4cha - Revision history

OCA at 08:23, 23 October 2024

2024-10-23T08:23:34Z

← Older revision		Revision as of 08:23, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/4cha_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/4cha_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 05:41, 5 June 2024

2024-06-05T05:41:07Z

← Older revision		Revision as of 05:41, 5 June 2024
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	<StructureSection load='4cha' size='340' side='right'caption='[[4cha]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4cha' size='340' side='right'caption='[[4cha]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CHA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHA FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.~~1 3.~~4.21.1] </span>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.68Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [~~http~~://pdbe.org/4cha PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cha PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cha ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [https://pdbe.org/4cha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [https://www.ebi.ac.uk/pdbsum/4cha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cha ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Chymotrypsin\|Chymotrypsin]]		*[[Chymotrypsin 3D structures\|Chymotrypsin 3D structures]]
	*[[Molecular Playground/Chymotrypsin\|Molecular Playground/Chymotrypsin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	~~[[Category: Chymotrypsin]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blow~~, D M~~]]		[[Category: Blow DM]]
	[[Category: Tsukada, H]]		[[Category: Tsukada H]]

OCA at 08:57, 20 March 2019

2019-03-20T08:57:39Z

← Older revision		Revision as of 08:57, 20 March 2019
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	==STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION==		==STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION==
	<StructureSection load='4cha' size='340' side='right' caption='[[4cha]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4cha' size='340' side='right'caption='[[4cha]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHA FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [http://pdbe.org/4cha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [http://www.ebi.ac.uk/pdbsum/4cha PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [http://pdbe.org/4cha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [http://www.ebi.ac.uk/pdbsum/4cha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cha ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/4cha_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/4cha_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
			[[Category: Large Structures]]
	[[Category: Blow, D M]]		[[Category: Blow, D M]]
	[[Category: Tsukada, H]]		[[Category: Tsukada, H]]

OCA at 02:24, 9 February 2016

2016-02-09T02:24:21Z

← Older revision		Revision as of 02:24, 9 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHA FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [http://www.ebi.ac.uk/pdbsum/4cha PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [http://pdbe.org/4cha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [http://www.ebi.ac.uk/pdbsum/4cha PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4cha ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 4cha" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:23, 18 December 2014

2014-12-18T08:23:52Z

← Older revision		Revision as of 08:23, 18 December 2014
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	~~{{STRUCTURE_4cha\| PDB=4cha \| SCENE= }}~~		==STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION==
	===STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION===		<StructureSection load='4cha' size='340' side='right' caption='[[4cha]], [[Resolution\|resolution]] 1.68Å' scene=''>
	~~{{ABSTRACT_PUBMED_4046030}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHA FirstGlance]. <br>
			</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cha RCSB], [http://www.ebi.ac.uk/pdbsum/4cha PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/4cha_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Diffraction data for alpha-chymotrypsin crystals at -10 degrees C were measured at 1.68 A resolution and refined by restrained structure-factor least-squares refinement. The two independent chymotrypsin molecules in the crystallographic asymmetric unit were refined independently. The overall structure of alpha-chymotrypsin is little changed from published co-ordinates. The root-mean-square shift of C alpha co-ordinates is 0.42 A, co-ordinates for the two molecules showing a root-mean-square difference of 0.19 A. Certain regions with high disorder (residues 9 to 14, 73 to 79) remain difficult to interpret and several side-chains are disordered. Some water molecule positions have been changed. The absence of the tosyl group has made a significant difference to the refined structure at the active site. This now agrees closely with other enzymes of the trypsin family that have been refined at high resolution. There is a strong hydrogen bond between N epsilon 2 (His57) and O gamma (Ser195) in the free enzyme, in line with the published description of the charge relay system.

	~~==About this~~ Structure==		Structure of alpha-chymotrypsin refined at 1.68 A resolution.,Tsukada H, Blow DM J Mol Biol. 1985 Aug 20;184(4):703-11. PMID:4046030<ref>PMID:4046030</ref>
	~~[[4cha]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=4CHA OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Chymotrypsin\|Chymotrypsin]]		*[[Chymotrypsin\|Chymotrypsin]]
	*[[Molecular Playground/Chymotrypsin\|Molecular Playground/Chymotrypsin]]		*[[Molecular Playground/Chymotrypsin\|Molecular Playground/Chymotrypsin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:004046030<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
	[[Category: Blow, D M.]]		[[Category: Blow, D M]]
	[[Category: Tsukada, H.]]		[[Category: Tsukada, H]]

OCA at 10:18, 11 March 2013

2013-03-11T10:18:21Z

← Older revision		Revision as of 10:18, 11 March 2013
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	~~[[Image:4cha.png\|left\|200px]]~~

	{{STRUCTURE_4cha\| PDB=4cha \| SCENE= }}		{{STRUCTURE_4cha\| PDB=4cha \| SCENE= }}

	===STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION===		===STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION===

	{{ABSTRACT_PUBMED_4046030}}		{{ABSTRACT_PUBMED_4046030}}

OCA at 12:19, 20 October 2012

2012-10-20T12:19:04Z

← Older revision		Revision as of 12:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[4cha]] is a 6 chain structure ~~of [[Chymotrypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA].		[[4cha]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHA OCA].

	==See Also==		==See Also==

OCA at 08:20, 26 July 2012

2012-07-26T08:20:15Z

← Older revision		Revision as of 08:20, 26 July 2012
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	[[Image:4cha.png\|left\|200px]]		[[Image:4cha.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_4cha", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_4cha\| PDB=4cha \| SCENE= }}		{{STRUCTURE_4cha\| PDB=4cha \| SCENE= }}

	===STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION===		===STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_4046030}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 4046030 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_4046030}}		{{ABSTRACT_PUBMED_4046030}}

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	==See Also==		==See Also==
	*[[Chymotrypsin]]		*[[Chymotrypsin\|Chymotrypsin]]
	*[[Molecular ~~playground~~/Chymotrypsin]]		*[[Molecular Playground/Chymotrypsin\|Molecular Playground/Chymotrypsin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~4046030~~</ref><references group="xtra"/>		<ref group="xtra">PMID:004046030</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
	[[Category: Blow, D M.]]		[[Category: Blow, D M.]]
	[[Category: Tsukada, H.]]		[[Category: Tsukada, H.]]

OCA at 13:18, 28 December 2010

2010-12-28T13:18:07Z

← Older revision		Revision as of 13:18, 28 December 2010
Line 23:		Line 23:
	==See Also==		==See Also==
	*[[Chymotrypsin]]		*[[Chymotrypsin]]
			*[[Molecular playground/Chymotrypsin]]

	==Reference==		==Reference==

OCA: Protected "4cha" [edit=sysop:move=sysop]

2010-12-26T21:06:52Z

Protected "4cha" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:06, 26 December 2010
(No difference)