 is ON HOLD Authors: Zebisch, M., Schaefer, P., Straeter, N. Description: RnNTPDase2 X4 variant in complex with PSB-071

2013-11-13T07:13:55Z

New page: '''Unreleased structure''' The entry 4cd3 is ON HOLD Authors: Zebisch, M., Schaefer, P., Straeter, N. Description: RnNTPDase2 X4 variant in complex with PSB-071

New page

'''Unreleased structure'''

The entry 4cd3 is ON HOLD

Authors: Zebisch, M., Schaefer, P., Straeter, N.

Description: RnNTPDase2 X4 variant in complex with PSB-071